Faculty of Veterinary Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/21
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Item type:Publication, Prevalence, Risk Factors, and Zoonotic Potential of Intestinal Parasites in Shelter Dogs in North Macedonia: A Cross-Sectional Study(Walter de Gruyter GmbH, 2026-03-01) ;Chapkunovska, Bojana; ; ; Vlahov, Jane - Some of the metrics are blocked by yourconsent settings
Item type:Publication, First Report of Bovine Coenurosis in North Macedonia(Walter de Gruyter GmbH, 2024-01-18); ; ;Dimitrievski, Boris; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NEW RECORDS OF THE ASIAN TIGER MOSQUITO (AEDES ALBOPICTUS) IN NORTH MACEDONIA(Walter de Gruyter GmbH, 2020-10-01); ;Djadjovski, Igor; ;Popova, Zagorka - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CYSTIC ECHINOCOCCOSIS IN SLAUGHTERED CATTLE AND SHEEP FROM NORTH MACEDONIA(Walter de Gruyter GmbH, 2022-03-15); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Seroprevalence of canine leishmaniosis in asymptomatic dogs in Kosovo(Springer Science and Business Media LLC, 2022-12-20) ;Xhekaj, Betim; ;Sherifi, Kurtesh ;Rexhepi, AgimBizhga, Bejo - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Species composition, distribution, and host associations of ixodid ticks in domestic animals on lowland pastures in North Macedonia(Elsevier BV, 2026-04-03) ;Chapkunovska, Bojana; ;Matevski, Ivan ;Vlahov, Jane - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Mirusha virus: A novel sand fly-borne phlebovirus with evidence of neutralizing antibodies in humans and dogs in Kosovo(Elsevier BV, 2026-12) ;Jakupi, Xhevat ;Kurum, Elif ;Xhekaj, Betim ;Hoxha, InaWalochnik, Julia - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prevalence, Risk Factors, and Zoonotic Potential of Intestinal Parasites in Shelter Dogs in North Macedonia: A Cross-Sectional Study(Walter de Gruyter GmbH, 2026-03-03) ;Chapkunovska, Bojana; ; ; Vlahov, Jane - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Genetic characterisation of Echinococcus granulosus sensu lato infecting ruminants in the Republic of North Macedonia(2025-12); ; ; ;Zagorka Popova HristovskaBetim Xhekaj - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Sand fly-associated phlebovirus with evidence of neutralizing antibodies in humans and dogs in Kosovo(Informa UK Limited, 2026-01) ;Kurum, Elif ;Jakupi, Xhevat ;Xhekaj, Betim ;Platzgummer, KatharinaHoxha, InaThe Balkan Peninsula is a hotspot for sand fly-borne phleboviruses (SbPVs), yet Kosovo had no confirmed viral detection invectors despite serological evidence of human and animal exposure. This study reports the discovery, genetic characterization, and seroprevalence of a novel phlebovirus, Grapi virus (GRPV), in Kosovo. Entomological surveys (2022-2023) collected 3,575 sand flies across seven districts. Morphological and molecular identification revealed Phlebotomus perfiliewi as the dominant species. Pan-phlebovirus RT-PCR screening identified GRPV in seven pools. Complete genome sequencing confirmed its tripartite genome, sharing 97.55-98.70% nucleotide identity with Bregalaka virus, classifying it within the Phlebovirus adanaense species. Phylogenetic analysis revealed segment-specific ancestry, suggesting recombination events between Bregalaka virus, Adana virus, and Medjerda Valley virus. Seroprevalence studies using neutralization assays detected GRPV-specific antibodies in 13.0% of humans and 2.7% of dogs. Human seropositivity peaked in adolescents and declined with age, while dogs showed higher rates in purebred and unhealthy ones. No cross-reactivity with Toscana or Sicilian viruses was observed, indicating distinct immunological responses. GRPV replicated efficiently in Vero cells and more slowly in mosquito cells, suggesting mammalian adaptation. GRPV detection in Kosovo underscores the role of the Balkan region in SbPV emergence. GRPV zoonotic potential is supported by the anthropophilic feeding behaviour of Ph. perfiliewi and by the significant seroprevalence rates in dogs and humans. Limitations include biased human/dog sampling and sparse northern Kosovo coverage. Investigating GRPV pathogenicity and ecology; integrated surveillance and diagnostics are essential for the future.
