Faculty of Medicine
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Item type:Publication, Challenges in interpretation of forensic toxicological findings for opiates: case report and a literature review(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2016); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Retrospective study of intoxication-related deaths in Republic of North Macedonia, 2010-2020(Macedonian Pharmaceutical Association, 2022); ; Chakar, Ljupco - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VISUALISATION OF MICROGLIA WITH THE USE OF IMMUNOHISTOCHEMICAL DOUBLE STAINING METHOD FOR CD-68 AND Iba-1 OF CEREBRAL TISSUE SAMPLES IN CASES OF BRAIN CONTUSIONS(Macedonian Academy of Sciences and Arts, 2015-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ETIOLOGY OF SUDDEN CARDIAC DEATH IN FORENSIC MEDICAL PRACTICE AND SELECTION OF CASES FOR POST-MORTEM GENETIC TESTING –5 YEAR RETROSPECTIVE STUDY(Macedonian Association of Anatomists, 2023-05-10); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Suicidal injuries from height falls(Macedonian Association of Anatomists, 2022-12-29); ; ; ; According to the manner of death, falls from height can be accidental, homicidal and predominantly suicidal. The type of injuries in suicidal falls from height depend to a large extent on the height of the fall, the part of the body that landed and suffered the first impact, the age and the body weight of the victim, clothes worn and body composition. Although with prospect, the research is an average study of the Institute for Forensic Medicine in Skopje, conducted on 80 victims of fatal falls from different heights, through forensic-medical autopsy. The data for all examined cases have been taken from the forensic-medical autopsy reports. The study analyses the cases which appear to be suicides, according to the manner of death. The injuries inflicted from the falls are analysed according to the height in three groups: small height up to 7 meters, middle height from 7 to 10 meters and big heights above 20 meters. Study results have shown that 25% of the analysed cases are suicides. The analysis of the number and severity of the injuries in relation to the height of the fall prove that the fractures of the hipbone and legs were most frequent injuries found in the victims who have fallen from 7 to 20 meters. In the victims of height falls up to 7 meters, most frequent injuries were the fractures of the ribs and the spine. In falls from height above 20 meters, all organs were equally damaged. In suicides from falls from height, most frequent injuries of the skeleton were fractures of the ribs and spine, while the liver was the most affected organ among the internal organs. However, the type of injuries determined with the autopsy is not a sufficient indicator for successful assessment of the manner of death in fatal falls from height. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Forensic aspect of cerebral contusions(Macedonian medical association/De Gruyter, 2014-08); ; ; Introduction. Contusions are injuries of the brain dominantly incurred by blunt-force trauma in the head (blow, impact, fall). Proper analysis of the cerebral contusions within all head injuries and data case gives us complete view of the event and enables us to choose the right direction in the investigation. The aim of this investigation was to perform a forensic medical analysis of cases with brain injury (cerebral contusions) incurred by blunt-force trauma, and to compare results with a prior extensive research done at the Institute of Forensic Medicine, Skopje. Methods. A total of 76 cases with cerebral contusions incurred by blunt-force trauma were included. The following data were analyzed: gender, age, event, skull fractures, type of fracture, localisation of contusions and toxicological analysis. The basic descriptive processing included the above information-variables taken from the written reports of the performed autopsies. The data are displayed graphically with the use of Microsoft Excel 2007. Results. Male was the dominant gender in the analyzed cases (86%), with mean age of 51 years. Traffic accidents were the main factor for these injuries (76%). Skull fractures were found in 67% of cases. The dominant cerebral lobes were the temporal and the frontal lobe, and the contrecoup contusions were found in 55% of cases. Conclusions. The experience gained during the processing and analysis of these brain injuries answers the most complicated questions, and contributes to the healthcare especially in dealing with the diagnosis and treatment of cerebral contusions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DNA EXTRACTION FROMPOST-MORTEM SAMPLES WITH DIFFERENT DEGREES OF DEGRADATION AND THEIR SUITABILITY FOR ION S5™NEXT-GENERATION SEQUENCING SYSTEM(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023-06-16); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Fall from height injuries(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2022-12-20); ; ; ; The type of injuries sustained from fall from heights depends primarily on the fall height, the part of the body that suffered the first impact when hit the ground-primary contact, the age and weight of the victim’s body, clothes worn and the body composition. This study encompassed 60 casualties - bodies of victims of fatal falls from height, divided in three groups: fall from less than 7 meters (m), from 7 to 25 m, more than 25 m. The study analysed brain injuries, thoracic and abdominal organs, skull fractures, limb fractures, ribs and spine, as well as fractures of scapular and clavicular bones (analysed jointly). The study was focused on determining the frequency of the occurrence of different injuries, analysed one with other, that correlation depending on the height of the fall. The analysis on the number and severity of the injuries in correlation to the height of the fall showed that fractures of the hipbone and limbs were mostly present in the victims who had fallen from 7 to 25 m height. In the victims who had fallen from 7 m height, the most common injuries were fractures of the ribs and spine. In falls from height above 25 m, all organs were equally damaged. In all analysed cases, the most frequent cause of death was trauma shock, followed by cerebral contusion. Our data have shown that assessing only the pathological characteristics is not sufficient to determine the cause of death in fatal falls from heights. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A new method to determine wound age in human skin injuries(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023-06-16); ; ; ; Chakar, LjupcoWound age determination is a significant part of everyday practice in forensic medicine. Determining the wound age answers a large number of questions arising from a criminal-legal event. The RT-PCR technique enables qualitative and quantitative analysis of mRNA and can register minimal changes in gene expression, which makes it more sensitive and accurate compared to the immunohistochemical method. The study included 51 wound samples of autopsy cases. In this study we conducted comparative analyses for different methods of homogenization and isolation. An analysis was carried out for the selection of a suitable reference gene that will be used for normalization of the expression levels of the investigated target gene. Two reference genes, GAPDH and 18S, were analyzed in the study. A biphasic expression of IL-6 information RNA (mRNA IL-6) was determined in relation to the other groups, including the control group. 18S has better efficiency of amplification then GAPDH. RNA was isolated from all examined tissues with the TriXact kit on the MagCore Plus II instrument. It can also be concluded that mechanical maceration of the tissue was more effective than the other methods of homogenization. 18S is a more stable reference gene for the analysis of skin samples. IL-6 can could be used as a marker in wound age determination.