Faculty of Medicine
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Item type:Publication, Role of Cytology and Cytoblock in Diagnosis of Malignant Pleural Effusions(Македонско лекарско друштво = Macedonian medical association, 2023); ; ; Tatabitovska, AleksandraIntroduction. Pleural effusion is a common compli-cation of malignant diseases and its precise diagnosis is an important factor for staging and optimizing the treatment of a patient. The aim of this study was to de-termine the diagnostic value of cytology and cytoblock in the detection of malignant pleural effusion in patients with pulmonary and extra-pulmonary neoplasms. Methods. We conducted a cross-sectional study from January 2022 to March 2023 with retrospective approach. We included 92 patients with malignant diseases re-ferred to our Clinic of Pulmonology for diagnosis of their new-onset pleural effusion. We analyzed their medical history, pathohistology of the primary tumor and cytology results from cytospin and cytoblock pre-paration from their pleural effusions samples Results. Of the 92 included patients, positive cytology (classification group IV and V) was obtained in 31 (33.69%), negative (group I and II) in 57 (61.95%) and group III in 4 patients (4.34%). Positive cytology was obtained in 17 patients (54.83%) with pulmonary neo-plasms, 11(35.48%) with extra-pulmonary neoplasms and 3(9.67%) neoplasms with undefined etiology. Com-paration of the results from cytoblock and cytospin preparations showed that the diagnostic yield of cy-toblock was greater that cytospin preparation. The results from cytoblock were compatible with the pathohistology result from the primary neoplasm in 88.46% of patients. Conclusion. Cytology and cytoblock obtained from pleural effusion could be valid diagnostic procedures, especially in patients with advanced malignant disease who are not candidates for more invasive diagnostic procedures. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Computer system for data processing in a histopathology and cytopathology laboratory(Science Printers and Publishers, 1990-06); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation between cytopathology and histopathology in women with squamous cell abnormalities of the uterine cervix(SHMSHM / AAMD, 2017); ; ; ; Objective: The aim of the study was to correlate the results of cervical cytology and cervical biopsy in women with squamous cell abnormalities of the uterine cervix. Materials and Methods: This comparative retrospective study was conducted in a series of 184 sexually active women, aged 20 to 60, who came to their annual gynecological exam at the University Clinic for Gynecology and Obstetrics in Skopje between September 2015 and March 2016. In all 184 patients with cytologically diagnosed squamous cell abnormalities of the uterine cervix, a colposcopic cervical biopsy with endocervical curettage for histopathological analysis was taken, with was analyzed at the University Clinic for Radiotherapy and Oncology in Skopje. The results of the liquid-based cytology smears and cervical biopsies were compared to evaluate the diagnostic agreement between the cytology findings and the biopsies. Results: Cytopathologically, there were 118 (64.13%) ASC-US, 22 (11.96%) LSIL, 38 (20.65%) HSIL and 6 (3.26%) invasive carcinoma cases. Histopathologically, there were 108 (58.70%) non-neoplastic lesions, 24 (13.04%) LGSIL cases, 42 (22.83%) HGSIL cases and 10 (5.43%) invasive squamous cell carcinomas. Including all squamous cell abnormalities, the sensitivity of the smear test in low-grade and higher grade lesions was 58.70% (108/184) and the false positivity was 41.30% (76/184). Excluding ASC-US lesions, the sensitivity of the smear test was 78.80% (52/66) and the false positivity was 21.21% (14/66). After evaluating cervical cytopathological correlation the positive predictive value was found to be 100% (6/6) in invasive carcinoma, 68.42% (26/38) in HGSIL and 31.82% (7/22) in LGSIL. Conclusions: The high sensitivity of the cervical smear test for high-grade squamous lesions shows that it is an effective screening test for cervical cancer and precursor lesions.