Role of Cytology and Cytoblock in Diagnosis of Malignant Pleural Effusions
Journal
Македонски медицински преглед = Macedonian medical review
Date Issued
2023
Author(s)
Todevski, Dejan
Tatabitovska, Aleksandra
Stoshevski, Bojan
Ognenoska Jankoska, Biljana
Vince Zdraveska, Teodora
Abstract
Introduction. Pleural effusion is a common compli-cation of malignant diseases and its precise diagnosis is an important factor for staging and optimizing the treatment of a patient. The aim of this study was to de-termine the diagnostic value of cytology and cytoblock in the detection of malignant pleural effusion in patients with pulmonary and extra-pulmonary neoplasms.
Methods. We conducted a cross-sectional study from January 2022 to March 2023 with retrospective approach. We included 92 patients with malignant diseases re-ferred to our Clinic of Pulmonology for diagnosis of their new-onset pleural effusion. We analyzed their medical history, pathohistology of the primary tumor and cytology results from cytospin and cytoblock pre-paration from their pleural effusions samples
Results. Of the 92 included patients, positive cytology (classification group IV and V) was obtained in 31 (33.69%), negative (group I and II) in 57 (61.95%) and group III in 4 patients (4.34%). Positive cytology was obtained in 17 patients (54.83%) with pulmonary neo-plasms, 11(35.48%) with extra-pulmonary neoplasms and 3(9.67%) neoplasms with undefined etiology. Com-paration of the results from cytoblock and cytospin preparations showed that the diagnostic yield of cy-toblock was greater that cytospin preparation. The results from cytoblock were compatible with the pathohistology result from the primary neoplasm in 88.46% of patients.
Conclusion. Cytology and cytoblock obtained from pleural effusion could be valid diagnostic procedures, especially in patients with advanced malignant disease who are not candidates for more invasive diagnostic procedures.
Methods. We conducted a cross-sectional study from January 2022 to March 2023 with retrospective approach. We included 92 patients with malignant diseases re-ferred to our Clinic of Pulmonology for diagnosis of their new-onset pleural effusion. We analyzed their medical history, pathohistology of the primary tumor and cytology results from cytospin and cytoblock pre-paration from their pleural effusions samples
Results. Of the 92 included patients, positive cytology (classification group IV and V) was obtained in 31 (33.69%), negative (group I and II) in 57 (61.95%) and group III in 4 patients (4.34%). Positive cytology was obtained in 17 patients (54.83%) with pulmonary neo-plasms, 11(35.48%) with extra-pulmonary neoplasms and 3(9.67%) neoplasms with undefined etiology. Com-paration of the results from cytoblock and cytospin preparations showed that the diagnostic yield of cy-toblock was greater that cytospin preparation. The results from cytoblock were compatible with the pathohistology result from the primary neoplasm in 88.46% of patients.
Conclusion. Cytology and cytoblock obtained from pleural effusion could be valid diagnostic procedures, especially in patients with advanced malignant disease who are not candidates for more invasive diagnostic procedures.
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