Faculty of Medicine

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Platelet-rich plasma as a promising bioscaffold for enhancing peripheral nerve regeneration: An experimental study in a rat sciatic nerve model
(Journal of Biological Methods, 2025)
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Aleksovski, Boris
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Tusheva, Sofija
Despite advancements in surgical treatments, impairments persist after peripheral nerve injuries, prompting a shift in research toward the microenvironment of injured axons. Platelet-rich plasma (PRP), rich in growth factors and derived from autologous blood, emerges as a potential candidate to accelerate nerve healing.
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SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms
(Elsevier BV, 2018-05)
Aleksovski, Boris
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Neceva, Violeta
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Vujović, Viktorija
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Adverse effects with bleeding disorders are often associated with the administration of SSRI in depression, although the exact mechanisms remain contradicting. This study is aimed at detecting and exploring the mechanisms of SSRI-induced changes in platelet reactivity in non-responding patients with Recurrent Depressive Disorder (RDD) and life-long exposure to antidepressants.
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Prognostic values of peripheral glutamate and TNF levels in patients with intracerebral haemorrhage
(Scitechnol Biosoft Pvt. Ltd., 2018)
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Aleksovski, Boris
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Rendevska Mihajlovska, Ana
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Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume
(VM Media SP. zo.o VM Group SK, 2018-03)
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Aleksovski, Boris
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Stojanov, Dragan
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Aleksovski, Vasko
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Mihajlovska Rendevska, Ana
We aimed to evaluate the prognostic values, contribution and interactions of the peripheral blood plasma glutamate and tumor-necrosis factor-α (TNF-α) levels toward the formation of the perifocal edema in patients with intracerebral hemorrhage (ICH).
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Surgical Outcome in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage
(Walter de Gruyter GmbH, 2017-12-01)
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Stojanov, Dragan
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Aleksovski, Boris
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Mihajlovska Rendevska, Ana
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<jats:title>Summary</jats:title> <jats:p>The aim of the paper was to evaluate the surgical outcome in patients with spontaneous supratentorial intracerebral hemorrhage (ICH) after surgical intervention, in respect to the initial clinical conditions, age, sex, hemispheric side and anatomic localization of ICH. Thirty-eight surgically treated patients with spontaneous supratentorial intracerebral hemorrhage were included in the study. The surgical outcome was evaluated three months after the initial admission, according to the Glasgow Outcome Scale (GOS). The surgical treatment was successful in 14 patients (37%), whereas it was unsuccessful in 24 patients (63%). We have detected a significant negative correlation between the Glasgow Coma Scale (GCS) scores on admission and the GOS scores after three months, suggesting worse neurological outcome in patients with initially lower GCS scores. The surgical outcome in patients with ICH was not affected by the sex, the hemispheric side and the anatomic localization of ICH, but the age of the patients was estimated as a significant factor for their functional outcome, with younger patients being more likely to be treated successfully. The surgical outcome is affected from the initial clinical state of the patients and their age. The treatment of ICH is still an unsolved clinical problem and the development of new surgical techniques with larger efficiency in the evacuation of the hematoma is necessary, thus making a minimal damage to the normal brain tissue, as well as decreasing the possibility of postoperative bleeding.</jats:p>
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Modeling prognostic factors for poor neurological outcome in conservatively treated patients with intracerebral hemorrhage: A focus on TNF-α
(Elsevier BV, 2018-09)
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Aleksovski, Boris
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Stojanov, Dragan
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Mihajlovska Rendevska, Ana
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Aleksovski, Vasko
Prognostic models for Intracerebral hemorrhage (ICH), mainly based on clinical evaluation, have remained inherently confounded by subjective scoring assessments and limited accuracy. In this study, we aimed at assessing the risk for poor outcome after ICH based on peripheral biochemical markers (TNF-α, glutamate and glucose) and radiological variables (both at admission and five days after patient's care), for modeling purposes of prognostication.
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Effects of data transformation on multivariate analyses in intracerebral hemorrhage
(Macedonian Pharmaceutical Association, 2016)
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Aleksovski, Boris
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Kolevska, Milena
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Stojanov, Dragan
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<jats:p>Multivariate statistical approaches have been increasingly applied in hemorrhagic stroke data analysis. Nevertheless, several aspects regarding their relevance and validity in respect of the application of data transformations have not been studied in details. This paper examines the effects of different data transformations in the standard statistical methods of the multivariate analysis of the intracerebral hemorrhage (ICH) parameters in small group samples. Two different methods for data transformations (log transformation (log(Xi )), square root transformation (√Xi ))have been carried out. The initial volume of the ICH have been studied using several test for skewness, kurtosis, histogram distribution method and different quartile-quartile (Q-Q) and probability-probability (P-P) plots as criteria for normal distribution. Multivariate analyses for the prediction of the perifocal edema was performed using raw and transformed data. Our results indicate that the data transformation operations should be performed very carefully because different analytical outputs lead to different scientific conclusions.</jats:p>
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Evaluation of peripheral serotonin content and α2-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements
(Informa UK Limited, 2018-09)
Aleksovski, Boris
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Vujović, Viktorija
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We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet α2-adrenergic receptors (α2-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD).
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Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume
(Wiley, 2023-03)
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Aleksovski, Boris
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Mihajlovska Rendevska, Ana
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We aimed to analyze the inflammatory and oxidative stress (OS) markers after intracerebral hemorrhage (ICH) and their temporal changes, interaction effects, and prognostic values as biomarkers for the prediction of the edema volume. Our prospective, longitudinal study included a cohort group of 73 conservatively treated patients with ICH, without hematoma expansion or intraventricular bleeding, which were initialized with the same treatment and provided with the same in-hospital care during the disease course. Study procedures included multilevel comprehensive analyses of clinical and neuroimaging data, aligned with the exploration of 19 inflammatory and five OS markers. White blood cells (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophilia, and lymphopenia peaked 3 days post-ICH, and they showed much stronger correlations with clinical and neuroimaging variables, when compared to the admission values. An intricate interplay among inflammatory (WBC, CRP, neutrophils, neutrophil-to-lymphocyte ratio [NLR], interleukin (IL)-6, and IL-10) and OS mechanisms (catalase activity and advanced oxidation protein products [AOPP]) was detected operating 3-days post-ICH, being assessed as relevant for prediction of the edema. The overall results suggested complex pathology of formation of post-ICH edema, via: (A) Not additive, but statistically significant synergistic interactions between CRP-ESR, neutrophils-CRP, and neutrophils-IL-6 as drivers for the edema formation; (B) Significant antagonistic effect of high protein oxidation on the CRP-edema dependence, suggesting a mechanism of potential OS-CRP negative feedback loop and redox inactivation of CRP. The final multiple regression model separated the third-day variables NLR, CRP × AOPP, and WBC, as significant prognostic biomarkers for the prediction of the edema volume, with NLR being associated with the highest effect size. Our developed mathematical equation with 3D modeling for prediction and quantification of the edema volume might be beneficial for taking timely adequate strategies for prevention of delayed neurological deteriorations.
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Depression and insomnia among students during COVID-19 pandemic - cross sectional study
(National Library of Serbia, 2023)
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Aleksovski, Boris
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Bukovetz, Jansun
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<jats:p>Introduction/Objective In the first year of COVID-19 pandemic, global prevalence of anxiety and depression increased by a massive 25%, according to the World Health Organization. Objective of the study was to determine the level of depression and insomnia among students in North Macedonia during COVID-19 pandemic. Methods Cross-sectional study was performed among students at the Ss. Cyril and Methodius University in Skopje during May-July of 2021. The anonymous online survey contained questions for sex, age, their opinion, and attitude to COVID-19 infection, if they had any infection/isolation and about physical activity during the pandemic. We used scales for assessment of insomnia (Insomnia Severity Index - ISI) and depression (Patient Health Questionnaire 9 - PHQ-9). Results The study was completed by 355 participants, 28.4% of them had clinically important insomnia scores and almost 47.5% of the participants presented clinically important depression scores. Female and younger participants had higher scores for both scales. A highly statistically significant, positive correlation was detected between ISI and PHQ-9 scores (? = 0.646, p = 4.05?10-43), suggesting that during the examined cross-sectional period of COVID-19 pandemics, depression and insomnia were mutually connected. Conclusions COVID-19 pandemic caused a serious impact on mental health of the population, especially on young people, girls, students, and those who live alone. Therefore, we should be prepared for support and treatment of these vulnerable groups, not only as health care services, but also as educational institutions to give support to students in terms of consultation and motivation.</jats:p>

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