Comparative analysis of different nuclear medicine techniques in evaluation of renal function
Journal
Nuclear Medicine Revue
Date Issued
2023
Author(s)
Aleksandra Peshevska, Tanja Makazlieva, Venjamin Majstorov, Lambe Barandovski, Irena Rambabova-Bushljetik, Daniela Miladinova
DOI
10.5603/NMR.2023.0011
Abstract
Introduction: Nuclear medicine (NM) methods play an important role in the evaluation of renal function in a wide range of clinical
indications. The aim of our study was to evaluate the correlation between measured GFR (mGFR) obtained by the three-plasma
sample slope-intercept NM method (TPSM) — reference method vs. estimated GFR (eGFR) using Fleming’s single plasma
sample method (SPSM) at 120 min, 180 min, and 240 min and correlation of reference method with eGFR with camera-based
Gates’ protocol.
Material and methods: A total of 82 subjects (33 male/49 female) with a mean age of 54.87 ± 15.65 years were included and
mGFR value was obtained by the three-plasma sample slope-intercept NM method and eGFR was obtained with Fleming’s single
sample method. eGFR was also quantified with the camera-based Gates’ protocol after i.v. application of [99mTc]Tc-DTPA.
Results: Our study revealed a very strong positive significant correlation between all three SPSMs with the TPSM as the reference
method. Between the Gates’ method and the TPSM in the group of patients with mGFR ≥ 61–84 mL/min/1.73 m2 and mGFR
≥ 84 mL/min/1.73 m2, a moderate positive statistically significant correlation was obtained.
Conclusions: The SPSM method shows a very strong correlation with the reference and low bias in all three groups of patients
and can be routinely used for GFR estimation.
indications. The aim of our study was to evaluate the correlation between measured GFR (mGFR) obtained by the three-plasma
sample slope-intercept NM method (TPSM) — reference method vs. estimated GFR (eGFR) using Fleming’s single plasma
sample method (SPSM) at 120 min, 180 min, and 240 min and correlation of reference method with eGFR with camera-based
Gates’ protocol.
Material and methods: A total of 82 subjects (33 male/49 female) with a mean age of 54.87 ± 15.65 years were included and
mGFR value was obtained by the three-plasma sample slope-intercept NM method and eGFR was obtained with Fleming’s single
sample method. eGFR was also quantified with the camera-based Gates’ protocol after i.v. application of [99mTc]Tc-DTPA.
Results: Our study revealed a very strong positive significant correlation between all three SPSMs with the TPSM as the reference
method. Between the Gates’ method and the TPSM in the group of patients with mGFR ≥ 61–84 mL/min/1.73 m2 and mGFR
≥ 84 mL/min/1.73 m2, a moderate positive statistically significant correlation was obtained.
Conclusions: The SPSM method shows a very strong correlation with the reference and low bias in all three groups of patients
and can be routinely used for GFR estimation.
Subjects
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