SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms

Aleksovski, Boris; Neceva, Violeta; Vujović, Viktorija; Manusheva, Nensi; Rendevski, Vladimir; Novotni, Antoni; Filipche, Ana; Spasovska, Anastazija; Sofijanova, Aspazija; Aleksovski, Vasko; Gjorgoski, Icko

doi:10.1016/j.thromres.2018.03.006

SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms

Journal

Thrombosis research

Date Issued

2018-05

Author(s)

Aleksovski, Boris

Neceva, Violeta

Vujović, Viktorija

Spasovska, Anastazija

Aleksovski, Vasko

DOI

10.1016/j.thromres.2018.03.006

Abstract

Adverse effects with bleeding disorders are often associated with the administration of SSRI in depression, although the exact mechanisms remain contradicting. This study is aimed at detecting and exploring the mechanisms of SSRI-induced changes in platelet reactivity in non-responding patients with Recurrent Depressive Disorder (RDD) and life-long exposure to antidepressants.