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    Body Composition and respiratory parameters in different age groups of football players
    (Faculty of Physical Education, Sport and Health, Skopje, Republic of Macedonia, 2022)
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    Ejupi A
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    Abstract Pulmonary function tests (PFTs) are commonly used for evaluating respiratory status in healthy subjects and for patients with pulmonary disease. They have also become a part of routine health examinations in respiratory, occupational, and sports medicine, and in public-health screening. The results of PFTs are interpreted in relation to normal range reference values, as recommended by the guidelines of the American Thoracic Society (ATS) and the European Community for Coal and Steel (ECCS). Spirometry is a gold standard of pulmonary function tests that measures the capacity of inhales and exhales volumes, more often as a function of time. It is often used in pulmonary function procedures, having become indispensable for the prevention, diagnosis, and evaluation of various respiratory impairments. A number of 61 football players were divided into 2 groups according to age: I group - below 18 years old (13.85 ± 3.26) and II group - above 18 years old (23.82 ± 3.32). This study was performed at the Institute of Medical, Experimental and Applied Physiology and Anthropology, Medical Faculty in Skopje. The spirometry method was performed with the Spirobank II spirometer (Rome, Italy), for the following parameters: forced vital capacity (FVC) in L, forced expiratory volume in the first second (FEV1) in L, and the ratio FEV1/FVC ratio (%). Body composition analyzer InBody 720, Great Britain, was used to determine body weight (kg), body height (cm), body mass index - BMI (kg/m2 ), skeletal muscle mass - SMM (kg) and the amount of proteins (kg) and minerals (kg). There was a significant difference in 2 examined groups of football players regarding all body composition parameters (p<0.001). No statistically significant difference was found for FVC, FEV1, and for the FEV1/FVC ratio. There was a difference in body composition parameters between the two age groups, without any influence on respiratory parameters. All these results may contribute to proper selection of training procedures, appropriate diet, and personalized performance. Key words: spirometry; pulmonary function; body composition.
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    BODY COMPOSITION RELATED TO BODY MASS INDEX AMONG YOUNG ELITE FOOTBALL PLAYERS
    (Medical faculty, Ss Cyril and Methodius University in Skopje, 2017)
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    Abstract Introduction. Body composition is extremely important for athletes’ performance, thus assessment tools may be used to clarify their sports condition. The aim of the study was to investigate body composition measurements and maximal oxygen consumption related to body mass index (BMI) in young elite football players. Material and methods. A total of 29 young football players were divided into 3 groups related to the value of BMI: I group (n=8); II group (n=13); and III group (n=8). The subjects were submitted to the sub-maximal pulse approach on treadmill method (SchillerAg, MTM-1500 Bear, Switzerland) to measure VO 2max (ml/kg/min). A body composition analyzer (InBody720, Biospace Co, Seoul, Korea) was used to determine the body fat - BF (%), skeletal muscle - SM (%) and total body water – TW(L) including intracellular body water – ICW(L) and extracellular body water – ECW(L). For the statistical analysis, a t-test was performed upon which the significance for p<0.05 was considered. Results. The football players showed the highest VO 2 max value in the II group (p<0.05). BF showed increased value in the III group (p<0.02). SM did not show any significant difference between the groups. Body water composition showed no statistical significance. Conclusion. Due to our results, we may conclude that certain parameters may determine the condition of young athletes in order to select appropriate training procedures, proper diet, and personalized performance. Key words: football; body mass index; body composition.
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    The resting metabolic values related to different sport disciplines
    (Faculty of Physical Education, Sport and Health, Skopje, Republic of Macedonia, 2022)
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    Abstract Athletes compared to physically inactive people have a higher percentage of muscle mass which is a result of their active lifestyle. Higher percentage of muscle mass contributes to higher value of resting metabolic rate (RMR) in athletes. The aim of this study is to compare the values of resting metabolic rate in different sports disciplines which will give us a general knowledge of the energy expenditure in different sports. A number of 79 male athletes from 4 different sports (handball, football, cycling and functional fitness) were included in this study. Bioelectrical analisator In Body 720, Great Britain was used for body composition analysis and indirect calorimeter Fit Mate, COSMED, (Italy) for resting metabolic rate. All participants completed questionnaires for their medical history and physical activity. The results showed that handball players have significantly higher values of height, weight and skeletal muscle mass compared to the other sports (p<0,05), while percentage of body fat was lowest among football players. Handball players have higher values for RMR compared to the other sports, but have statistically different values only compared to cyclists. Cyclists have significantly lower values for RMR compared to the other sports (p<0,05). Because RMR has a major impact on total daily energy expenditure (TDEE) we come to the conclusion that handball players have higher TDEE and they need a balanced nutritional regimen that will provide all required nutrients, preferably with a higher caloric rate. Key words: athletes; resting metabolic rate; energy expenditure
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    ENERGY REGULATION BY DIFFERENT MOLECULES
    (Faculty of Physical Education, Sport and Health, Skopje, Republic of Macedonia, 2022)
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    Abstract Energy homeostasis is regulated by several physiological systems such as endocrine, gastrointestinal, and nervous system, that contribute to maintaining the balance between energy expenditure and energy intake. Food intake as well as food utilization are essential components in the maintenance of energy balance. Exercise is a state that interferes with energy regulation, thus it has a good impact on healthy lifestyle and long lifespan. The aim of the study was to discover the possible role of some energy regulation molecules and their influence during exercise. A number of 37 scientific studies from PubMed, ScienceDirect, MEDLINE, and Scopus databases were examined from the period of the last 20 years, combining the physiological mechanisms relatedto energy regulation molecules. The Cochrane database was used by dividing molecules into different groups: anorexigenic / orexigenic molecules, incretins, adipokines, and myokines, all related to energy regulation and exercise induced metabolic changes. Thus, variety of molecules derived from the adipose tissue (Leptin, Adiponectin, IL-6 – Interleukin-6, TNF-α – tumor necrosis factor α), from the muscle tissue (Irisin, Myostatin), from intestine and gastric cells (YY - pancreatic peptide YY, GLP-1- Glucagon like peptide-1, GIP- Gastric inhibitory peptide, Ghrelin), from liver tissue (FGF-21- Fibroblast growth factor-21), from pancreatic cells (Amylin), and other molecules are being explored. To understand the exercise induced molecule action mechanisms and their interference, may be useful toward new pharmaceutical approaches, related to energy metabolism regulation. Key words: energy homeostasis; physiological mechanisms; exercise.
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    COMPARISONS AND CORRELATIONS OF THE ELECTROCARDIOGRAPHY CHANGES REGARDING THE FUNCTIONAL FEATURES BEFORE, DURING AND IMMEDIATELY AFTER THE TREADMILL TEST WITH ATHLETES
    (Faculty of Physical Education, Sport and Health in Skopje, 2019)
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    The need for cardiovascular screening in order to timely detect and diagnose the morphological and functional changes of the heart, which occur as a result of doing sport actively, and thus to avoid the occurrence of sudden cardiac death, is generally accepted. To achieve the objectives of the study, two noninvasive diagnostic methods for cardiovascular evaluation were used: electrocardiography (ECG) and the Bruce protocol test. The purpose of this study was to determine and examine the relationship of ECG changes to functional characteristics before, during, and/or immediately after exercise testing. This crosssectional study conducted during 2016/2017 involved 285 athletes aged 9 to 38, of both sexes. They were all given a 12-channel electrocardiogram (ECG) at rest, after which personal, family and sports history and anamnesis were given, followed by a Bruce protocol test and functional parameters were examined (symptoms, metabolic equivalents, METs, test duration, exercise capacity-VO2 max, rhythm disturbance, heart rate, heart rate reserve and recovery, chronotropic incompetence (CI), systolic and diastolic blood pressure). According to ECG changes and in accordance with international recommendations for its interpretation, athletes were divided into 4 groups: with normal, physiological, borderline or abnormal ECG findings. The results showed a significant positive connection between abnormal ECG and the occurrence of rhythm disturbance during the exercise test (r = 0.119; p = 0.045); Cardiovascular capacity expressed in (METs) compared to respondents with normal ECG was significantly higher in those with physiological ECG changes (p = 0.003), HR reserve percentage was lowest among athletes with abnormal ECG, and CI had the highest percentage. It can be concluded that an athlete with borderline, abnormal, and possibly physiologically assessed ECG should undergo further evaluation.
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    OBESITY PARAMETERS IN FEMALE MEDICAL STUDENTS
    (Faculty of Medicine, University Ss. Cyril and Methodius in Skopje, 2021)
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    Abstract Introduction.The behavioral patterns, eating habits and participation in physical activities of university students have important influence on body composition of this young population group. The aim of this study was to determine the level of overweight and obesity in female medical students and level of physical activity. Material and methods. A descriptive cross-sectional study was conducted at Faculty of Medicine, Ss. Cyril and Methodius University in Skopje between December 2019 and April 2020. A total of 308 girls, students of the 1st and 2nd year of study, underwent body composition testing with InBody 720 bioimpedance analyzer. International physical activity questionnaire (IPAQ) was used for determining the level of physical activity. Results. The average age of participants was 19.4  1.1 years, and the mean values for obesity parameters were as followed: BMI = 22.5  4.3 kg/m2 ; BF% = 28.3  8.5; WHR= 0.87  0.07. One third of students had normal body fat percentage (34.5%) and waist-to-hip ratio (33.3%). Two thirds of students showed normal BMI, and 14.6% of girls were overweight while 6% were obese according to BMI. The greatest percentage of students, 60% of girls, showed BF% and WHR higher than normal values. Conclusion. Analysis of obesity parameters derived from bioimpedance analyzer – (BIA) showed that BMI parameter was less sensitive to level of obesity than BF% and WHR. The findings revealed that more than half of the young female medical students were overweight and/or obese. Key words: obesity, body mass index, body fat, waist to hip ratio, students
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    THE SIGNIFICANCE OF THE ELECTROCARDIOGRAPHIC SCREENING USED IN PREVENTION AND DETECTION OF PATHOLOGICAL CHANGES IN HEARTS OF ATHLETES
    (Faculty of Physical Education, Sport and Health, Skopje, Republic of Macedonia, 2022)
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    Abstract Changes in the structure and function of the heart that occur as a result of engaging in professional amateur training can be detected in a timely manner by using 12-channel electrocardiography (ECG) as one of the non-invasive methods used for cardiovascular screening in athletes.. The aim of the study is to promptly detect and diagnose cardiovascular conditions that can cause sudden cardiac death in athletes. In this prospective cross-sectional study conducted during 2016/2017, 285 examinees-athletes aged 9-38 years of both sexes were included (62,1% men and 37,9% women). An ECG was performed on all of them and a personal, sports and family history was taken. According to the ECG changes and in accordance with international recommendations for its interpretation, the examinees were divided into 4 groups. The results showed that physiological changes in the ECG were found in 51,9% of examinees, borderline changes in the ECG in 21,4%, while abnormal in 7,7%. Due to the possibility of timely identification and detection of heart changes due to physical activity or congenital, and could cause sudden cardiac death, the use of 12-channel electrocardiography is necessary in the evaluation of athletes. Key words: electrocardiography, sudden cardiac death, screening for cardiovascular disease, athletes
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    Correlation of electrographic changes with sport activity characteristics and certain anthropometric characteristics in athletes.
    (Faculty of Medicine, University, Ss. Cyril and Methodius in Skopje, 2019)
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    ANTHROPOMETRICAL PARAMETERS OF OBESITY IN MACEDONIAN URBAN CHILDREN AGED 13-15 YEARS OLD
    (Medical faculty, Ss Cyril and Methodius University in Skopje, 2015)
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    MORPHOLOGICAL CHANGES OF THE HEART AS A RESULT OF VARIOUS FORMS OF PHYSICAL EXERTION
    (Anthropological Society of Serbia / Antropolos ko drus tvo Srbije, 2025)
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    Introduction. As a result of regular physical activity/physical training, i.e. long-term participation in sports, changes in the structure and function of the heart occur, more commonly known as cardiac remodeling. Materials and Methods. The sample comprised 285 athletes of both sexes between the ages of 9 to 38. Anthropometric parameters (gender, age, height, weight) were determined, a personal and sports history was taken, and a 12- lead electrocardiogram (ECG) was performed in the group of studied athletes. In 54 subjects with ECG changes, 2D transthoracic echocardiography was performed. Results. Longer duration of resistance training throughout the week was statistically significantly associated with: greater left atrial (LA) internal dimension (r = 0.359, p = 0.008), greater indexed LA volume (r = 0.315, p = 0.020), lower LA ejection fraction (r = -0.380, p = 0.005), greater left ventricular (LV) internal dimension in systole (r = 0.336, p = 0.013), greater interventricular septal and posterior wall thickness in diastole (r = 0.399; p = 0.003; r = 0.347, p = 0.010; respectively), as well as a greater indexed LV mass (r = 0.326, p = 0.016; going to the gym and lifting heavier weights was shown to be associated with: greater internal dimension of the LA (r = 0.322,p = 0.018), greater internal dimension of the right atrium (RA) (r = 0.322,p = 0.018 and greater thickness of the interventricular septum and posterior wall in diastole (r = 0.272; p = 0.004; r = 0.397,p = 0.003).