Skeparovska, Kristina

Preferred name

Official Name

Skeparovska, Kristina

Alternative Name

Skeparovska Hristina

Kristina Skeparovska

Кристина Скепаровска

К. Скепаровска

K. Skeparovska

Skeparoska K

Skeparoska H

Скепаровска Кристина

Скепаровска К

Скепароска Кристина

Скепароска Христина

Скепароска Х

Skeparovska K

Main Affiliation

kristina.skeparovska@medf.ukim.edu.mk

Now showing 1 - 10 of 55

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INTERMEDIATE UVEITIS AS THE FIRST PRESENTATION OF MULTIPLE SCLEROSIS
(Macedonian Association of Anatomists, 2020-07-16)
Ana Trpeska
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Abstarct Intermediate uveitis is a chronic, relapsing disease of insidious onset in which according to the SUN Working Group, the vitreous is the primary site of inflammation as determined clinically. Intermediate uveitis associated with systemic disease has variable course. Multiple sclerosis is associated with intermediate uveitis. We report a case of multiple sclerosis were intermediate uveitis was the first presentation of the disease. A 33 year old man with a 5 months history of decreased vision in his right eye. Best corrected visual acuity was 0.6 on his right eye and 1.0 on his left eye. Intraocular pressure was 17 mmHg and 15 mmHg on the right and left respectively. He had no signs of ocular surface inflammation, cornea clear, AC without signs of inflammation, lens clear. Right eye 3+ vitreous cells and vitreous condensations left eye 1+vitreous cells. Right eye fundus showed hyperemia of optic nerve head, irregular reflexes in the macula, peripheral retina without signs of retinitis or vasculitis. Left eye fundus showed only optic nerve head slightly hyperaemic. OCT, Indocyanine Green Angiography and fluorescein angiography were performed. We performed the investigations for diagnosing uveitis (angiotensin converting enzyme , serology for Treponema pallidum, Borrelia burgdorferi, Mantoux, neurological investigation) and all turned out to be negative except of MRI Brain and Spine that revealed multiple T2 hyperintense lesions consistent with multiple sclerosis. Multiple sclerosis may present initially with an intermediate uveitis. Multiple sclerosis should be suspected in patients aged 20 - 50 even without any neurological symptoms, noting that intermediate uveitis may precede other symptoms of demyelination.
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OBESITY AS A RISK FACTOR FOR ENDOMETRIAL PATHOLOGICAL CHANGES
(University Ss. Cyril and Methodius in Skopje, 2023)
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Shpisikj Pushevska, Anamarija
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Ilievski, Zoran
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Eftimova Kitanova, Aleksandra
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DOUBLE, VERY SHORT CYSTIC ARTERY: ANATOMIC VARIATION REVEALED DURING LAPAROSCOPIC CHOLECYSTECTOMY: A CASE REPORT
(Македонско лекарско друштво = Macedonian Medical Association, 2020)
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Marija Toleska
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Introduction. The cystic artery (CA) is the key struc-ture sought to be clipped or ligated during laparoscopicor conventional cholecystectomy.In up to 25% of sub-jects, the superficial and deep branches of the CA have separate origins and Michels called them double CA. Case report. We are presenting a 38-year-old female with one-year history of chronic gallbladder inflamma-tion. During the laparoscopy dissection in the region of the Calot’striangle, we revealed an anatomic va-riation of the cystic artery-a double cystic artery. The more important thing was that both branches were ex-tremely short, or at the lower limit of the publishedlengths of this blood vessel-approximately 3mm each. Bydoing so, the surgicalcourse further took the standardcourse-laparoscopic clips were placed on both branches. Conclusion. The incidence of double CA ranges from 15 to 25%. Such arteries usually arise from RHA and frequently replace the deep branch of the CA. Anatomicvariations in and around Calot’s triangle are frequent. Therefore, careful dissection of Calot’s triangle is ne-cessary for both conventional and laparoscopic chole-cystectomy. Hemorrhage could be a problem during search of the CA if these variations are overlooked and that increases the rate of conversion to open surgery. It also hasto be kept in mind that during laparoscopic visualization anatomical relations are seen differently compared to conventional cholecystectomy
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HYPERTENSIVE DISORDERS IN PREGNANCY-PHYSICIANS’AWARENESS FOR EARLY DETECTION
(Македонско лекарско друштво = Macedonian Medical Association, 2019)
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Abstract Introduction. Hypertensive disorders in pregnancy are a major cause of perinatal morbidity and mortality. Early diagnosis, term delivery, and/or patient’s transfer to a tertiary institution have a huge impact on favorable outcome. Aim. To estimate ob-gyn physician’s awareness for early detection of pregnancy hypertension i.e. for establishing diagnosis before the onset of symptoms. Methods. Study population was consisted of all pregnant women in ≥37 week of gestation admitted to Special Hospital for Obstetrics and Gynecology “Mother Teresa” during the period 15.02-28.02.2018. Тhe study was designed as a retrospective one, and the data were collected by a questionnaire. Additionally, histories of all patients admitted to SHOG “Mother Teresa” between 01.01.2017 and 31.12.2017 under diagnosis of PIH/PE (pregnancy-induced hypertension/pre-eclampsia), were analyzed retrospectively whether the diagnosis was established during the hospital admission or before. Results. Twenty-two percent of pregnant women that underwent regular antenatal check-ups did not have blood pressure measurement taken by their ob-gyn physician at all. Only in 16.7% of cases, the diagnosis was established early, i.e. before the onset of symptoms. Conclusion. The awareness of ob-gyn physicians for early (pre-symptomatic) detection of hypertensive disorders in pregnancy is low.
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DEPRESSION AND ANXIETY FOLLOWING EARLY PREGNANCY LOSS – OCCURRENCE AND RISK FACTORS
(Macedonian Association of Anatomists and Morphologists, 2023)
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Ilkoski, Ana
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Biljan, Aleksandra
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Drogrishki, Marta
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Simonovska, Biljana
Early pregnancy loss is associated with various psychological symptoms shortly after the miscarriage which, in some patients, can persist a longer period of time. The main goal of our study is to establish the occurrence-rate and risk factors for development of these symptoms. Patients with early pregnancy lose, who came in hospital were enrolled in the study. The HADS (Hospital Anxiety and Depression Scale) was used to measure symptoms of depression and/or anxiety of these patients. Chi-square test was used for statistical analysis. Out of total 70 patients, 60% reported symptoms of depression and/or anxiety at some point during the study. Half of them, i.e. 54.2% display the symptoms on the day of admission to the hospital, while 9.5% of the patients demonstrated onset of symptoms of depression and/or anxiety one month after the incident. The symptoms persisted at least one month following the miscarriage, in 64.3% of the patients. Regarding the studied variables (nationality, level of education, employment and marital status as well as number of previous pregnancy loss and the number of children), none of them shows statistically significant difference for developing symptoms of depression and/or anxiety. 60% of women display symptoms of anxiety or/and depression following early pregnancy loss, majority of them immediate after the incident, so every hospital should be well-staffed by professionals and able to provide an adequate care and psychological support for these patients. The study failed to reveal any risk factor (among selected) significantly associated with development of symptoms of depression and anxiety. Hence, every woman with such diagnosis can potentially develop psychological stress, and should be monitored carefully.
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MENAGEMENT OF BUTTONHOLE RECTAL INJURY AFTER VAGINAL DELEVERY - A CASE REPORT
(Македонско лекарско друштво = Macedonian Medical Association, 2020)
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Abstract Introduction. A special form of higher degree perinealtear is a laceration of the anorectal epithelium with in-tact external anal sphincter muscle (“buttonhole tear”). This is very rare but, when not treated, carries the risk of a rectovaginalfistula. Case Report. We present a case of a nullipara, in which a spontaneous vaginal delivery of a fetus in the vertex presentation was complicated by a buttonhole rectal tear with a partial lesion of the sphincters. It was recognized on the 4thpostpartum day, and a recon-struction of the lesion with a diversing colostomy was made soon. Upon returning the colostoma, the patient at 6 months postpartum has good continence and is in a good condition. Discussion. There are very few cases reporting an isolated rectal lesion during parturition. Several factorsmay play a role in the etiology of these lesions, inclu-ding instrumentation, birth weight of more than 4 kilo-grams, midline episiotomy, persistent occipitoposterior presentation, nulliparity, tissue factors, and second sta-ge >1 hour. Obstetric anal sphincter and rectal injuriescan be missed if rectal examination is not carried out asa standard procedure prior to suturing. This can have a devastating effect on the physical and emotional well-being of women.Conclusion. Careful examination of the vagina and the rectum should be performed in all cases of perineal tears following a vaginal delivery. Buttonhole injuries, although rare, should be considered as severe traumas similar to the 4th degree lacerations and managed prom-ptlyby experienced surgeons.
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Comparison of ELISA and chemiluminescence immunoassay methods for quantification of human Placental growth factor in serum
(Croatian Society of Biologists in Health Care, 2020-06-01)
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Bashkim Ismaili
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Placental growth factor (PlGF) is crucial during placental development in early pregnancy. Several studies in pregnancies with complications such as preeclampsia or small for gestational age neonates find that PlGF levels are significantly lower in the first trimester, which implies that the concentration of PlGF could be used as an early screening biomarker for these conditions. This study aimed to compare the performance of chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) for the quantification of human PlGF in serum. This is a comparative study on 88 pregnant women in the first trimester subjected to measurement of PlGF in serum using two commercially available kits: Human PlGF Quantikine HS ELISA (R&D Systems) and PlGF CLIA (Snibe). The overall coefficient of correlation between the tests was 0.93. When the cut-off value of 40 pg/mL was applied, it dropped significantly to 0.50 towards the lower values, while remaining an excellent 0.91 in the group with higher concentrations of PlGF. While R&D Systems’s ELISA seems to have better sensitivity, it is not very convenient to use for a small number of samples. Snibe’s CLIA automated method is user-friendly, fast and powerful. Both tests show excellent performance when indicating risk-free pregnancies.
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CORRELATION BETWEEN SERUM LEVEL OF PLACENTAL GROWTH FACTOR IN FIRST TRIMESTER OF PREGNANCY AND SUBSEQUENT PREECLAMPSIA DEVELOPMENT - А PILOT STUDY
(Македонско лекарско друштво = Macedonian Medical Association, 2019)
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Abstract Introduction. Preeclampsia (PE) is one of the leading causes for maternal and perinatal morbidity and mortality. The possibility of PE development prediction is essential for adequate management of this pathology, especially in terms of undertaken measures for disease prevention. Aim. To determine whether there is a correlation between serum levels of Placental Growth Factor (PlGF) in the first trimester of pregnancy with subsequent PE development. Methods. Study population was consisted of 307 pregnant women in the first trimester of pregnancy who had visited Special Hospital for Obstetrics and Gynecology “Mother Teresa” for aneuploidy screening. During this visit, blood was taken for measuring the PlGF level. The study was prospective-observational-cohort. All pregnant women were monitored for PE development until delivery. The group of pregnant women with PE was matched with that without disease by comparing PlGF values. Results. From the initial pool, only 283 participants completed the study. Among them, 7 developed PE. The average PlGF concentration in PE+ group was 32.29 pg/ml (1.06 MoM’s), and in PE-group 45.42 pg/ml (1.58 MoM’s). The difference between the results of the women destined to develop PE in comparison with those who are not, was statistically significant (0.018 and 0.011 for pg/ml and MoM’s respectively). Conclusion. Low serum level of PlGF in the first trimester of pregnancy is correlated with subsequent PE development.
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A Case Report Of An Adult Granulosa Cell Tumor With Large Tumor Size And Massive Ascites
(Elsevier BV, 2025-02)
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Stojchevski, Saso
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Adult granulosa cell tumors (AGCTs) are rare ovarian neoplasms, constituting up to 5% of all ovarian tumors. Typically associated with an indolent clinical course, GCTs rarely present with massive ascites, which can complicate diagnosis and treatment.
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Sociodemographic Risk Factors for Gestational Diabetes Mellitus
(Македонско лекарско друштво = Macedonian medical association, 2020-11)
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Borka Kocevska

Skeparovska, Kristina

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