Faculty of Medicine
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Item type:Publication, Food preparation skills and obesity risk in European children aged 6–9 years: a cross-sectional study using WHO COSI 2022–2024’(Springer Science and Business Media LLC, 2026-02-28) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SQUAMOUS CELL CARCINOMA ARISING IN A KELOID SCAR: A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Angelovska TIntroduction: Keloids are characterized by abnormal fibroblast proliferation and excessive collagen deposition. While typically benign, they have been recognized as potential predisposing factors for cutaneous neoplasia. Case Presentation: We present a rare case of squamous cell carcinoma (SCC) arising within a keloid scar in a 38-year-old female with a history of exuberant keloid formation on the feet. Histopathological examination of the excised lesion revealed moderately differentiated SCC developing within keloid tissue, marked by invasive nests of atypical squamous cells and keratin pearl formation embedded in dense keloidal stroma. Conclusion: Although exceedingly rare, malignant transformation of keloid scars into SCC can occur, particularly in lesions exposed to chronic irritation, inflammation, ulceration, repeated trauma, or ultraviolet radiation. Clinicians should maintain a high index of suspicion when evaluating morphological changes in long-standing keloids. Early biopsy of suspicious lesions is crucial for timely diagnosis and appropriate management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ASSOCIATION BETWEEN LOW BIRTH WEIGHT AND MODE OF DELIVERY IN TERM PREGNANCY(Association of Albanian Medical Doctors in Macedonia, 2025-10) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, UMBILICAL CORD CORTISOL LEVELS IN TERM AND LATE-PRETERM NEWBORNS(Macedonian Association of Anatomists and Morphologists, 2025); ; Baevska Vuchkovikj, TatjanaCortisol, a glucocorticoid hormone secreted by the adrenal cortex, plays a pivotal role in human physiology, particularly in stress response regulation, immune function, and metabolic homeostasis. In the perinatal period, cortisol becomes a critical determinant of neonatal outcomes, as it drives the maturation of key fetal organs and facilitates the transition from intrauterine to extra uterine life. A surge in fetal cortisol levels during late gestation is integral to the development of the lungs, liver, and brain, which are essential for postnatal survival. Moreover, the umbilical cord, as the primary channel of maternal-fetal exchange, provides an invaluable window into the hormonal state of the fetus at birth. An observational prospective study analyzing umbilical cord blood cortisol levels, focusing on their associations with gestational age, was conducted at the Mother Teresa Hospital in Skopje, and 88 samples were obtained for analysis. The aim was to compare cortisol levels in healthy and appropriate for gestational age (AGA) newborns, depending on their gestational age. The results showed a mean cortisol level of 93.41 [95%CI 82.72 – 104.10]. In term infants the mean cortisol level was significantly higher, with a mean value of 100.60 [95%CI 88.940 – 112.259], than in preterm ones where mean cortisol level was 51.91 [95%CI 40.528 – 63.301], with a statistically significant difference (p<0.0012). The significant associations between cortisol levels and gestational age highlight the potential utility of umbilical cord blood cortisol as a biomarker for assessing neonatal stress and adaptation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PRIMARY SINONASAL MENINGIOMA MIMICKING BENIGN NASAL LESIONS - A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Jovcheva, AIntroduction: Primary extracranial meningiomas are rare neoplasms, accounting for less than 2% of all meningiomas. The sinonasal tract represents an uncommon site of origin and frequently presents diagnostic challenges due to nonspecific clinical and radiological features. Case Presentation: A 79-year-old male presented with a unilateral nasal cavity mass. Computed tomography revealed diffuse polypoid mucosal thickening with near-complete opacification of paranasal sinuses and obliteration of aeration. Histopathology showed a circumscribed neoplastic proliferation arranged in lobular and whorled patterns beneath intact respiratory epithelium. Tumor cells displayed uniform morphology with oval nuclei, eosinophilic cytoplasm, and inconspicuous nucleoli. Psammoma bodies and delicate vascular channels were present. Necrosis, nuclear atypia, and mitotic activity were absent. Immunohistochemistry showed strong positivity for epithelial membrane antigen (EMA), vimentin, p63, and progesterone receptor, while cytokeratin AE1/AE3, CD34, smooth muscle actin (SMA), S100, SOX10, desmin, and synaptophysin were negative. The proliferative index (Ki-67) was <5%. Discussion: Extracranial meningiomas are rare neoplasms with poorly understood histogenesis, presumably arising from displaced meningothelial cells during embryonic development. Sinonasal meningiomas may mimic other nasal masses including nasal polyps, inverted papilloma, olfactory neuroblastoma, or carcinoma. In this case, the morphological features combined with the supportive immunohistochemical profile confirmed the diagnosis of WHO Grade I meningothelial meningioma with angiomatous features. Conclusion: Primary sinonasal meningioma should be included in the differential diagnosis of sinonasal masses. Accurate recognition through comprehensive histopathological and immunohistochemical analysis is essential for proper diagnosis and management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Appendiceal neuroendocrine tumor in a pediatric patient – A case report(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2026-02); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Safety and equity in scaling minimally invasive surgery worldwide in 109 countries using cholecystectomy as a tracer procedure: a prospective cohort study(Elsevier BV, 2026-02); Background Minimally invasive surgery is rapidly expanding globally, yet there is insufficient knowledge of how to scale this technology safely and equitably across diverse health systems. We aimed to identify health-system factors associated with safe implementation of minimally invasive We conducted a multicentre, prospective cohort study of consecutive adults undergoing cholecystectomy between July 31 and Nov 19, 2023, in 1218 hospitals across 109 countries. Data were collected by more than 10 000 health-care workers using a core measurement set mapped to the WHO Health System Building Blocks and the Global Patient Safety Action Plan. The primary outcome was 30-day procedure-specific complications, with multilevel logistic regression used to examine associations between health-system features and patient outcomes. This study is registered on ClinicalTrials.gov (NCT06223061). Findings Among 52 187 included patients, the adjusted procedure-specific complication rate varied 40-fold between hospitals, from 0·3% in the lowest risk quintile to 12·1% in the highest risk quintile. Despite large structural differences across income groups in access to minimally invasive surgery, diagnostics, and emergency services, country income level was not independently associated with complication rates (adjusted odds ratio [OR] 0·81 [95% CI 0·59–1·10] for upper-middle income vs high income and 0·99 [0·70–1·39] for lower-middle income or low income vs high income). Three modifiable hospital-level factors were strongly associated with safer outcomes: establishment of local simulation-based training facilities (adjusted OR 0·78 [0·71–0·86]; p<0·0001), adoption of intraoperative safety and communication strategies (0·87 [0·79–0·96]; p=0·0046), and on-site CT diagnostics (0·79 [0·65–0·97]; p=0·0220). Training facilities showed the greatest benefit in hospitals with limited infrastructure and an inexperienced workforce: the number needed to treat to prevent a procedure-specific complication was 21 (95% CI 14–35; p<0·0001). Interpretation Safe implementation of minimally invasive surgery varies widely worldwide but is not defined by national income level; differences in outcomes reflect the ability of health systems to adopt and safely deploy new surgical techniques. We identified for the first time that the presence of local simulation-based training facilities is independently associated with improved patient outcomes. Simulation appears to be fundamental to the safe delivery of minimally invasive surgery, particularly in resource-constrained settings. Together with safety systems and diagnostic capacity, these findings offer actionable targets for health systems seeking to equitably scale up essential surgical technologies. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COMPARISON OF ENDOSCOPIC AND CONSERVATIVE MANAGEMENT IN PEDIATRIC VESICOURETERAL REFLUX: A RETROSPECTIVE STUDY(Macedonian Association of Anatomists and Morphologists, 2025-11); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Disparities in minimally invasive surgery for elective inguinal hernia repair across Europe: secondary analysis of an international cohort study(Oxford University Press (OUP), 2025-11) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LAPAROSCOPIC VERSUS OPEN KASAI PORTOENTEROSTOMY FOR BILIARY ATRESIA: A SYSTEMATIC REVIEW AND META-ANALYSIS BY THE PEDIATRIC SURGERY META-ANALYSIS STUDY GROUP (PESMA)(European Society of Paediatric Endoscopic Surgeons, 2025-10)