Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
33 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, PRIMARY SINONASAL MENINGIOMA MIMICKING BENIGN NASAL LESIONS - A CASE REPORT AND LITERATURE REVIEW(Macedonian Association of Pathology and North Macedonia Division of IAP, 2025); ; ; Jovcheva, AIntroduction: Primary extracranial meningiomas are rare neoplasms, accounting for less than 2% of all meningiomas. The sinonasal tract represents an uncommon site of origin and frequently presents diagnostic challenges due to nonspecific clinical and radiological features. Case Presentation: A 79-year-old male presented with a unilateral nasal cavity mass. Computed tomography revealed diffuse polypoid mucosal thickening with near-complete opacification of paranasal sinuses and obliteration of aeration. Histopathology showed a circumscribed neoplastic proliferation arranged in lobular and whorled patterns beneath intact respiratory epithelium. Tumor cells displayed uniform morphology with oval nuclei, eosinophilic cytoplasm, and inconspicuous nucleoli. Psammoma bodies and delicate vascular channels were present. Necrosis, nuclear atypia, and mitotic activity were absent. Immunohistochemistry showed strong positivity for epithelial membrane antigen (EMA), vimentin, p63, and progesterone receptor, while cytokeratin AE1/AE3, CD34, smooth muscle actin (SMA), S100, SOX10, desmin, and synaptophysin were negative. The proliferative index (Ki-67) was <5%. Discussion: Extracranial meningiomas are rare neoplasms with poorly understood histogenesis, presumably arising from displaced meningothelial cells during embryonic development. Sinonasal meningiomas may mimic other nasal masses including nasal polyps, inverted papilloma, olfactory neuroblastoma, or carcinoma. In this case, the morphological features combined with the supportive immunohistochemical profile confirmed the diagnosis of WHO Grade I meningothelial meningioma with angiomatous features. Conclusion: Primary sinonasal meningioma should be included in the differential diagnosis of sinonasal masses. Accurate recognition through comprehensive histopathological and immunohistochemical analysis is essential for proper diagnosis and management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gallbladder and gastric metastasis as initial presentation of an undiagnosed primary lobular breast carcinoma(Oxford University Press (OUP), 2026-02-24); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gastric schwannoma: a case report(Oxford University Press, 2024-03-27); ; ; ; Kostovska, IrenaGastric schwannomas are rare mesenchymal tumors that arise from the intestinal nerve plexuses. They present with nonspecific symptoms and are often discovered incidentally. We present the case of a 68-year-old patient who had been suffering from abdominal discomfort for 6 months. After a complete examination, including abdominal computed tomography and upper gastrointestinal endoscopy, we discovered a submucosal gastric lesion with benign gross features without evidence of lymph node or metastatic involvement. He underwent an open laparotomy. Final pathohistological and immunohistochemically identification of the surgical specimen established the diagnosis of benign schwannoma. Considering the excellent prognosis of the tumor, no adjuvant treatment was suggested other than simple clinical monitoring every 6 months. Despite the accessibility of advanced endoscopy and imaging techniques, the diagnosis of gastric schwannoma is rarely made preoperatively. In the latter case, the best treatment is still complete excision with wide margins. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Immunohistochemical expression of CD44 in patients with hepatocellular carcinoma(Macedonian Association of Anatomists and Morphologists, 2020); ; ; ; Nikolovska Trpchevska, EmilijaIntroduction: CD44, a transmembrane glycoprotein with a role in cell-cell and cell-matrix interactions and one of the stem cell markers, is considered to participate in progression and prognosis of hepatocellular carcinoma (HCC), which makes it a potential prognostic marker and therapeutic target. We aimed to evaluate immunoexpression of CD44 in tumor and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathological data in order to determine its prognostic value in patients from the Republic of North Macedonia. Material and Methods: Presence of the immunosignal and the percentage of CD44+ tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined. The immunohistochemistry results were correlated to B and C hepatitis, tumor dimensions, enlarged lymph nodes, T status, differentiation (G), microvascular invasion, and survival. Results: We found a significant difference in CD44 expression between tumor and non-tumor liver tissue (p < 0.000) and significantly higher CD44 expression was also found in T4 tumors in comparison with T1 tumors (p < 0.01). Conclusion: Expression of CD44 was significantly higher in tumor in comparison to non-tumor tissue and was significantly associated to T4 local tumor growth, making it a potential prognostic marker and therapeutic target. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VISUALISATION OF MICROGLIA WITH THE USE OF IMMUNOHISTOCHEMICAL DOUBLE STAINING METHOD FOR CD-68 AND Iba-1 OF CEREBRAL TISSUE SAMPLES IN CASES OF BRAIN CONTUSIONS(Macedonian Academy of Sciences and Arts, 2015-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Uterine adenomyolipoma. A case report and review of the literature(Wiley-Blackwell, 2010-10)Introduction. Uterine adenomyolipoma also termed adenolipoleiomyoma or lipoadenofibroma is a rare benign, polypoid or less frequently intramural lesion, considered to be of hamartomatous origin or represent an unusual type of benign Müllerian mixed tumour with a heterologous element. We report another case of this uncommon lesion and review the previously documented similar cases. Case Report. A polypoid endometrial mass measuring 28x8x5 mm was removed during explorative curettage from a 56-year old woman presented with postmenopausal vaginal bleeding. Histologically, it was composed of tubular and cystic glands within a background of connective tissue containing endometrial stroma, smooth muscle and mature adipose tissue. Many glands were of endometrial proliferative type, while elsewhere glands were of tubal type with cilia or occasionally of endocervical type. Neither the epithelial nor the mesenchymal elements showed any cytological atypia, necrosis or mitotic figures. Periglandular stromal condensation was also absent. The glandular epithelial cells were immunoreactive for cytokeratin, epithelial membrane antigen and vimentin, but negative for carcinoembryonic antigen. The endometrial stromal cells were CD10 positive; smooth muscle cells were desmin and alpha-smooth muscle actin positive, while adipocytes were S100 protein positive. The nuclei of most of the glandular cells and some of the endometrial stromal and smooth muscle cells were both ER and PR positive. The proliferation index (Ki-67) was less than 1%. Conclusion. After extensive literature search, the case presented in this article appears to be the ninth report of this unusual uterine lesion occurring most frequently in postmenopausal women and the seventh presenting as an endometrial polypoid mass. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation between PD-L1 expression and clinicopathological characteristics in triple-negative breast cancer patients(Springer, 2020-12); Ognenoska-Jankovska, BiljanaBackground & objectives: While immunotherapy is emerging as an effective treatment option for advanced triple-negative breast carcinoma (TNBC) patients, the clinicopathological significance of PD-L1 expression in TNBC remains unclear. Our objective was to investigate the association between PD-L1 expression and clinicopathological characteristics in TNBC. Methods: The study group comprised 47 TNBC patients in which PD-L1 status was evaluated by immunohistochemistry with SP142 assay on the Ventana BenchMark. All PDL1(+) tumour-associated immune cells (IC) were quantified as % of the tumour area. Tumours were classified as PDL1(+)(>=1%) or PD-L1(-)(<1%). The statistical significance of the correlation between PD-L1 status and clinicopathological characteristics was determined by chi-square test. Results: PD-L1(+) were 24(51.1%) of the 47 TNBC patients whose median age at diagnosis was 59 (range, 39-79). 53.5% (23/43) of the primary and 25%(1/4) of the metastatic TNBC cases were PD-L1(+). 21(87.5%) of the PD-L1(+) TNBC had IC1( 1 and <5%), 2(8.3%) had IC2( 5 and <10%), and 1(4.2%) had IC3( 10) score. The PD-L1(+) status significantly associated with high histological grade (G3, P=0.022), and higher proliferative index (Ki-67>35%, P=0.004), while the correlation with larger tumour size (>2 cm, P=0.055) did not reach statistical significance. No significant relationship was found between PD-L1 status and other variables such as patients` age, postoperative stage, tumour status, lymph nodal status, tumour type, vascular invasion, and p53 expression. Conclusion: Our preliminary results suggest that PD-L1 expression is associated with several high-risk clinicopathological parameters in TNBC patients. Further larger studies are warranted to clarify the clinical relevance of PD-L1 expression in TNBC patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinicopathological analysis of incidentally detected blue nevi of the uterine cervix in biopsy and curettage specimens. A report of 7 cases.(Springer, 2019-09); Ognenoska-Jankovska, BiljanaBackground & Objectives: Blue nevi (BN) of the uterine cervix (UC) are rare incidental lesions; they are often found in hysterectomy specimens from middle-aged women, or rarely in specimens obtained during more conservative diagnostic procedures (e.g. biopsy, curettage). The objective of our study was to analyse the clinicopathological features of 7 incidentally detected cases of the BN of the UC in biopsy or curettage specimens. Methods: Among a total of 60 BN of the UC diagnosed on operative and biopsy specimens in our Department between 2000-2019, in 7 (7/60, 11.7%) cases BN were found in biopsy or curettage specimens that had been taken for an examination of a clinically or cytologically suspicious cervical lesion (3/7, 42.9%) or a dysfunctional uterine bleeding (4/7, 57.1%), respectively. The mean age of the patients was 44 years (range, 29-57 years). In addition to routine hematoxylin&eosin, histochemical and immunohistochemical stainings were also performed. Results: Histologically, all cases showed loose aggregates of pigmented, spindle-shaped, dendritic or nevoid, epithelioid cells in the superficial stroma in one (4/7, 57.1%) or >2 fragments of cervical mucosa (3/7, 42.9%). The lesions ranged in size from 0.5 to 6mm (mean, 2.4mm), while their thickness ranged between 0.5-4mm (mean, 1.5mm). In one case the BN was presenting as an endocervical polyp. The pigmented cells in all tested cases were positive for melanin (Fontana-Masson), S100, Melan-A, as well as for HMB45 in 3 cases. Conclusion: Although the BN of the UC seem to be lesions of low clinical significance, they require careful differential diagnosis with other pigmented lesions including malignant melanoma, especially because they are rarely detected and might easily be missed or misinterpreted in scanty endocervical curettage or cervical biopsy specimens due to their small size, more frequent endocervical localization and occasional discrete findings. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Benign granular cell tumor of the uterine corpus: A case report(The Arab Division of the International Academy of Pathology In Collaboration with the Jordanian Society of Pathologists, 2018-10); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Multifocal Hurthle cell (oxyphilic) variant of papillary thyroid carcinoma associated with Hashimoto`s thyroiditis: A case report(Macedonian Association of Pathology, 2016-09);