Faculty of Medicine
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Item type:Publication, ANEMIA IN PREGNANCY AND RISK FACTORS(Македонско лекарско друштво = Macedonian medical association, 2025-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE AND IDENTIFICATION OF POTENTIAL PREDICTORS ASSOCIATED WITH GESTATIONAL DIABETES MELLITUS IM MACEDONIA(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2025-03-01); ; Ninova, AgavniIntroduction: Peripheral nerve blocks have an increasingly important role as an anesthetic technique for surgical anesthesia, postoperative analgesia, and fast discharge of patients after surgery involving the upper or lower extremities, alone or in combination with spinal or general anesthesia. Ultrasound guidance has become the most popular for performance of peripheral nerve blocks. Methods: In our retrospective study, we included all patients that were admitted in our hospital for orthopedic procedures on lower and upper extremities who received peripheral nerve block, alone or in combination with spinal or general anesthesia in the last 5 years. Ultrasound guidance was used and local anesthetic Bupivacaine 0.5%. Dexamethasone 4 mg was given intravenously as an adjuvant to peripheral nerve blocks. Results: The total number of patients included in our study was 300, the total number of performed peripheral nerve blocks was 302. 144 (48%) patients were male and 156 (52%) – female. The type of performed blocks was: 164 (54%) femoral, adductor canal blocks 22 (7.28%), 26 supraclavicular (8.60%), 77 interscalene (25.49%), 9 axillar (2.98%), 2 popliteal (0.66%), 1 iPACK and 1 TAP block (0.33%). Peripheral nerve blocks were combined with general or spinal anesthesia or performed as a sole technique for intraoperative analgesia in 17 patients (5.67%). Discussion: In our hospital we performed ultrasound guided peripheral nerve blocks last years in combination with a general, spinal anesthesia or as a sole technic for intraoperative and postoperative analgesia. Our patients were very satisfied with good postoperative pain control, and no serious complications were observed. Conclusion: Ultrasound guided peripheral nerve blocks are good choice for intraoperative anesthesia and postoperative analgesia, especially in older patients and patients with a lot of comorbidities. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation of low-energy vertebral fracture, clinical risk factors and bone densitometry in postmenopausal women(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Carotid intima media thickness is in a relation to risk factors for coronary artery disease(Geotar-Media Publishing Group, 2020-01); ; Introduction: Carotid intima-media thickness (CIMT) is a double line pattern measured from the lumen-intima to media-adventitia interface. Measuring CIMT with B-mode ultrasound can detect early arterial wall changes. We aimed to measure CIMT in manifested atherosclerotic disease and find a relation to present risk factors. Material and methods: This cross sectional study included a population of 657 patients, with documented coronary artery disease (CAD), 66,1% were men (469 pts), 33,9% were women (241 pts). The mean age of patients was 64,72 years (55,6-73,8). The measurement of CIMT (maximal and mean) was performed with B-mode ultrasound, on longitudinal view, on multiple plaque-free segments at the level of common carotid artery, on the far wall, on both sides. Multivariate regression analysis was done to estimate independent factors for CIMT, when risk factors, age, and sex included in analysis. Results: The mean value of maximal CIMT was 0,96 mm (0,52-1,4), mean value of mean CIMT was 0,88 mm (range 0,61-1,15) and mean systolic blood pressure of 133,21 mm Hg (108,03-158,39) was found. Increased CIMT was found in 75,7% of patients (502 pts). Smoking was found as an independent risk factor for increased CIMT with odds ratio (OR) 4,7 (95% CI; 0,67-5,32) and diabetes mellitus with OR 1,6 (95% CI; 0,47-2,16). Conclusion: Diabetes and smoking are independently related to increased CIMT. These are preliminary results of National survey on 657 pts with coronary artery disease. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiological and clinical features of patients with Clostridoides difficile infection(Elsevier BV, 2024-12); ; Georgievska, DajanaAIM Investigation and identification of epidemiological characteristics, risk factors and treatment regimens effectivity in reducing morbidity and mortality. BACKGROUND C.difficile remains the leading cause of health care associated diarrhea, usually as a result of irrational use of antimicrobial therapy. METHODS Retrospective descriptive study (October 2020-january2024) included all patients with clinical symptoms of Clostridoides difficile infection (CDI) admitted at our clinic. Diagnosis is based on isolation with coproculture for C.difficile, toxin confirmation with immunochromatography, small number confirmed with PCR film array. RESULTS 594 inpatients with clinical symptoms of CDI were evaluated and diagnosis was confirmed in 44. Average mean age was 58,5 (29-90)years, approximately with no differencies on sex representation. Comorbidities and previous hospitalisations were noted in two third of them, and 63% had used antimicrobial drugs, while 34% had history of corticosteroid usage and 4,5% imunosupressive therapy. Often used antibiotics cephalosporins, clindamycine, quinolones and macrolides. 68,2% had history of protein pump inhibitors usage. Culture positive were 38%, toxinA/B is confirmed with immunochromatography in 77% of patients, PCR film array confirmed C.difficile toxin A/B in the remaining patients. Treatment is carried out with oral vancomycine in 56% of patients, 15% with metronidazole and the remaining with combination of two drugs. Regarding outcomes 90% of patients were cured while 10% had fatal outcomes and CDI is not considered the main cause of death. CONCLUSION Elderly patients with antibiotic history treatment, previous healthcare exposures and comorbidities were the most affected by CDI infection. Metronidazole and vancomycine has shown good therapeutic results. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dyslipidaemia and hypertension in patients with subclinical hypothyroidism(Macedonian Academy of Sciences and Arts/De Gruyter, 2009-12); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RESULTS FROM POST - MARKETING OBSERVATIONAL STUDY FOR THE ASSESSMENT OF SAFETY OF INTRAVENOUS IBANDRONIC ACID IN POSTMENOPAUSAL WOMEN(SHMSHM - AAMD, 2020-12-23); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RISK FACTORS IN HOSPITALIZED PATIENTS WITH STROKE POSITIVE ON SARS-COV-2-INFECTION(Macedonian Association of Anatomists and Morphologists, 2023-11); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, TYPE 2 MYOCARDIAL INFARCTION(MIT University Skopje, 2023); Myocardial injury is when there is elevated cardiac troponin values at least one value above the upper reference limit (URL). Causes of elevated troponin can be sustained bradyarrhythmia, hypotension, shock, respiratory failure, anemia, tachyarrhythmia, hypertension, heart failure, defibrillator shocks, sepsis, chronic kidney disease, stroke, subarachnoid hemorrhage, pulmonary embolism, pulmonary hypertension, infiltrative disease (amyloidosis, sarcoidosis..), chemotherapeutic agents, critically ill patients, strenuous exercise, cardiac ablation, cardiomyopathy, coronary spasm, microvascular dysfunction, atherosclerotic plaque disruption with thrombosis, etc. When it is associated with myocardial ischemia it is designated as myocardial infarction (MI). Type 2 myocardial infarction occurs due to disturbed oxygen supply and/or unbalanced demand. There are no conditions that are characteristic for type 1 MI such as plaque, rupture and thrombosis - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Myopia and glaucoma - Risk assessment(Macedonian Association of Anatomists and Morphologists, 2017)Glaucoma, a leading cause of irreversible blindness among the older population worldwide, is progressive optic neuropathy. The primary objective of this study is to evaluate the connection of the myopia with glaucoma. The other purposes, which is expected to be determined during the examination are: whether a certain type to myopia, presents a greater risk factor for the occurrence of glaucoma, from the other; also , to evaluate the degree of glaucoma changes compared to the amount of the myopia. The study is case-control study, in which are involved patients aged 25-70 years, with refractive anomaly myopia. The study is carried out of the University clinic for eye diseases, in Skopje, in the Cabinet for glaucoma. We examined 20 patients with refractive anomaly myopia, of which 8 patients are diagnosed as glaucoma and 12 patients without glaucoma. In all patients were made investigations: rate pressure, visual field, gonioscopy, ultrasound and biometry, OCT. From the obtained results can be determined as following: regarding the visual sharpness (with and without correction), patients who have myopia and glaucoma have a lower visual acuity, compared to patients who have myopia. There is no significant difference compared to ocular pressure between the two groups, as a result of the therapy that patients with glaucoma use. Characteristic of the results is the examination of the thickness of retinal layer of nerve fibers. This thickness is noticed between the two groups of patients. More than half of patients with myopia without diagnosed glaucoma, have thinner RNFL, which represents one of the primary findings to diagnose the glaucoma treated. The extent of damage which causes glaucoma, depends on the time of its detection. Later diagnosed glaucoma, will cause greater suffered damages. That is the reason why they are effort to highlight the need, in all patients in whom will be diagnosed myopia, to be implemented investigations for glaucoma detection, in order to prevent timely the damages of the nerve and retina.
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