Faculty of Medicine

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Author: search.filters.author.Hasan Taner

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    PLUCNA EMBOLIJA U BOLESNIKA S LEIDENOVOM TROMBOFILIJOM FAKTORA V I PSORIJAZOL: PRIKAZ SLUCAJ.
    (Association of pulmologists from Republika Srpska, 2023-05)
    Baloski Marjan
    ;
    ;
    Bushev Jane
    ;
    Brishkoska-Boshkovski Vesna
    ;
    Hasan Taner
    Cilj: Genetski faktori rizika pove!avaju rizik venske tromboembolije. Poremecaji u sintezi ili aktivnosti faktora koagulacije. Faktor V Leiden, protrombin (20210-A), antitrombinski deficit, deficit proteina C i proteina S i hiperhomocisteinemija najcesce su mutacije gena povezanih sa venskim tromboembolijom . Uvod : Psorijaza i prisutvo mutacije trombofilnih gena povecava rizik venske tromboembolije. Prethodna venska tromboembolija je jedan od najjacih faktora rizika, cak i kod pacijenata koji su aktivno leceni antikoagulansom. Psorijaza je kompleksna imuno posredovana bolest, povezana sa kardiovaskularnim rizikom, markerima hiperkoagulabilnosti i povisenim homocisteinom. Mnogo izvjestaja o opservacijama sugerira povecanu ucestalost venskih trombembolickih dogadaja kod pacijenata sa psorijazom. Nalazi: Prikazujemo bolesnika s nasljednom trombofilijom i kronicnom difuznom psorijazom kompliciranom plu!nom embolijom. Analiza DNK ukazuje na prisutnost homozigoze za mutaciju faktora V Leidena. Dermatoloska anamneza je pozitivna na psorijazu. Zaklju!ak: Prikaz ovog slucaja ukazuje na povezanost venske tromboembolije i psorijaze. Pacijenti sa naslednom trombofilijom, psorijazom I plucnim tromboembolizmom, imaju visoki rizik od razvoj venske tromboembolije.
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    Type 2 diabetes in young adults, can we do more for them? – case presentation
    (De Gruyter Open Ltd., 2021-01-19)
    Trajkovska Ivana
    ;
    ;
    Hasan Taner
    Type 2 diabetes mellitus (T2DM), once considered a disease of old age, now occurs not uncommonly in children and young adults. Youth-onset type 2 diabetes is on the rise, and trends in childhood obesity only partially explain the recent appearance of a condi-tion that was previously confined to adults. The difficulty in T2DM in young adults highlights the critical need to promote healthy lifestyle to prevent or postpone the development of T2DM in those at risk. For individuals with early onset T2DM, glycemic con-trol must be carefully monitored and treated. We reported here a case that provides a successful management and treatment of the use of metformin, liraglutide, and most important lifestyle modifications to reduce body weight in young obese patient with poorly controlled and new diagnosed T2DM.
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    ПОВРЗАНОСТ НА ПОЛИМОРФИЗМОТ C677T ВО ГЕНОТ MTHFR СО БЕЛОДРОБНАТА ЕМБОЛИЈА
    (SHMSHM - AAMD, 2020-04)
    Baloski Marjan
    ;
    ;
    Hasan Taner
    ;
    Nedeska Minova Natasha
    ;
    Petkovikj Natasha
    Белодробната емболија е релативно чест клинички ентитет проследен е со висок морталитет, па претставува дијагностички и тераписки предизвик. Досегашните студии укажуваат на постоење на генетска поврзаност на определени тромбофилии со појавата на белодробна емболија ,вклучувајќи ги полиморфизмите во генот за метилен-тетрахидрофолатредуктазата (MTHFR). Генетските анализи покажаа дека постои статистички сигнификантна поврзаност на хомозиготниот генотип ТТ, односно на алелот Т, со белодробната емболија. Носителите на овој генотип, односно алел, имаат 4,4 пати, односно, приближно 2,5 пати, соодветно, повисока веројатност од белодробна емболија во однос на носителите на хомозиготниот генотип CC или хетерозиготниот CT, односно на алелот C. Ваквите резултати се конкордантни со дел од објавените клиничко-генетски студии со сличен дизајн и укажуваат на потенцијалната употребливост на овој генски маркер во предикцијата на ризикот од белодробна емболија и текот на болеста.
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    DESCRIPTIVE ANALYSIS OF CLINICAL AND DEMOGRAPHIC DATA OF SELECTED GROUP OF PATIENTS WITH PULMONARY EMBOLISM
    (Macedonian Association of Anatomists and Morphologists, 2020)
    Baloski Marjan
    ;
    ;
    Hasan Taner
    ;
    Nedeska Minova Natasa
    ;
    Pulmonary embolism is a relatively common clinical entity accompanied with a high mortality and is a perplexing diagnostic and therapeutic problem. Current research indicates that pulmonary embolism has a multifactorial and complex pathogenesis. Genetic factors have been under extensive research during the past two decades. The aim of this study was to present a descriptive analysis of demographic and clinical data obtained thus far from 31 patients with documented pulmonary embolism. In our patient group, almost half of the patients were non-smokers and all denied alcohol consumption. More than 80% of the patients had no history of previous pulmonary embolism and no thrombophlebitis, but nearly two thirds of all patients had deep vein thrombosis. A history of acute myocardial infarction existed in about 6.5% of patients, as well as ischemic stroke. Arterial hypertension was present in about one-third of patients, dyslipidemia in 42%, and type 2 diabetes in approximately 13%. Only one patient had an anamnestic data for chronic renal disease, while none had a history of hepatic disease. The results of the analysis of demographic-clinical data of patients are concordant with the results of the previously published studies.