Faculty of Medicine

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Start date: 2023Language: search.filters.language.(Other)

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    Обзор классификаций внутрипротоковых папиллярных муцинозных неоплазий, показаний к хирургическому вмешательству и его результатов
    (VIDAR Publishing House, 2025)
    Đorđević V.
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    Markovic M.
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    Protić M.
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    Knežević Đ.
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    Basarić D.
    Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cystic lesions with malignant potential. This review outlines current guidelines, surgical indications, outcomes, and surveillance strategies. It also highlights recent advances in minimally invasive surgery and emerging biomarkers aimed at improving risk stratification and reducing unnecessary resections.
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    COMPARISON OF MAXIMAL OXYGEN CONSUMPTION, RESTING METABOLIC RATE AND BODY COMPOSITION ANALYSIS BETWEEN AEROBIC AND ANAEROBIC SPORTS
    (ANTHROPOLOGICAL SOCIETY OF SERBIA, 2023-09-27)
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    The aim of this study is to compare the values of maximal oxygen consumption (VO2 max), resting metabolic rate (RMR) and body composition analysis between aerobic and anaerobic sports. 90 male athletes (25,34 ±5,6 age; 179,78±6.9 height/cm; 78,66±6,9 weight/kg and 24,34±2,75 BMI/ kg/m2) were tested for this study. The athletes were divided in 2 groups, I group- aerobic sports (endurance) (n=63), II group- anaerobic sports (strength) (n=26). Height was measured with stadiometer - СЕКА, body composition by means of bioelectrical impedance analysis - InBody 720, (Great Britain), RMR with indirect calorimetry- Fit Mate, COSMED, (Italy) and VO2 max with ergometric test Bruce on treadmill (ergo _run medical_α 24). Results showed that anaerobic athletes have significantly higher values of weight (83 ± 12kg) , BMI (26 ± 3 kg/m2) and body fat percentage-PBF (15 ± 8%), compared to aerobic athletes: weight (76 ±7 kg), BMI (23±1,5 kg/m2) and PBF (12 ±3 %). Aerobic athletes have significantly higher values skeletal muscle mass percentage -SMM (50 ±2%) and VO2 max (50,1 ± 4 ml/kg/min) (p<0,05) and higher values of RMR (2265 ±276 kcal/day) compared to anaerobic athletes: % SMM (48 ± 4%), VO2 max (45,9± 5 ml/kg/min) and RMR (2258 ± 314 kcal/day).Kako bi postigli više vrednosti VO2 max i bolju performasnu sportisti kombinuju submaksimalne i maksimalne trenažne sesije. To keep high SMM, endurance athletes need to have higher calorie intake. To achieve higher VO2 max values and better performance athletes tend to have combined submaximal and maximal training sessions.
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    BODY COMPOSITION AND RESPIRATORY PARAMETER ANALYSIS AT FOOTBALL PLAYERS
    (ANTHROPOLOGICAL SOCIETY OF SERBIA, 2023-09-27)
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    Pulmonary function tests (PFTs) are commonly used for evaluating respiratory status and managing persons with known pulmonary disease. They have become part of routine health examinations in respiratory, occupational, and sports medicine, and in public-health screening. The results of PFTs are interpreted in relation to normal range reference values, as recommended by the guidelines of the American Thoracic Society (ATS) and the European Community forCoal and Steel (ECCS). Spirometry is a gold standard pulmonary function test that measureshow an individual inhales or exhales volumes of air as a function of time. It is the mostimportant and most frequently performed pulmonary function testing procedure, having becomeindispensable for the prevention, diagnosis, and evaluation of various respiratory impairments. Anumber of 61 football players were divided into 2 groups according to their age, 13 (13.85 ± 3.26) and27 years (23.82 ± 3.32). This study was organized by the Institute of Medical, Experimentaland Applied Physiology and Anthropology, Medical faculty – UKIM, Skopje. The spirometry method was performed with the Spirobank II spirometer (Rome, Italy), for the followingparameters: forced vital capacity (FVC), forced expiratory volume in the first second (FEV1),and the ratio FEV1/FVC ratio.Body composition analyzer InBody 720, Great Britain, was usedto determine body weight (kg), body height (cm), body mass index - BMI weight (kg / m 2 ),skeletal muscle mass SMM (kg) and the amount of proteins (kg) and minerals (kg). We did notfind any statistically significant differences for forced vital capacity (FVC), forced expiratoryvolume in the first second (FEV1), and the ratio FEV1/FVC ratio.
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    BODY COMPOSITION ANALYSIS IN FEMALE FITNESS COMPETITORS AND RECREATIONISTS
    (ANTHROPOLOGICAL SOCIETY OF SERBIA, 2023-09-27)
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    Adam Gligoroski
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    Zivko Stojchev
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    The fitness became very popular sport for women globally, whether they are involved in exercise as leisure activity or for competitive reasons.Body shape and suitable body composition is a primary goal for all participants in fitness programs, recreationists and competitors. The aim of this study isto compare the body composition characteristics of female fitness and bodybuilding recreationists and competitors. This study involved 39 adult women, aged 18 to 40, who were divided into four groups: women competitors (N= 9), recreational women (N=30), Body composition was analyzed with bioelectrical impedance analysis, InBody 720. The comparison of BIA obesity parameters showed that BMI was insignificantly different between competitors and recreationists, 22.5 vs 23.03 ( p=0.659). The fitness competitors showed higher volume of body fluids (ICW and ECW), higher protein and mineral components. Body fat mass (BFM) was statistically greater in recreationists comparing the competitors 18.58 kg vs 12.47 kg. Mean values of body fat percentage were also statistically higher in recreationists in comparison with the competitors, 27.25% vs 16.39%. Fitness competitorshad a significantly higher fat-free mass, i.e. muscle component, and significantlylower fat component. Recreational exercisers had significantly higher parameters of obesity (body fat mass, BF% and WHR) than fitness contestants.
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    PLUCNA EMBOLIJA U BOLESNIKA S LEIDENOVOM TROMBOFILIJOM FAKTORA V I PSORIJAZOL: PRIKAZ SLUCAJ.
    (Association of pulmologists from Republika Srpska, 2023-05)
    Baloski Marjan
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    Bushev Jane
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    Brishkoska-Boshkovski Vesna
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    Hasan Taner
    Cilj: Genetski faktori rizika pove!avaju rizik venske tromboembolije. Poremecaji u sintezi ili aktivnosti faktora koagulacije. Faktor V Leiden, protrombin (20210-A), antitrombinski deficit, deficit proteina C i proteina S i hiperhomocisteinemija najcesce su mutacije gena povezanih sa venskim tromboembolijom . Uvod : Psorijaza i prisutvo mutacije trombofilnih gena povecava rizik venske tromboembolije. Prethodna venska tromboembolija je jedan od najjacih faktora rizika, cak i kod pacijenata koji su aktivno leceni antikoagulansom. Psorijaza je kompleksna imuno posredovana bolest, povezana sa kardiovaskularnim rizikom, markerima hiperkoagulabilnosti i povisenim homocisteinom. Mnogo izvjestaja o opservacijama sugerira povecanu ucestalost venskih trombembolickih dogadaja kod pacijenata sa psorijazom. Nalazi: Prikazujemo bolesnika s nasljednom trombofilijom i kronicnom difuznom psorijazom kompliciranom plu!nom embolijom. Analiza DNK ukazuje na prisutnost homozigoze za mutaciju faktora V Leidena. Dermatoloska anamneza je pozitivna na psorijazu. Zaklju!ak: Prikaz ovog slucaja ukazuje na povezanost venske tromboembolije i psorijaze. Pacijenti sa naslednom trombofilijom, psorijazom I plucnim tromboembolizmom, imaju visoki rizik od razvoj venske tromboembolije.
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    TROPONIN I VISOKE OSETLJIVOSTI I DUŽINA BORAVKA U BOLNICI KOD AKUTNO OTROVANIH PACIJENATA SA RABDOMIOLIZOM
    (2023-05)
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    Niko Bekarovski
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    Andon Chibishev
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    Cardiac troponins (cTn) are regulatory proteins that play a pivotal role in the interaction between actin and myosin, controlling the contraction and relaxation of skeletal and cardiac muscle. The high-sensitivity cardiac troponin I assay is not entirely specific for myocardial injury. The aim is to determine the role of hs–TroponinI on the hospital length of stay in patients with rhabdomyolysis acutely intoxicated with psychotropic and chemical substances. In a clinically controlled prospective study, 140 patients with rhabdomyolysis were divided into two groups depending on the intoxicating substance (psychotropic or chemical). Rhabdomyolysis was defined as a creatine kinase (CK)>250 U/L according to the poisoning severity score (PSS). We analyze hs–TroponinI in both groups upon admission. In patients with rhabdomyolysis in the group of psychotropic intoxications, the level of hs-TnI on admission significantly affected the length of hospitalization in 17.7% (R2 = 0.177). Increasing the value of the hs-TnI level per unit on admission increased the length of hospital stay by an average of 0.016 days. In patients with rhabdomyolysis in the chemical intoxication group, the hs-TnI level on admission has no influence on the hospital length of stay (R2 = 0.000). The increased hs-TnI level on the first day did not affect the hospital length of stay variability. In patients with rhabdomyolysis acutely intoxicated with psychotropic substances, hs-Tn I can be used to predict the length of hospital stay
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    CANNABIS AND AMPHETAMINE USE IN PATIENTS ON BUPRENORPHINE MAINTENANCE TREATMENT
    (2023-05)
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    Niko Bekarovski
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    Andon Chibishev
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    Polydrug abuse is a known problem among patients on opioid maintenance treatment. Objective is to assess the profile of patients on buprenorphine substitution treatment who use cannabis, amphetamine or cannabis and amphetamine in parallel. This study was conducted in 2021 year at University Clinic for toxicology, Skopje and has a prospective cohort design that included 112 patients with opioid use disorder on buprenorphine maintenance treatment. The data were collected according to a previously designed self-administered questionnaire adapted according to the “treatment demand indicator”. The following variables were analyzed: gender, age, duration of opioid use disorder, route of administration, duration of buprenorphine treatment, buprenorphine dose, cannabis and amphetamine use. The majority of patients were male (88.4%). The mean age of patients was 38.7±4.3 years. The average duration of opioid use disorder was 16.8±6.8 years; the duration of buprenorphine treatment was 6.3±3.3 years; buprenorphine dose was 12.5±4.9mg. Parallel use of buprenorphine with cannabis was declared in 43.7% of the patients and they were significantly younger compared to others (p=0.014). A combination of buprenorphine with amphetamine was used in 14.3% with significantly younger ages compared to others (p=0.003). Buprenorphine with both cannabis and amphetamine was practiced in 15.2% of the patients. No significant correlation was found between other variables of the studied group and the parallel use of cannabis and amphetamine. Almost half of the patients on buprenorphine substitution treatment reported parallel use of cannabis. The patients who declared parallel use of cannabis and amphetamines were of younger age compared to others.