Faculty of Medicine
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Item type:Publication, Efikasnost i bezbednost terapija Elbasvir/Grazoprevir kod pacijenata sa hronicnim hepatitsom C(Udruzenje Infektologa Srbije, 2022-05); ;Toshevski, Boban; ;Magdalena Gasheva - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Alergijska bronhopulmonalna aspergiloza (ABPA) bez istorije bronhijalne astme(Udruženje bronhologa Srbije, 2022-11); ;Kochovska-Kamchevska, Nade ;Baloski, Marjan ;Bushev, JanePoposki, BozidarPlućne bolesti povezane sa aspergilusom su spektar poremećaja kao što su aspergilom, invazivna aspergiloza i alergijska bronhopulmonalna aspergiloza (ABPA). ABPA je imunološka bronhopulmonalna inflamacija (reakcija preosetljivosti disajnih puteva) zbog imunološkog odgovora donjih respiratornih puteva protiv Aspergillus fumigatus. Glavni dijagnostički kriterijumi za ABPA su 1) bronhijalna astma, 2) plućna infiltracija, 3) eozinofilija periferne krvi, 4) pozitivan kožni test na Aspergillus fumigatus, 5) precipitin u serumu na Aspergillus semulino E fumigatus (E6) globulin E6) ), i 7) centralne bronhiektazije. Dijagnozu ABPA treba razmotriti kod astmatičara svih uzrasta. Evolucija bolesti obuhvata pet faza od akutnog do fibroznog stadijuma uključujući plućnu fibrozu i respiratornu insuficijenciju. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hemoptiza kao prva klinička prezentacija metastatskog seminoma kod 24-godišnjeg pacijenta(Udruženje bronhologa Srbije, 2022-11); ;Kochovska-Kamchevska, Nade ;Baloski, Marjan ;Bushev, JanePoposki, BozhidarRak testisa je najčešći malignitet kod muškaraca od 15 do 35 godina. On čini oko 1% svih karcinoma. Prevalencija raka testisa kod belaca je 4,5 puta veća kod crnaca. Seminomi su osetljiviji na terapiju zračenjem i lakše se leče od neseminoma. To je vrsta raka koja počinje u zametnim ćelijama kod muškaraca. Seminomi se najčešće javljaju u testisu, ali se mogu javiti iu drugim delovima tela, kao što su mozak, grudni koš ili stomak. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COMPARISON OF MAXIMAL OXYGEN CONSUMPTION, RESTING METABOLIC RATE AND BODY COMPOSITION ANALYSIS BETWEEN AEROBIC AND ANAEROBIC SPORTS(ANTHROPOLOGICAL SOCIETY OF SERBIA, 2023-09-27); ; ; The aim of this study is to compare the values of maximal oxygen consumption (VO2 max), resting metabolic rate (RMR) and body composition analysis between aerobic and anaerobic sports. 90 male athletes (25,34 ±5,6 age; 179,78±6.9 height/cm; 78,66±6,9 weight/kg and 24,34±2,75 BMI/ kg/m2) were tested for this study. The athletes were divided in 2 groups, I group- aerobic sports (endurance) (n=63), II group- anaerobic sports (strength) (n=26). Height was measured with stadiometer - СЕКА, body composition by means of bioelectrical impedance analysis - InBody 720, (Great Britain), RMR with indirect calorimetry- Fit Mate, COSMED, (Italy) and VO2 max with ergometric test Bruce on treadmill (ergo _run medical_α 24). Results showed that anaerobic athletes have significantly higher values of weight (83 ± 12kg) , BMI (26 ± 3 kg/m2) and body fat percentage-PBF (15 ± 8%), compared to aerobic athletes: weight (76 ±7 kg), BMI (23±1,5 kg/m2) and PBF (12 ±3 %). Aerobic athletes have significantly higher values skeletal muscle mass percentage -SMM (50 ±2%) and VO2 max (50,1 ± 4 ml/kg/min) (p<0,05) and higher values of RMR (2265 ±276 kcal/day) compared to anaerobic athletes: % SMM (48 ± 4%), VO2 max (45,9± 5 ml/kg/min) and RMR (2258 ± 314 kcal/day).Kako bi postigli više vrednosti VO2 max i bolju performasnu sportisti kombinuju submaksimalne i maksimalne trenažne sesije. To keep high SMM, endurance athletes need to have higher calorie intake. To achieve higher VO2 max values and better performance athletes tend to have combined submaximal and maximal training sessions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY COMPOSITION AND RESPIRATORY PARAMETER ANALYSIS AT FOOTBALL PLAYERS(ANTHROPOLOGICAL SOCIETY OF SERBIA, 2023-09-27); ; ; ; Pulmonary function tests (PFTs) are commonly used for evaluating respiratory status and managing persons with known pulmonary disease. They have become part of routine health examinations in respiratory, occupational, and sports medicine, and in public-health screening. The results of PFTs are interpreted in relation to normal range reference values, as recommended by the guidelines of the American Thoracic Society (ATS) and the European Community forCoal and Steel (ECCS). Spirometry is a gold standard pulmonary function test that measureshow an individual inhales or exhales volumes of air as a function of time. It is the mostimportant and most frequently performed pulmonary function testing procedure, having becomeindispensable for the prevention, diagnosis, and evaluation of various respiratory impairments. Anumber of 61 football players were divided into 2 groups according to their age, 13 (13.85 ± 3.26) and27 years (23.82 ± 3.32). This study was organized by the Institute of Medical, Experimentaland Applied Physiology and Anthropology, Medical faculty – UKIM, Skopje. The spirometry method was performed with the Spirobank II spirometer (Rome, Italy), for the followingparameters: forced vital capacity (FVC), forced expiratory volume in the first second (FEV1),and the ratio FEV1/FVC ratio.Body composition analyzer InBody 720, Great Britain, was usedto determine body weight (kg), body height (cm), body mass index - BMI weight (kg / m 2 ),skeletal muscle mass SMM (kg) and the amount of proteins (kg) and minerals (kg). We did notfind any statistically significant differences for forced vital capacity (FVC), forced expiratoryvolume in the first second (FEV1), and the ratio FEV1/FVC ratio. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY COMPOSITION ANALYSIS IN FEMALE FITNESS COMPETITORS AND RECREATIONISTS(ANTHROPOLOGICAL SOCIETY OF SERBIA, 2023-09-27); ;Adam Gligoroski ;Zivko StojchevThe fitness became very popular sport for women globally, whether they are involved in exercise as leisure activity or for competitive reasons.Body shape and suitable body composition is a primary goal for all participants in fitness programs, recreationists and competitors. The aim of this study isto compare the body composition characteristics of female fitness and bodybuilding recreationists and competitors. This study involved 39 adult women, aged 18 to 40, who were divided into four groups: women competitors (N= 9), recreational women (N=30), Body composition was analyzed with bioelectrical impedance analysis, InBody 720. The comparison of BIA obesity parameters showed that BMI was insignificantly different between competitors and recreationists, 22.5 vs 23.03 ( p=0.659). The fitness competitors showed higher volume of body fluids (ICW and ECW), higher protein and mineral components. Body fat mass (BFM) was statistically greater in recreationists comparing the competitors 18.58 kg vs 12.47 kg. Mean values of body fat percentage were also statistically higher in recreationists in comparison with the competitors, 27.25% vs 16.39%. Fitness competitorshad a significantly higher fat-free mass, i.e. muscle component, and significantlylower fat component. Recreational exercisers had significantly higher parameters of obesity (body fat mass, BF% and WHR) than fitness contestants. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cerebral thrombosis - epidemiological characteristics and prevention(2006-03); ;Ivanoska, Aleksandra ;Ristevska, Stojna ;Mihajlovska, AnaVelkovska, Maja - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PLUCNA EMBOLIJA U BOLESNIKA S LEIDENOVOM TROMBOFILIJOM FAKTORA V I PSORIJAZOL: PRIKAZ SLUCAJ.(Association of pulmologists from Republika Srpska, 2023-05) ;Baloski Marjan; ;Bushev Jane ;Brishkoska-Boshkovski VesnaHasan TanerCilj: Genetski faktori rizika pove!avaju rizik venske tromboembolije. Poremecaji u sintezi ili aktivnosti faktora koagulacije. Faktor V Leiden, protrombin (20210-A), antitrombinski deficit, deficit proteina C i proteina S i hiperhomocisteinemija najcesce su mutacije gena povezanih sa venskim tromboembolijom . Uvod : Psorijaza i prisutvo mutacije trombofilnih gena povecava rizik venske tromboembolije. Prethodna venska tromboembolija je jedan od najjacih faktora rizika, cak i kod pacijenata koji su aktivno leceni antikoagulansom. Psorijaza je kompleksna imuno posredovana bolest, povezana sa kardiovaskularnim rizikom, markerima hiperkoagulabilnosti i povisenim homocisteinom. Mnogo izvjestaja o opservacijama sugerira povecanu ucestalost venskih trombembolickih dogadaja kod pacijenata sa psorijazom. Nalazi: Prikazujemo bolesnika s nasljednom trombofilijom i kronicnom difuznom psorijazom kompliciranom plu!nom embolijom. Analiza DNK ukazuje na prisutnost homozigoze za mutaciju faktora V Leidena. Dermatoloska anamneza je pozitivna na psorijazu. Zaklju!ak: Prikaz ovog slucaja ukazuje na povezanost venske tromboembolije i psorijaze. Pacijenti sa naslednom trombofilijom, psorijazom I plucnim tromboembolizmom, imaju visoki rizik od razvoj venske tromboembolije. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NEUROFIBROMATOSIS TYPE 1 ASSOCIATED WITH PHEOCHROMOCYTOMA-CASE REPORT(2022-10); ;Todorova, Biljana ;Stevchevska, AleksandraIntroduction: Neurofibromatosis type 1 is an autosomal dominant disease caused by a genetic mutation of the neurofibromin1 gene located on chromosomal segment 17q11.2 on the long arm of chromosome 17. It occurs in 1:4000 individuals. Besides of typical neurofibromas, it is often associated with other tumors: pheochromocytoma, astrocytoma, rhabdomyosarcoma, carcinoid of the duodenum, somatostatinoma, adenoma of the parathyroid gland. Pheochromocytoma is a neuroendocrine tumor originating from the chromaffin cells of the adrenal medulla with an incidence of 1:100,000 inhabitants per year and a prevalence of 8:1,000,000 population. Case report: A 65-year-old male patient was admitted to our hospital for examination of a right adrenal mass with dimensions of 55x55 mm seen on ultrasound. The diagnosis of neurofibromatosis is histologically confirmed before puberty. Status praesens: multiple neurofibromatous lesions of the trunk, hypertension of 210/110 mmHg, tachycardia of 125/min. An abdominal CT scan was performed with the finding of a round, hypodense mass with dimensions of 5 cm on the right adrenal gland. Left adrenal gland was normal. The laboratory showed elevated urinary catecholamines: VMA 81.9 µmol/dU(7.0-68 µmol/dU) metanephrine 10.4 µmol/dU(Do 5.5 µmol/dU), thus the diagnosis of pheochromocytoma was confirmed. A right adrenalectomy was performed. Postoperative control catecholamines: VMA: 17.3/26.4/26.6 µmol/dU; Metanephrine: 2.0/1.5/1.0 µmol/dU; Pathohistological finding: Well-defined nests of polygonal cells surrounded by fibrovascular stroma. Conclusion: Due to the genetic predisposition, in patients with NF1 the development of Tu other than neurofibromas should be considered. Screening of patients with NF1 for pheochromocytoma by determination of catecholamines in 24 h urine is recommended, as one in 48 patients with NF1 develops pheochromocytoma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ЕФИКАСНОСТ И БЕЗБЕДНОСТ НА ЕМПАГЛИФЛОЗИН И ЕДНАШ НЕДЕЛЕН СУБКУТАН СЕМАГЛУТИД КАЈ ПАЦИЕНТИ СО ДИЈАБЕТЕС ТИП 2 ВО ШТИП(2022-10) ;Велкоска Накова, Валентина ;Докузова, СтојкаЦел: Ефикасноста и безбедноста на новите лекови (еднаш неделен субкутан семаглутид (OWSem) и емпаглифлозин (Empa)) беа анализирани кај пациенти со дијабетес тип 2 (T2DM) во Клиничката болница во Штип, Р.С. Македонија. Материјал и методи: Сто дваесет и еден пациент лекувани за прв пат со OWSema или Empa беа ретроспективно анализирани. Се следеше гликемиската контрола, серумскиот креатинин, намалувањето во телесната тежина, присутните коморбидитети и евентуална хоспитализација за време на третманот. Резултати: Помеѓу 61 пациент третиран со OWSema и 60 пациенти третирани со Empa, немаше статистички значајни разлики во возраста, полот, индексот на телесна маса, времетраењето на дијабетот и бројот на пациенти третирани со инсулин. Двата лека (OWSema и Empa) постигнаа статистички значајно намалување на HbA1c по 6, 12 и 18 месеци (9,2; наспроти 7,6; 6,7; 6,6 и 9,3; наспроти 7,5; 7,2, 7,5%, соодветно) третман. Немаше разлики во вредноста на серумскиот креатинин помеѓу посетите во двете групи. Во периодот од 2 години починале 3ца пациенти (5%) со повеќе коморбидитети од групата Empa. Еден пациент од групата Empa беше хоспитализиран поради акутен пулмонален едем и двајца од групата OWSema поради TIA и акутен коронарен синдром. Просечното намалување на тежината беше поизразено во групата OWSema (6,0 наспроти 4,0 kg). Пет пациенти го прекинаа третманот со Empa на почетокот поради некомплицирана уринарна инфекција, а еден го прекина OWSema поради гастроинтестинална нетолеранција. Осум пациенти не ја толерираа дозата од 1 mg и продолжија со 0,5 mg OWSema. Заклучок. Субкутаниот семаглутид и емпаглифлозин се ефикасни и безбедни за третман на Т2ДМ.
