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    Anthocyanin composition of Vranec, Cabernet Sauvignon, Merlot and Pinot Noir grapes as indicator of their varietal differentiation
    (Springer Science and Business Media LLC, 2011-01-22)
    Dimitrovska, Maja
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    Murkovic, Michael
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    Development of Poly(L-lactic acid) Films Containing Curcuma lunga L. Extract for Active Cheese Packaging
    (MDPI AG, 2025)
    Bužarovska, Aleksandra
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    Trajkovska Petkoska, Anka
    <jats:p>Biobased packaging solutions with active functions for different food categories are a very attractive topic nowadays. This packaging provides suitable preservation of the food quality and extends the shelf life of packed items. In addition, this is a promising pathway to overcome global pollution, to protect human health, as well as to provide a better planetary wellbeing. In this work, a packaging composition based on poly(lactic acid) (PLA) with the addition of Curcuma longa L. (C) extract prepared by the solution casting method is promoted as a potential packaging option for the active food packaging of cheese. The dopant levels of the extract were performed at 0.5%, 1%, 2%, 5%, and 10%, while the neat PLA film was used as a control. The obtained results are promising. By a thermal analysis, it is shown that C-extract has a plasticizing and nucleating effect on PLA molecules, as well as improving the barrier and other film properties. Moreover, this packaging was proven as a potential antimicrobial packaging for white cheese—it enables extending the shelf life by direct contact. This is a simple way of manufacturing biobased packaging doped with natural antimicrobials that could be used for other food categories that are prone to microbiological attack.</jats:p>
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    MINIMALLY INVASIVE PLATE OSTEOSYNTHESIS OF THE DISTAL TIBIA - COMPARISON OF TWO DIFFERENT IMPLANTS
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024)
    Nastov, Nebojsha
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    Trpevski, Simon
    Minimally invasive percutaneous locking plate osteosynthesis (MIPLPO) enables widening of indication area for using locking plates in the distal tibia region. Timing of surgery, appearance of deformity on X-ray, postoperative pain and the loss of range of motion were analyzed between two groups of patients. Preliminary results showed statistically significant advantage in shortening the operative time, appearance of deformity on X-ray, as well as improving the range of motion in patients treated with MIPLPO technique. Patients treated with MIPLPO technique showed statistically significantly better results compared to those treated with MIPPO technique.
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    Lactobacillus plantarum extracellular metabolites: In vitro assessment of probiotic effects on normal and cancerogenic human cells
    (Elsevier BV, 2014-12)
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    Cencič, Avrelija
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    Winkelhausen, Eleonora
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    Langerholc, Tomaž
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    Synbiotic functional drink from Jerusalem artichoke juice fermented by probiotic Lactobacillus plantarum PCS26
    (Springer Nature, 2016-01)
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    Velickova, Elena
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    Dimitrovska, Maja
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    Langerholc, Tomaz
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    Winkelhausen, Eleonora
    A probiotic strain Lactobacillus plantarum PCS26 was used to ferment Jerusalem artichoke juice. Growth kinetics of the bacterial strain was followed during juice fermentation both in flask and in laboratory fermentor. Jerusalem artichoke showed to be an excellent source of nutrients for L. plantarum PCS26 growth. The culture grew very well reaching more than 10(10) cfu/ml in just 12 h. The pH changed from the initial 6.5 to 4.6 at the end of fermentation. The culture hydrolyzed fructooligosaccharides present in the Jerusalem artichoke juice, yielding fructose which was presumably consumed along with the malic acid as energy and carbon source. Lactic acid was the main metabolite produced in concentration of 4.6 g/L. Acetic and succinic acid were also identified. Sensory evaluation of the fermented Jerusalem artichoke juice and its mixtures with blueberry juice showed that the 50/50 % v/v mixture would be very well accepted by the consumers. Above 80 % of the panelists would buy this drink, and over 60 % were willing to pay more for it. Culture survivability in the fermented juices during storage at 4-7 °C was assayed by the Weibullian model. The product shelf-life was extended from 19.70 ± 0.50 days of pure Jerusalem artichoke juice to 35.7 ± 6.4 days of the mixture containing 30 % blueberry juice.
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    Pre-fermentative Treatment of Grape Juice and Must from Vranec Variety with a Glucose Oxidase from Aspergillus niger
    (Springer International Publishing, 2020-09-05)
    Petkova, Verica
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    Stafilov, Trajce
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    Valorization of tomato processing by-products: Predictive modeling and optimization for ultrasound-assisted lycopene extraction
    (Elsevier BV, 2024-11)
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    Stojchevski, Martin
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    Lycopene is a carotenoid highly valuable to the food, pharmaceutical, dye, and cosmetic industries, present in ripe tomatoes and other fruits with a distinctive red color. The main source of lycopene is tomato crops. This bioactive component can be successfully isolated from tomato processing waste, commonly called tomato pomace, mostly made from tomato skins, seeds, and some residual tomato tissue. The main investigative focus in this work was the application of green engineering principles in each stage of the optimized ultrasound-assisted extraction (UAE) of enzymatically treated tomato skins to obtain functional extracts rich in lycopene. The experimental plan was designed to determine the influence of studied operating parameters: enzymatic reaction time (60, 120, and 180 min), extraction time (0, 5, 10, 15, 30, 60, and 120 min), and temperature (25, 35 and 45 ℃) on lycopene yield. Process optimization was performed based on the yield of lycopene [1018, 1067, and 1120 mg/kg] achieved at optimal operating conditions. An artificial neural network (ANN) model was developed and trained for predictive modeling of the closed extraction system, with operating parameters used as input neurons and experimentally obtained values for lycopene content defined as the output neural layer. Applied ANN architecture provided a high correlation of experimental output with ANN-generated data (R=0.99914) with a model deviation error for the entire data set of RMSE=5.3 mg/kg. The k-Nearest Neighbor algorithm was introduced to predict lycopene yield using experimental key features: operating temperature, extraction time, and time of enzymatic treatment, split into training and testing sets with an 85/15 ratio. The model interpretation was conducted through the SHAP (SHapley Additive exPlanations) methodology.
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    Apple juice as a medium for fermentation by the probiotic Lactobacillus plantarum PCS 26 strain
    (Springer Nature, 2015-02-20)
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    Velickova, Elena
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    Langerholc, Tomaz
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    Winkelhausen, Eleonora
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    Correlation of trans-Lycopene Measurements by the HPLC Method with the Optothermal and Photoacoustic Signals and the Color Readings of Fresh Tomato Homogenates
    (Springer Science and Business Media LLC, 2010-03)
    Bicanic, Dane
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    Luterotti, Svjetlana
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    Marković, Ksenija
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    van Twisk, Charlotte
    The trans-lycopene content of fresh tomato homogenates was assessed by means of the laser photoacoustic spectroscopy, the laser optothermal window, micro-Raman spectroscopy, and colorimetry; none of these methods require the extraction from the product matrix prior to the analysis. The wet chemistry method (high-performance liquid chromatography) was used as the absolute quantitative method. Analytical figures of merit for all methods were compared statistically; best linear correlation was achieved for the chromaticity index a* and chroma C*.