SQUAMOUS CELL CARCINOMA ARISING IN A KELOID SCAR: A CASE REPORT AND LITERATURE REVIEW
Journal
Academic Medical Journal
Date Issued
2025
Author(s)
Boshkova E
Angelovska T
Abstract
Introduction: Keloids are characterized by abnormal fibroblast proliferation and excessive
collagen deposition. While typically benign, they have been recognized as potential
predisposing factors for cutaneous neoplasia.
Case Presentation: We present a rare case of squamous cell carcinoma (SCC) arising within a
keloid scar in a 38-year-old female with a history of exuberant keloid formation on the feet.
Histopathological examination of the excised lesion revealed moderately differentiated SCC
developing within keloid tissue, marked by invasive nests of atypical squamous cells and
keratin pearl formation embedded in dense keloidal stroma.
Conclusion: Although exceedingly rare, malignant transformation of keloid scars into SCC can
occur, particularly in lesions exposed to chronic irritation, inflammation, ulceration, repeated
trauma, or ultraviolet radiation. Clinicians should maintain a high index of suspicion when
evaluating morphological changes in long-standing keloids. Early biopsy of suspicious lesions
is crucial for timely diagnosis and appropriate management.
collagen deposition. While typically benign, they have been recognized as potential
predisposing factors for cutaneous neoplasia.
Case Presentation: We present a rare case of squamous cell carcinoma (SCC) arising within a
keloid scar in a 38-year-old female with a history of exuberant keloid formation on the feet.
Histopathological examination of the excised lesion revealed moderately differentiated SCC
developing within keloid tissue, marked by invasive nests of atypical squamous cells and
keratin pearl formation embedded in dense keloidal stroma.
Conclusion: Although exceedingly rare, malignant transformation of keloid scars into SCC can
occur, particularly in lesions exposed to chronic irritation, inflammation, ulceration, repeated
trauma, or ultraviolet radiation. Clinicians should maintain a high index of suspicion when
evaluating morphological changes in long-standing keloids. Early biopsy of suspicious lesions
is crucial for timely diagnosis and appropriate management.
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