Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
6 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Ново дијагостицирана атријална фибрилација кај пациентка со активен карцином на дојка: тераписки предизвик - приказ на случај(2023-10)Breast cancer is the most common malignant disease in females. The specific cancer treatment protocol involves drugs with known cardiovascular toxicity. Patients with significant risk of cancer therapy-related cardiovascular toxicity (CRT-CVT) should be reported for cardiology referral. CASE REPORT: Seventy-year-old, obese patient with a previous history of hypertension and low normal left ventricular ejection fraction (LVEF) was diagnosed with breast cancer and scheduled for baseline assessment before initiating cardiotoxic cancer treatment protocol. Regular monitoring for an already high-risk patient for CRT-CVT was not enough for developing of first diagnosed, paroxysmal, asymptomatic atrial fibrilation after completing the 4 th cycle of anthracyclines and total cumulative dose of 208.3mg/m2. Transthoracic echocardiography did not reveal significant changes in LVEF and global longitudinal strain, so cancer therapy-related cardiac dysfunction was not the related diagnosis. Laboratory measurements of cardiac biomarkers did not confirm subclinical cardiac injury. Besides ACEinhibitors already prescribed for hypertension, drugs for rate control and anticoagulation therapy with both low-molecular-weight heparin and NOAC was the preferred therapeutic decision for successful completion of the oncological treatment. After a week, the electrocardiogram showed sinus rhythm. The patient also completed left-sided radiotherapy with total tumor dose of 41,25Gy, and six months after has stabile cardiac performances and normal sinus rhythm. CONCLUSION: CRT-CVT is the second leading cause of death in breast cancer patients. Management of the adverse effects is challenging and complex due to the imperative of completing the cancer therapy and frequent drug-drug interactions. Early detection, multidisciplinary approach and close monitoring are the cornerstone for overall good outcome in these patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SARS-COV-2 INFECTION: CARDIAL AND MULTI-ORGAN INVOLVEMENT(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2022-12); SARS-COV-2 is a single-strain RNA virus that attacks primarily the respiratory system. The second most commonly affected system is the cardiovascular. Often it attacks multiple organ systems causing multi-organ failure. Atrial fibrillation (AF) is the most common sustained supraventricular arrhythmia in acute settings of COVID-19 infection and is associated to more complications and mortality rates. The presence of AF in patients with COVID-19 pneumonia should be managed with increased attention to prevent adverse outcomes. COVID-19 may be a cause of multiple organ damage in some infected patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Atrial fibrillation and risk for ischemic stroke(League against epilepsy of Macedonia, 2017); ; Cheperganova Changovska, TatjanaAbstract Objective: To investigate the frequency of atrial fibrillation in patients who develope acute ischemic stroke, associated risk factors and their outcome. Material and methods: A retrospective study was conducted at the University Clinic of Neurology Clinic, Department for Urgent Neurology.We analyzed medical records of acute ischemic stroke patients hospitalized between April 2014 and April 2016. Statistical analysis was performed with the programme Statistica for Windows 12. Results: Of the 1102 patients in the study,219 (19.8%) had atrial fibrillation. Of them, 109 (49,8%) were males and 110 (50,2%) were females. The mean age of those patients was 65±14 years compared to 60±16 years for the rest. Patients with AF had higher modified Rankin Scale(mRS) score on admission and at discharge from the hospital and had lethal outcome in higher percentage, compared to the rest (p<0.05). Conclusion: AF significantly increases the risk of stroke and affects its prognosis and outcome. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Generation X- Challenges in anticoagulation(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2022-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Arrhythmias induced cardiomyopathy - reversible dilated cardiomyopathy in patients with atrial fibrillation/flutter with fast ventricular rate(Macedonian Society of Cardiology, 2014); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Novel anticoagulants in atrial fibrillation: focused update(European Society of Cardiology, 2013-07-15)Novel oral anticoagulants are safer than Vitamin K antagonists (warfarin) in respect to the occurrence of bleeding, especially in terms of intracranial hemorrhage. Furthermore they are non-inferior and to a certain degree are superior in comparison to warfarin, when it comes to the prevention of ischemic stroke in patients with atrial fibrillation (AF).