Faculty of Medicine
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Item type:Publication, SQUAMOUS CELL CARCINOMA ARISING IN A KELOID SCAR: A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Angelovska TIntroduction: Keloids are characterized by abnormal fibroblast proliferation and excessive collagen deposition. While typically benign, they have been recognized as potential predisposing factors for cutaneous neoplasia. Case Presentation: We present a rare case of squamous cell carcinoma (SCC) arising within a keloid scar in a 38-year-old female with a history of exuberant keloid formation on the feet. Histopathological examination of the excised lesion revealed moderately differentiated SCC developing within keloid tissue, marked by invasive nests of atypical squamous cells and keratin pearl formation embedded in dense keloidal stroma. Conclusion: Although exceedingly rare, malignant transformation of keloid scars into SCC can occur, particularly in lesions exposed to chronic irritation, inflammation, ulceration, repeated trauma, or ultraviolet radiation. Clinicians should maintain a high index of suspicion when evaluating morphological changes in long-standing keloids. Early biopsy of suspicious lesions is crucial for timely diagnosis and appropriate management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ASSOCIATION BETWEEN LOW BIRTH WEIGHT AND MODE OF DELIVERY IN TERM PREGNANCY(Association of Albanian Medical Doctors in Macedonia, 2025-10) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, UMBILICAL CORD CORTISOL LEVELS IN TERM AND LATE-PRETERM NEWBORNS(Macedonian Association of Anatomists and Morphologists, 2025); ; Baevska Vuchkovikj, TatjanaCortisol, a glucocorticoid hormone secreted by the adrenal cortex, plays a pivotal role in human physiology, particularly in stress response regulation, immune function, and metabolic homeostasis. In the perinatal period, cortisol becomes a critical determinant of neonatal outcomes, as it drives the maturation of key fetal organs and facilitates the transition from intrauterine to extra uterine life. A surge in fetal cortisol levels during late gestation is integral to the development of the lungs, liver, and brain, which are essential for postnatal survival. Moreover, the umbilical cord, as the primary channel of maternal-fetal exchange, provides an invaluable window into the hormonal state of the fetus at birth. An observational prospective study analyzing umbilical cord blood cortisol levels, focusing on their associations with gestational age, was conducted at the Mother Teresa Hospital in Skopje, and 88 samples were obtained for analysis. The aim was to compare cortisol levels in healthy and appropriate for gestational age (AGA) newborns, depending on their gestational age. The results showed a mean cortisol level of 93.41 [95%CI 82.72 – 104.10]. In term infants the mean cortisol level was significantly higher, with a mean value of 100.60 [95%CI 88.940 – 112.259], than in preterm ones where mean cortisol level was 51.91 [95%CI 40.528 – 63.301], with a statistically significant difference (p<0.0012). The significant associations between cortisol levels and gestational age highlight the potential utility of umbilical cord blood cortisol as a biomarker for assessing neonatal stress and adaptation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PRIMARY SINONASAL MENINGIOMA MIMICKING BENIGN NASAL LESIONS - A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Jovcheva, AIntroduction: Primary extracranial meningiomas are rare neoplasms, accounting for less than 2% of all meningiomas. The sinonasal tract represents an uncommon site of origin and frequently presents diagnostic challenges due to nonspecific clinical and radiological features. Case Presentation: A 79-year-old male presented with a unilateral nasal cavity mass. Computed tomography revealed diffuse polypoid mucosal thickening with near-complete opacification of paranasal sinuses and obliteration of aeration. Histopathology showed a circumscribed neoplastic proliferation arranged in lobular and whorled patterns beneath intact respiratory epithelium. Tumor cells displayed uniform morphology with oval nuclei, eosinophilic cytoplasm, and inconspicuous nucleoli. Psammoma bodies and delicate vascular channels were present. Necrosis, nuclear atypia, and mitotic activity were absent. Immunohistochemistry showed strong positivity for epithelial membrane antigen (EMA), vimentin, p63, and progesterone receptor, while cytokeratin AE1/AE3, CD34, smooth muscle actin (SMA), S100, SOX10, desmin, and synaptophysin were negative. The proliferative index (Ki-67) was <5%. Discussion: Extracranial meningiomas are rare neoplasms with poorly understood histogenesis, presumably arising from displaced meningothelial cells during embryonic development. Sinonasal meningiomas may mimic other nasal masses including nasal polyps, inverted papilloma, olfactory neuroblastoma, or carcinoma. In this case, the morphological features combined with the supportive immunohistochemical profile confirmed the diagnosis of WHO Grade I meningothelial meningioma with angiomatous features. Conclusion: Primary sinonasal meningioma should be included in the differential diagnosis of sinonasal masses. Accurate recognition through comprehensive histopathological and immunohistochemical analysis is essential for proper diagnosis and management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, РЕДОК СЛУЧАЈ НА ДЕРМОИДНА ЦИСТА (МАТУРЕН ЦИСТИЧЕН ТЕРАТОМ НА ОВАРИУМ) КАЈ ПАЦИЕНТКА ВО ПОСТМЕНОПАУЗА(SHMSHM - AAMD (Association of the Albanian Doctors from Macedonia), 2025) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE OF ANEMIA IN PATIENTS WITH MISSED ABORTION(Македонско лекарско друштво = Macedonian medical association, 2025-09); ; ; Bekim DikaIntroduction: Miscarriage (abortion), 85% of which may happen during the first trimester, is one of the most common adverse pregnancy outcomes. Almost half of miscarriages are a consequence of chromosomal abnormalities. The risk factors include advanced maternal age, comorbidities (obesity, diabetes, hypertension), previous miscarriages, smoking and inappropriate nutritional status. Anaemia is the most prominent haematological abnormality during gestation and it is a global health problem affecting nearly half of all pregnant women. Anaemia has been linked to a higher risk of adverse outcomes, including maternal mortality, stillbirth, preterm births, small-for-gestational-age (SGA). World Health Organization has defined anaemia in pregnancy as the haemoglobin (Hgb) concentration of less than 110g/L. The primary cause of anemia during pregnancy is iron deficiency secondary to chronic inadequate dietary intake and menstruation, heightened by the physiologic demands of the fetus and maternal blood volume expansion during pregnancy. The aim of our study was to determine the prevalence of anemia in women with missed abortion in the first trimester of pregnancy, who are not bleeding. Material and methods: In 80 patients with missed abortion in the first trimester of pregnancy, we determined the level of Hgb in capillary blood. Results: In 31 women (38,8%), we detected anemia (the level of Hgb below 110g/L), and 7 of them (8,8% of the total number of women) had a severe anemia with Hgb levels below 90 g/L. As pregnancy progresses, we expect this prevalence to increase. Conclusion: We want to emphasize that a large percentage of women are anemic even preconceptually and early in pregnancy, so if it is not detected and treated, the severity of anemia worsens as the pregnancy progresses. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, INCARCERATED INCISIONAL HERNIA: AN UNUSUAL PRESENTATION OF LIPOSARCOMA MYXOIDES METASTATICUM(Македонско лекарско друштво = Macedonian medical association, 2025-09); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANEMIA IN PREGNANCY AND RISK FACTORS(Македонско лекарско друштво = Macedonian medical association, 2025-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A CASE REPORT OF A PATIENT WITH AN ACUTE INTRAPARTAL UTERINE INVERSION(Македонско лекарско друштво = Macedonian medical association, 2025-09); Metodi TrajchevskiIntroduction. Acute inversion of uterus is a rare, but life-threatening complication of third stage of labour. Uterine inversion is defined as the turning inside out of the fundus into the uterine cavity. It’s incidence is 1:2,000–1:23,000 deliveries. Severe uterine atony, mismanagement of third stage of labour, adherent placenta are some of the common factors associated with the occurrence of acute inversion of uterus. Case report. We report a case of the 25 years old primipara. After a spontaneous delivery of the baby, during the controled cord traction, a mass appeared at the introitus of the vagina. Placenta was still attached to the uterus. A complete uterine inversion happened. Obstetric and anesthesia teams were emergency mobilized. Manual uterine reposition under general anesthesia (the Johnson maneuver) was performed 5-6 minutes after the event. The placenta was removed after the repositioning of the uterus. Massive hemorrhage occured. Uterotonic therapy was administered immediately after repositioning. The substitution therapy was administered starting 25 minutes after the event and continued in the next 24 hours: 1400ml of erythrocyte concentrate, 880ml of fresh frozen plasma and 100ml 20% albumine. The drop in the levels of hemoglobin and hematocrite 25 minutes after the inversion was Hb=64g/L (121g/L antepartum), Hct=0.17 (0.33 antepartum). 72 hours after the event this values were normalized. Vital signs were stabile, no further hemorrhage occured, and woman was discharged at the forth post delivery day. Conclusion: Early recognition and prompt treatment are important to save life of the woman. Prompt recognition of uterine inversion, its immediate manual reposition under general anaesthesia and transfusion of blood products are crucial for successful tretment. Delay in recognition and treatment can result in haemorrhagic and neurogenic shock, leading to death of a women. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A CASE OF A POSTMENOPAUSAL WOMEN WITH DIFFERENTIATED VULVAR INTRAEPITHELIAL NEOPLASIA (dVIN) – HPV INDEPENDANT(Македонско лекарско друштво = Macedonian medical association, 2025-09); ;