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Epidemiology and impact of frailty in patients with atrial fibrillation in Europe
(Oxford University Press (OUP), 2022-08)
Proietti, Marco
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Romiti, Giulio Francesco
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Vitolo, Marco
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Harrison, Stephanie L
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Lane, Deirdre A
Background: Frailty is a medical syndrome characterised by reduced physiological reserve and increased vulnerability to stressors. Data regarding the relationship between frailty and atrial fibrillation (AF) are still inconsistent. Methods A 40-item frailty index (FI) was built according to the accumulation of deficits model in the AF patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry. Association of baseline characteristics, clinical management, quality of life, healthcare resources use and risk of outcomes with frailty was examined. Results Among 10,177 patients [mean age (standard deviation) 69.0 (11.4) years, 4,103 (40.3%) females], 6,066 (59.6%) were pre-frail and 2,172 (21.3%) were frail, whereas only 1,939 (19.1%) were considered robust. Baseline thromboembolic and bleeding risks were independently associated with increasing FI. Frail patients with AF were less likely to be treated with oral anticoagulants (OACs) (odds ratio 0.70, 95% confidence interval 0.55–0.89), especially with non-vitamin K antagonist OACs and managed with a rhythm control strategy, compared with robust patients. Increasing frailty was associated with a higher risk for all outcomes examined, with a non-linear exponential relationship. The use of OAC was associated with a lower risk of outcomes, except in patients with very/extremely high frailty. Conclusions In this large cohort of AF patients, there was a high burden of frailty, influencing clinical management and risk of adverse outcomes. The clinical benefit of OAC is maintained in patients with high frailty, but not in very high/extremely frail ones.
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SARS-COV-2 INFECTION: CARDIAL AND MULTI-ORGAN INVOLVEMENT
(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2022-12)
Furnadziski, Aleksandar
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Mitevski, Goran
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Nikolovski, Robert
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SARS-COV-2 is a single-strain RNA virus that attacks primarily the respiratory system. The second most commonly affected system is the cardiovascular. Often it attacks multiple organ systems causing multi-organ failure. Atrial fibrillation (AF) is the most common sustained supraventricular arrhythmia in acute settings of COVID-19 infection and is associated to more complications and mortality rates. The presence of AF in patients with COVID-19 pneumonia should be managed with increased attention to prevent adverse outcomes. COVID-19 may be a cause of multiple organ damage in some infected patients.
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Clinical utility and prognostic implications of the novel 4S-AF scheme to characterize and evaluate patients with atrial fibrillation: a report from ESC-EHRA EORP-AF Long-Term General Registry
(Oxford University Press (OUP), 2022)
Ding, Wern Yew
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Proietti, Marco
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Boriani, Giuseppe
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Fauchier, Laurent
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Blomström-Lundqvist, Carina
The 4S-AF classification scheme comprises of four domains: stroke risk (St), symptoms (Sy), severity of atrial fibrillation (AF) burden (Sb), and substrate (Su). We sought to examine the implementation of the 4S-AF scheme in the EORP-AF General Long-Term Registry and compare outcomes in AF patients according to the 4S-AF-led decision-making process.
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Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry
(Oxford University Press (OUP), 2019)
Boriani, Giuseppe
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Proietti, Marco
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Laroche, Cécile
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Fauchier, Laurent
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Marin, Francisco
In recent years, stroke prevention in patients with atrial fibrillation (AF) has radically changed, with increasing use of non-vitamin K antagonist oral anticoagulants (NOACs). Contemporary European data on AF thromboprophylaxis are needed.
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Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EURObservational research programme in atrial fibrillation general long-term registry
(Wiley, 2022-07)
Malavasi, Vincenzo L
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Vitolo, Marco
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Proietti, Marco
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Diemberger, Igor
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Fauchier, Laurent
The management of patients with atrial fibrillation (AF) and malignancy is challenging given the paucity of evidence supporting their appropriate clinical management.
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Impact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry
(Wiley, 2022-06)
Ding, Wern Yew
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Potpara, Tatjana S
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Blomström-Lundqvist, Carina
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Boriani, Giuseppe
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Marin, Francisco
Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF.
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Arrhythmias induced cardiomyopathy - reversible dilated cardiomyopathy in patients with atrial fibrillation/flutter with fast ventricular rate
(Macedonian Society of Cardiology, 2014)
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Arnaudova-Dezhulovikj F.
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Kamcevska-Dobrkovic L.
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Otljanska M
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Novel anticoagulants in atrial fibrillation: focused update
(European Society of Cardiology, 2013-07-15)
Novel oral anticoagulants are safer than Vitamin K antagonists (warfarin) in respect to the occurrence of bleeding, especially in terms of intracranial hemorrhage. Furthermore they are non-inferior and to a certain degree are superior in comparison to warfarin, when it comes to the prevention of ischemic stroke in patients with atrial fibrillation (AF).

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