Faculty of Medicine

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Author: search.filters.author.Aleksovski, VaskoLanguage: search.filters.language.English

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    VITAMIN D STATUS AMONG PREGNANT WOMEN OF NORTH MACEDONIA:ASSESSING DEFICIENCY RATES AND ASSOCIATED RISKS FACTORS
    (Walter de Gruyter, 2025-04-16)
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    Aleksovski, Vasko
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    Gjorgievska Nikolovska, Elena
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    Objective. Vitamin D is an essential vitamin that plays a key role in maintaining overall health. During pregnancy, the demand for vitamin D increases to support the growing needs of the fetus. Vitamin D deficiency is highly prevalent in pregnant women worldwide. The aim of our study was to evaluate the vitamin D deficiency rate among pregnant women in the Republic of North Macedonia, along with influencing factors. Materials and Methods: We conducted a prospective study of randomly selected pregnant women with different body mass index and in two different seasons among vitamin supplementation users and non-users. Results: A total of 309 pregnant women aged > 18 years were recruited from August 2022 to January 2023, with an average vitamin D concentration of 38.9 (36.6-40.2) nmol/l. During the winter period, 80.8 % of pregnant women had vitamin D deficiency. Conclusion: Despite the fact that more than 77.3 % of pregnant women consume multivitamins containing vitamin D, vitamin D deficiency is highly prevalent among pregnant women especially among obese pregnant woman and during the winter months.
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    BEYOND SEIZURES: BONE MINERAL DISORDERS IN CHRONIC EPILEPSY-A CROSSSECTIONAL STUDY
    (Macedonian Neurological Society, 2025-10)
    Babunovska, Marija
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    Boshkovski, Bojan
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    Kostovska, Irena
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    The role of TNF-α-based models in prognostication of the outcomes after ICH: a pilot study
    (2019-10)
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    Aleksovski, Boris
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    Abstract Introduction: Recently, we have developed TNF-α-based models for prognostication of the 3-month neurological outcome in patients after Intracerebral hemorrhage, ICH (Rendevski et al., 2018). In this pilot study, we aimed to test their utility in the clinical practice for the purposes of identification of the patients who will most likely end up with a poor outcome, as well as to test their utility for clinical decision making between conservative and surgical intervention. Methods: 20 patients with ICH were included initially in this pilot longitudinal study. Their peripheral blood TNF-α levels were screened, and the risk for poor outcome was assessed by using our previously determined cutoff value of > 110.35 pg/mL. The neurological outcome was determined 3 months after the initial hemorrhagic cerebrovascular insult. Another series of 20 threatened patients with TNF-α levels higher than 200 pg/mL were tested for the possibility of lowering the risk of the poor outcome by implementing early craniotomy with hematoma evacuation. Results: The value of > 110.35 pg/mL had fairly identified the patients who later fell into the group with poor outcome, 3 months after ICH (8 out of 9 identified patients with risk for poor outcome have resulted in a poor outcome). In the second series of 20 threatened patients with TNF-α levels higher than 200 pg/mL, early craniotomy and evacuation of the hematoma were shown beneficial; 7 out of 20 patients resulted in a good outcome. Conclusions: TNF-α screening at admission was shown as a useful method for identifying the ICH patients with the highest risk for ending with poor neurological outcome; early craniotomy with hematoma evacuation in the threatened group of patients with the highest TNF-α levels has also shown benefit in lowering the risk for poor outcome and improving patient's neurological state 3 months after ICH.
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    SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms
    (Elsevier BV, 2018-05)
    Aleksovski, Boris
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    Neceva, Violeta
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    Vujović, Viktorija
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    Adverse effects with bleeding disorders are often associated with the administration of SSRI in depression, although the exact mechanisms remain contradicting. This study is aimed at detecting and exploring the mechanisms of SSRI-induced changes in platelet reactivity in non-responding patients with Recurrent Depressive Disorder (RDD) and life-long exposure to antidepressants.
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    Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume
    (VM Media SP. zo.o VM Group SK, 2018-03)
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    Aleksovski, Boris
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    Stojanov, Dragan
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    Aleksovski, Vasko
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    Mihajlovska Rendevska, Ana
    We aimed to evaluate the prognostic values, contribution and interactions of the peripheral blood plasma glutamate and tumor-necrosis factor-α (TNF-α) levels toward the formation of the perifocal edema in patients with intracerebral hemorrhage (ICH).
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    Surgical Outcome in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage
    (Walter de Gruyter GmbH, 2017-12-01)
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    Stojanov, Dragan
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    Aleksovski, Boris
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    Mihajlovska Rendevska, Ana
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    <jats:title>Summary</jats:title> <jats:p>The aim of the paper was to evaluate the surgical outcome in patients with spontaneous supratentorial intracerebral hemorrhage (ICH) after surgical intervention, in respect to the initial clinical conditions, age, sex, hemispheric side and anatomic localization of ICH. Thirty-eight surgically treated patients with spontaneous supratentorial intracerebral hemorrhage were included in the study. The surgical outcome was evaluated three months after the initial admission, according to the Glasgow Outcome Scale (GOS). The surgical treatment was successful in 14 patients (37%), whereas it was unsuccessful in 24 patients (63%). We have detected a significant negative correlation between the Glasgow Coma Scale (GCS) scores on admission and the GOS scores after three months, suggesting worse neurological outcome in patients with initially lower GCS scores. The surgical outcome in patients with ICH was not affected by the sex, the hemispheric side and the anatomic localization of ICH, but the age of the patients was estimated as a significant factor for their functional outcome, with younger patients being more likely to be treated successfully. The surgical outcome is affected from the initial clinical state of the patients and their age. The treatment of ICH is still an unsolved clinical problem and the development of new surgical techniques with larger efficiency in the evacuation of the hematoma is necessary, thus making a minimal damage to the normal brain tissue, as well as decreasing the possibility of postoperative bleeding.</jats:p>
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    Modeling prognostic factors for poor neurological outcome in conservatively treated patients with intracerebral hemorrhage: A focus on TNF-α
    (Elsevier BV, 2018-09)
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    Aleksovski, Boris
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    Stojanov, Dragan
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    Mihajlovska Rendevska, Ana
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    Aleksovski, Vasko
    Prognostic models for Intracerebral hemorrhage (ICH), mainly based on clinical evaluation, have remained inherently confounded by subjective scoring assessments and limited accuracy. In this study, we aimed at assessing the risk for poor outcome after ICH based on peripheral biochemical markers (TNF-α, glutamate and glucose) and radiological variables (both at admission and five days after patient's care), for modeling purposes of prognostication.
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    Effects of data transformation on multivariate analyses in intracerebral hemorrhage
    (Macedonian Pharmaceutical Association, 2016)
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    Aleksovski, Boris
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    Kolevska, Milena
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    Stojanov, Dragan
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    <jats:p>Multivariate statistical approaches have been increasingly applied in hemorrhagic stroke data analysis. Nevertheless, several aspects regarding their relevance and validity in respect of the application of data transformations have not been studied in details. This paper examines the effects of different data transformations in the standard statistical methods of the multivariate analysis of the intracerebral hemorrhage (ICH) parameters in small group samples. Two different methods for data transformations (log transformation (log(Xi )), square root transformation (√Xi ))have been carried out. The initial volume of the ICH have been studied using several test for skewness, kurtosis, histogram distribution method and different quartile-quartile (Q-Q) and probability-probability (P-P) plots as criteria for normal distribution. Multivariate analyses for the prediction of the perifocal edema was performed using raw and transformed data. Our results indicate that the data transformation operations should be performed very carefully because different analytical outputs lead to different scientific conclusions.</jats:p>
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    Evaluation of peripheral serotonin content and α2-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements
    (Informa UK Limited, 2018-09)
    Aleksovski, Boris
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    Vujović, Viktorija
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    We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet α2-adrenergic receptors (α2-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD).
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    Kinetics of Antibody Response to Repeated Vaccination with Sputnik V: A Pilot Study with a Series of Five Cases
    (2022-08)
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    Aleksovski, Vasko
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    Widespread vaccination is considered as one of the best methods in combating any pandemic including COVID-19. Gam-COVID-Vac also known as Sputnik V, is one of the first vaccines that was registered in 74 countries and received an emergency approval for immunization. Monitoring anti-SARS-CoV-2 antibodies over time is essential for evaluation of post-vaccination humoral immune response.To date, there are only a limited number of clinical studies regarding the analysis of immune response after Sputnik V administration. It is of crucial importance to report independently on safety and efficiency of this vaccine with the aim to speed up the process of its final approval by the WHO.