CORRELATION BETWEEN SERUM LEVEL OF PLACENTAL GROWTH FACTOR IN FIRST TRIMESTER OF PREGNANCY AND SUBSEQUENT PREECLAMPSIA DEVELOPMENT - А PILOT STUDY
Journal
Македонски медицински преглед = Macedonian Medical Review
Date Issued
2019
Author(s)
Abstract
Abstract
Introduction. Preeclampsia (PE) is one of the leading
causes for maternal and perinatal morbidity and mortality. The possibility of PE development prediction is
essential for adequate management of this pathology,
especially in terms of undertaken measures for disease
prevention.
Aim. To determine whether there is a correlation between serum levels of Placental Growth Factor (PlGF)
in the first trimester of pregnancy with subsequent PE
development.
Methods. Study population was consisted of 307 pregnant women in the first trimester of pregnancy who
had visited Special Hospital for Obstetrics and Gynecology “Mother Teresa” for aneuploidy screening. During
this visit, blood was taken for measuring the PlGF level. The study was prospective-observational-cohort. All
pregnant women were monitored for PE development
until delivery. The group of pregnant women with PE
was matched with that without disease by comparing
PlGF values.
Results. From the initial pool, only 283 participants
completed the study. Among them, 7 developed PE.
The average PlGF concentration in PE+ group was
32.29 pg/ml (1.06 MoM’s), and in PE-group 45.42 pg/ml
(1.58 MoM’s). The difference between the results of
the women destined to develop PE in comparison with
those who are not, was statistically significant (0.018
and 0.011 for pg/ml and MoM’s respectively).
Conclusion. Low serum level of PlGF in the first
trimester of pregnancy is correlated with subsequent
PE development.
Introduction. Preeclampsia (PE) is one of the leading
causes for maternal and perinatal morbidity and mortality. The possibility of PE development prediction is
essential for adequate management of this pathology,
especially in terms of undertaken measures for disease
prevention.
Aim. To determine whether there is a correlation between serum levels of Placental Growth Factor (PlGF)
in the first trimester of pregnancy with subsequent PE
development.
Methods. Study population was consisted of 307 pregnant women in the first trimester of pregnancy who
had visited Special Hospital for Obstetrics and Gynecology “Mother Teresa” for aneuploidy screening. During
this visit, blood was taken for measuring the PlGF level. The study was prospective-observational-cohort. All
pregnant women were monitored for PE development
until delivery. The group of pregnant women with PE
was matched with that without disease by comparing
PlGF values.
Results. From the initial pool, only 283 participants
completed the study. Among them, 7 developed PE.
The average PlGF concentration in PE+ group was
32.29 pg/ml (1.06 MoM’s), and in PE-group 45.42 pg/ml
(1.58 MoM’s). The difference between the results of
the women destined to develop PE in comparison with
those who are not, was statistically significant (0.018
and 0.011 for pg/ml and MoM’s respectively).
Conclusion. Low serum level of PlGF in the first
trimester of pregnancy is correlated with subsequent
PE development.