Faculty of Medicine
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Item type:Publication, SMOKING HABIT AS A RISK FACTOR ASSOCIATED WITH OCCURRENCE OF LUNG CANCER(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024-07) ;Dimitrievska, Ljubica; ;Grivcevska, Milena ;Nehteparova, MelihaLung cancer is one of the most common causes of mortality in the world, right after cardiovascular diseases. The motivation for conducting this study was the fact that the number of newly diagnosed and death cases from lung cancer has been constantly growing, especially in the last few years. The aim of the study was to present lung cancer (LC) as a public health problem today at the global level as well as in the Republic of North Macedonia. This is an analytical case-control study. It included all patients with a confirmed diagnosis of lung cancer (LC) with histopathological analysis (examined group) and patients who have not had any history of malignancy (control group), in a period of six months. Survey data were collected using a specially designed questionnaire. The study included a total of 82 respondents in both, the examined and the control group. Regarding the habit of cigarette smoking, the largest percentage of examined respondents (56%) were current smokers, compared to the control group where the largest percentage (56%) were non-smokers. The results obtained showed that the two groups differed significantly with regards to the habit of cigarette smoking. This study confirmed the association of cigarette smoking habit and lung cancer, where several variables related to smoking were examined (age at which cigarette smoking started, number of cigarettes smoked per day, duration of smoking status, type of cigarettes). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of the causes of the neurotrauma(2004) ;Marija Toleska ;Ivica Stefanovski ;R. Todorov ;E. SpiroskaN. Toleska - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiological examination and results about the causes of neurotrauma.(2005); ;Mihajlovska Ana ;Rendevski KsenofonStoilov Milcho - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiology, Evaluation and Surgical Treatment of undescended Testis in North Macedonia in the Period from 2011 to 2020(Albanian Society for Trauma and Emergency Surgery, 2023-01-20); ; ;Kamiloski, Marjan; Coklevska Shuntov, NataliaBackground; Cryptorchidism or undescended testis (UDT) is one of the most common pediatric disorders of the male endocrine glands and the most common genital disorder identified at birth. The main reasons for treatment of cryptorchidism include increased risks of impairment of fertility potential, testicular malignancy, testis torsion, and/or associated inguinal hernia Material and Methods; The aim of this study is to show the epidemical distribution of this pathology in the republic of North Macedonia from 2011-2020 and simultaneously show the number of cases in every city of Macedonia. The number of cases (by city) is shown in Table 1. All data is provided by the archives of The Institute of Public Health, North Macedonia. Discussion: It is very important to find if there is a correlation between the number of undescended testis cases in North Macedonia to the environment, genetics, level of education, level of health care institutions, etc. Reduced hormonal levels, reduced fertility and increased risk of testicular cancer are the most common side effects of no treatment or late treatment. Conclusion; This condition of the undescended testis is very common, and the possible effects of late treatment or no treatment at all are very risky. So, we have to pay attention to the risks in order to try to provide better treatment at the right point of age.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Increased risk of brucellosis misdiagnosis in regions that lose their endemicity(Malaysian Society of Parasitology and Tropical Medicine, 2023-03-31); ;Khezzani, Bachir ;Vidinic, Ivan; Over the last decades, the epidemiology of human brucellosis globally has been subjected to significant changes, with the eradication of many existing endemic hot spots. This paper describes three cases with initial misdiagnosis of brucellosis that were managed during 2011-2017 in Republic of North Macedonia, country that until recently has been declared as endemic region. In spite of the fever, constitutional symptoms, focal disease (spondylitis, pneumonia and orchitis) and previous contact with domestic animals, brucellosis was not initially recognized, and patients were inadequately managed. Brucellosis should be part of differential diagnostic considerations in patients exposed to contacts with animals, with osteoarticular symptoms and signs, constitutional manifestations and different organ involvements in endemic regions where its incidence is diminishing. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Single-center descriptive statistical analysis of glial tumors with reference to glioblastomas(Macedonian Association of Anatomists, 2022-12); ; ; ; Gliomas are the most common primary intracranial brain neoplasms composing almost 80% of all cancerous brain tumours. Glioblastoma is the most common malignant brain tumour in the adult population and accounts in about 15% of all intracranial neoplasms. This observational analytical study gives a better overview of the current state of glial tumours in North Macedonia from 2021 to 2022 with special reference to glioblastomas. Epidemiological and statistical analysis of glial and other brain tumours in a specific time period with special reference to glioblastomas. This research is an observational statistical analysis that takes place on the Institute for Pathology in the Medical Faculty of ‘’Ss. Cyril and Methodius’’ University in Skopje using the digital data base of patients that had undergone surgery in the University Clinic of Neurosurgery and were diagnosed at the Institute of Pathology during the time period 2021-2022. In the period from 2021 and 2022, at the Institute of Pathology were diagnosed 106 (62%) glioblastomas out of which classic glioblastoma histomorphology confined 85 (80.19%) cases; 9 (8.49%) glioblastomas showed oligodendroglial component, 5 (4.72%) cases were gliosarcomas and 4 (3.77%) cases were diagnosed as giant cell glioblastomas. Three (2.83%) cases showed glioblastoma histomorphology with radionecrosis. The results of this descriptive statistical analysis show that glial tumours, especially glioblastomas as most prevalent malignant tumour type deserves greater scientific attention which beside the impact on their diagnostic complexity, will expand the knowledge of this pathology field and strongly reflect on future scientific and diagnostic work. When it comes to global statistics, we can conclude that Republic of North Macedonia follows the global trends regarding the incidence of glioblastoma associated with gender and age. Our results show that glioblastoma is more prevalent in males than females with the ratio male to female being 1.2:1, and this tumour is more prevalent in patients older than 55 years with the average age of diagnosis being 61 years. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Histological and immunohistochemichemical study of malignant lymphomas in Macedonia - Study of 222 cases(Macedonian Association of Pathology, 2013); ; ; ;Ivkovski, Ljube - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Базични демографски карактеристики на болните од инвазивен карцином на грлото на матката на територијата на Република Македонија (2000-2006 година).(Македонско лекарско друштво = Macedonian medical association, 2008) ;Tanturovski, Dragan; Вовед. Инвазивниот карцином на грлото на матката е сериозен здравствен проблем во светот. Во Македонија карциномот на грлото на матката е втора најчеста малигна неоплазма кај жените, по карциномот на дојката, со регистрирани 248 новозаболени во 2003 година што е 8,8% од сите регистрирани неоплазми во таа популација. Основната цел на оваа ретроспективна епидемиолошка студија е да се одредат базичните демографски карактеристики на пациентите со инвазивен карцином на грлото на матката. Методи. Студијата претставува ретроспективна дескриптивна епидемиолошка студија. Со неа се опфатени податоците за 1406 болни од инвазивен карцином на грлото на матката на територијата на Република Македонија во периодот 2000-2006 година. Податоците се собирани од достапната медицинска документација. Статистичката обработка се направи со софтверот Statistica ver 8.0. Резултати. Просечната годишна стапка на инциденца изнесува 22,97/100000 женско население. Просечната возраст на пациентките во серијата изнесува 48+12 години. Евидентирани се сигнификантни разлики помеѓу застапеноста на македонската и српската националност (85%) и на албанската, турската и другите националности (15%). Најзагрозени здравствени региони се регионите што спаѓаат под надлежност на ЗЗЗ Струмица и Велес, со речиси двојно поголема инциденца од просечната стапка на инциденца, а најдобра е состојбата во ЗЗЗ Охрид, Тетово и Кочани, со стапки кои се за половина пониски од просечната стапка на инциденца. Заклучок. Идентификацијата на демографските групи со зголемен ризик од ова заболување овозможува креирање на скрининг програма со која посистематски би се опфатиле истите групи. Background: Invasive cancer of the uterine cervix is a serious medical problem for a large portion of the female population around the world. In the Republic of Macedonia, the invasive cancer of the uterine cervix is the second most common neoplasm in the female population right after breast cancer with 248 newly registered cases in 2003, comprising 8.8% of all the registered neoplasms. The main objective of this retrospective epidemiological study is to determine the basic demographic characteristics of the patients with invasive cancer of the uterine cervix. Materials and methods: The study is a retrospective, descriptive epidemiological study that included 1406 patients with invasive carcinoma of the uterine cervix on the territory of the Republic of Macedonia in the period 2000-2006. The data was collected from available medical records. The collected data was then processed with appropriate Statistica ver. 8.0. Results: The average yearly incidence rate is 22.97/100000. The average age for the women in the series is 4812. There are notable statistically significant differences in the representation of the Macedonian and Serbian nationalities (85%) and the Albanian, Turkish and other nationalities (15%). The regions with the highest risk are Strumica and Veles, with incidence rates almost double the average, and the regions with the least risk are Ohrid, Tetovo and Kochani with incidence rates nearly half the average. Conclusions: The identification and recognition of the demographic groups with an increased risk of developing invasive cervical carcinoma enables the creation of a screening program that would include these groups with increased risk. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Harmonized definition of occupational burnout: A systematic review, semantic analysis, and Delphi consensus in 29 countries(Scandinavian Journal of Work, Environment and Health, 2020-12-01) ;Guseva Canu, Irina ;Marca, Sandy Carla ;Dell'Oro, Francesca ;Balázs, ÁdámBergamaschi, EnricoObjective A consensual definition of occupational burnout is currently lacking. We aimed to harmonize the definition of occupational burnout as a health outcome in medical research and reach a consensus on this definition within the Network on the Coordination and Harmonisation of European Occupational Cohorts (OMEGA-NET). Methods First, we performed a systematic review in MEDLINE, PsycINFO and Embase (January 1990 to August 2018) and a semantic analysis of the available definitions. We used the definitions of burnout and burnout-related concepts from the Systematized Nomenclature of Medicine Clinical Terms (SNOMED-CT) to formulate a consistent harmonized definition of the concept. Second, we sought to obtain the Delphi consensus on the proposed definition. Results We identified 88 unique definitions of burnout and assigned each of them to 1 of the 11 original definitions. The semantic analysis yielded a first proposal, further reformulated according to SNOMED-CT and the panelists` comments as follows: "In a worker, occupational burnout or occupational physical AND emotional exhaustion state is an exhaustion due to prolonged exposure to work-related problems". A panel of 50 experts (researchers and healthcare professionals with an interest for occupational burnout) reached consensus on this proposal at the second round of the Delphi, with 82% of experts agreeing on it. Conclusion This study resulted in a harmonized definition of occupational burnout approved by experts from 29 countries within OMEGA-NET. Future research should address the reproducibility of the Delphi consensus in a larger panel of experts, representing more countries, and examine the practicability of the definition. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Translation of questions: the International Study of Asthma and Allergies in Childhood (ISAAC) experience(International Union Against Tuberculosis and Lung Disease, 2009-09) ;Ellwood, P ;Williams, H ;Aït-Khaled, N ;Björkstén, BRobertson, COBJECTIVE: To explore the consequences of translating the International Study of Asthma and Allergies in Childhood (ISAAC) English core questionnaires on asthma, rhinitis and eczema symptoms into other languages. DESIGN: ISAAC Phase III developed 49 language translations for adolescents and 42 for children following standardised guidelines, which included back-translating the questionnaires into English to check their accuracy and meaning. Language deviations were categorised and analysed with regard to infl uences on the reported symptom prevalence. RESULTS: Category 1 deviations for one or more questions were found in seven translations (14%) for adolescents and in three translations (7%) for children. Data for these questions were excluded from the worldwide analyses. Category 2 deviations were identifi ed in the publications, and Category 3 deviations were ignored. CONCLUSIONS: Translations of questionnaires should follow a consistent protocol in global epidemiological research. Cultural norms need to be considered when evaluating back-translations into English, as disease labels are not available in every language, nor are they understood in the same way. Deviations from literal translations of English should be permitted if the intent of the original meaning is retained. A web-based tool of medical terminology would be useful for international research requiring the use of translations.
