Faculty of Medicine

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    РЕДОК СЛУЧАЈ НА ДЕРМОИДНА ЦИСТА (МАТУРЕН ЦИСТИЧЕН ТЕРАТОМ НА ОВАРИУМ) КАЈ ПАЦИЕНТКА ВО ПОСТМЕНОПАУЗА
    (SHMSHM - AAMD (Association of the Albanian Doctors from Macedonia), 2025)
    Bekim Dika
    ;
    Оваријалните тератоми се најчестите тумори со потекло од герминативните клетки на овариумите (95% од сите тумори на герминативните клетки и 20% од сите тумори на јајниците). Тие ретко се детектираат во постменопаузална возраст и понекогаш се поврзани со прекумерно производство на андрогени [3]. Овие тумори содржат зрели ткива кои потекнуваат од ектодерм, мезодерм и/или ендодерм. Прикaжуваме случај на 60-годишна пациентка, која беше примена во нашата болница со абдоминална болка, зголемен абдомен и опиплива карлична маса. На компјутеризирана томографија се прикажа голема туморска формација во малата карлица со локализација над матката, со дијаметар од 10x15 см, со тенок ѕид, делумни прегради и со притисок врз околните структури. Се направи лапаротомија и тотална абдоминална хистеректомија со билатерална аднексектомија. На пресек, цистата беше исполнета со лој и влакна, ѕидот беше дебел 2-3 мм, со мазна луминална површина, во еден дел со видлив цврст нодуларен дел со дијаметар од 4,5 см, кој имаше структура од масно ткиво и потврдо ‘рскавично ткиво (Teratoma maturum cysticum ovarii). Микроскопската анализа ја потврди дијагнозата. Постоперативниот тек беше уреден, без компликации.
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    PREVALENCE OF ANEMIA IN PATIENTS WITH MISSED ABORTION
    (Македонско лекарско друштво = Macedonian medical association, 2025-09)
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    Jasmina Chelebieva
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    ;
    Bekim Dika
    Introduction: Miscarriage (abortion), 85% of which may happen during the first trimester, is one of the most common adverse pregnancy outcomes. Almost half of miscarriages are a consequence of chromosomal abnormalities. The risk factors include advanced maternal age, comorbidities (obesity, diabetes, hypertension), previous miscarriages, smoking and inappropriate nutritional status. Anaemia is the most prominent haematological abnormality during gestation and it is a global health problem affecting nearly half of all pregnant women. Anaemia has been linked to a higher risk of adverse outcomes, including maternal mortality, stillbirth, preterm births, small-for-gestational-age (SGA). World Health Organization has defined anaemia in pregnancy as the haemoglobin (Hgb) concentration of less than 110g/L. The primary cause of anemia during pregnancy is iron deficiency secondary to chronic inadequate dietary intake and menstruation, heightened by the physiologic demands of the fetus and maternal blood volume expansion during pregnancy. The aim of our study was to determine the prevalence of anemia in women with missed abortion in the first trimester of pregnancy, who are not bleeding. Material and methods: In 80 patients with missed abortion in the first trimester of pregnancy, we determined the level of Hgb in capillary blood. Results: In 31 women (38,8%), we detected anemia (the level of Hgb below 110g/L), and 7 of them (8,8% of the total number of women) had a severe anemia with Hgb levels below 90 g/L. As pregnancy progresses, we expect this prevalence to increase. Conclusion: We want to emphasize that a large percentage of women are anemic even preconceptually and early in pregnancy, so if it is not detected and treated, the severity of anemia worsens as the pregnancy progresses.
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    ANEMIA IN PREGNANCY AND RISK FACTORS
    (Македонско лекарско друштво = Macedonian medical association, 2025-09)
    Aleksandar Nakov
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    Bekim Dika
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    Introduction: During pregnancy, there is a “dilution” of hemoglobin concentration due to the increase in plasma volume. Iron and folic acid are necessary for the development of the fetus and are transported to it, so the mother can develop anemia due to their deficiency. Anemia affects 36% of pregnant women worldwide. Of those affected, about 40% are due to iron deficiency. Iron is an essential micronutrient involved in vital processes such as erythropoiesis, immune responses, and during pregnancy in the development of the placenta and fetus. The aim of our research was to determine the prevalence of anemia in pregnancy as well as the influence of certain risk factors: age, body mass index - BMI, parity and history of taking iron supplements. Material and methods: A blood count was performed in 100 patients in the third trimester of pregnancy in order to determine the hemoglobin concentration. The patients' body weight and height (to determine BMI) were measured and data were collected about age, number of previous births, and whether they were taking iron supplements. Results: Anemia (hemoglobin level below 110g/L) was present in 42.1% of pregnant women. Anemia was significantly common in women with ≥3 births and in those not taking iron supplements. Statistically insignificant anemia was more common in women under 25 years of age and in those with a BMI below 20. Conclusion: The results of the study showed the importance of regular controls of hemoglobin levels as well as the significance of iron supplementation during pregnancy, when the needs for this element are significantly higher.
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    A CASE REPORT OF A PATIENT WITH AN ACUTE INTRAPARTAL UTERINE INVERSION
    (Македонско лекарско друштво = Macedonian medical association, 2025-09)
    Bekim Dika
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    Laureta Mena
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    Metodi Trajchevski
    Introduction. Acute inversion of uterus is a rare, but life-threatening complication of third stage of labour. Uterine inversion is defined as the turning inside out of the fundus into the uterine cavity. It’s incidence is 1:2,000–1:23,000 deliveries. Severe uterine atony, mismanagement of third stage of labour, adherent placenta are some of the common factors associated with the occurrence of acute inversion of uterus. Case report. We report a case of the 25 years old primipara. After a spontaneous delivery of the baby, during the controled cord traction, a mass appeared at the introitus of the vagina. Placenta was still attached to the uterus. A complete uterine inversion happened. Obstetric and anesthesia teams were emergency mobilized. Manual uterine reposition under general anesthesia (the Johnson maneuver) was performed 5-6 minutes after the event. The placenta was removed after the repositioning of the uterus. Massive hemorrhage occured. Uterotonic therapy was administered immediately after repositioning. The substitution therapy was administered starting 25 minutes after the event and continued in the next 24 hours: 1400ml of erythrocyte concentrate, 880ml of fresh frozen plasma and 100ml 20% albumine. The drop in the levels of hemoglobin and hematocrite 25 minutes after the inversion was Hb=64g/L (121g/L antepartum), Hct=0.17 (0.33 antepartum). 72 hours after the event this values were normalized. Vital signs were stabile, no further hemorrhage occured, and woman was discharged at the forth post delivery day. Conclusion: Early recognition and prompt treatment are important to save life of the woman. Prompt recognition of uterine inversion, its immediate manual reposition under general anaesthesia and transfusion of blood products are crucial for successful tretment. Delay in recognition and treatment can result in haemorrhagic and neurogenic shock, leading to death of a women.
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    HISTOPATHOLOGICAL FINDINGS IN PATIENTS WITH ULTRASONOGRAPHICALLY DETECTED ENDOMETRIAL POLYP
    (Македонско лекарско друштво = Macedonian medical association, 2025-09)
    Bekim Dika
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    Ivan Koprivnjak
    Introduction. Endometrial polyps are defined as the excess hyperplastic growth of endometrial glands and stroma within the uterine cavity. They vary in size from a few millimeters to several centimeters. Polyps may be found as a single lesion or multiple lesions filling the entire endometrial cavity. Endometrial polyps may be diagnosed at all ages but the highest incidence is between 40 - 49 years of age. They are considered benign but there is a small risk of malignant transformation. Thе aim of this study is to determine the correlation between the ultrasound findings of endometrial polyp and the histopathological reports. Material and methods. We analized a total of 140 histopathological reports from patients who underwent fractionated explorative curettage or hysteroscopy due to ultrasonographically diagnosed endometrial polyps. The histopathological findings showed that in 112 (80%) the diagnosis of endometrial polyp was confirmed and 78 of these were hyperplastic polyps (69.6% of the total number of endometrial polyps), 5 polyps with atypical hyperplasia (4.5%), 1 (0.9%) malignant polyp (adenocarcinoma), 5 senile polyps (4,5%). Endocervical or isthmicocervical polyp were diagnosed in 12 patients (8.6%). The remaining 28 patients (20%) had these findings: simplex endometrial hyperplasia without atypia (6 patients), complex endometrial hyperplasia without atypia (1), complex endometrial hyperplasia with atypia (1 patient), submucosal myoma (3), adenomyoma (1), prolonged and inadequate estrogen action (8), deficient secretory phase (3), chronic cervicitis (3), and normal endometrium in 2 patients. Conclusion: Transvaginal ultrasound is the first line of investigation while evaluating the endometrium. Its accuracy is limited in the diagnosis of focal endometrial lesions, so the further investigation is needed. Hysteroscopy is the gold standard for accurate evaluation of intracavitary pathology like submucous fibroid, polyps or anomalies.
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    A CASE OF A LYME DISEASE IN THE SECOND TRIMESTER OF PREGNANCY
    (Македонско лекарско друштво = Macedonian medical association, 2025-09)
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    Anamarija Shpishikj Pushevska
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    Pranvera Izairi
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    Arta Islami Zulfiu
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    Bekim Dika
    Introduction: Lyme disease is the most common tick-borne disease in North America and Europe and it is caused by spirochetal bacteria Borelia burgdorferi. Early symptoms of infection include a characteristic rash (erythema migrans), fever, headache and lethargy. If untreated, the disease may affect the heart, nervous system and joints. Regardless of whether maternal exposure to B. burgdorferi occurs before conception or during pregnancy, it does not appear to be associated with fetal death, prematurity or risk of congenital malformations. Even documented infection of the placenta with B. burgdorferi has not been linked to adverse pregnancy outcomes. Also, there have been no reported cases of transmission of B. burgdorferi via breast milk. Antibiotics used during pregnancy are amoxicillin or cephalosporins, 14-21 days. Case report: A 24-year-old primigravida, at 23 weeks of gestation, reported that 3 weeks earlier she had been bitten by a tick that had not been removed by a surgeon. A change appeared as a red ring of about 10 cm in the gluteal region on the right, as well as joint pain, without fever. She was examined by an infectious disease specialist. Serological tests were performed and a high titer of IgG and IgM antibodies for Borelia burgdorferi sensu lato were detected. Antibiotic therapy Amp. Ceftriaxone 2gr/day was administered for 14 days, which prevented further complications in mother or fetus. Conclusion: With this case, we want to point out that Lyme borreliosis is present, that a tick bite is serious and requires an examination by a surgeon and an infectious disease specialist, in order to properly remove the tick and prevent the occurrence of this disease, which is possible even during pregnancy. It is also important to be aware of its symptoms, in order to start antibiotic therapy before more serious complications arise.
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    LARGE FIBROEPITHELIAL VAGINAL POLYP WITH VAGINAL INTRAEPITHELIAL NEOPLASIA (VAIN1) – CASE REPORT
    (2022-05)
    Dimitar Georgiev
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    Bashkim Ismaili
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    Bekim Dika