Faculty of Medicine
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Item type:Publication, Tumour budding – an additional prognostic facto r in colorectal cancer survival(Termedia, 2023-03); Sedat KamallTumour budding (TB) in cancer is a phenomenon of tumour cells forming clusters, and it is associated with an epithelial-mesenchymal transition into the extracellular matrix of the tumour. It has been shown that the presence of TB in colorectal cancer (CRC) is associated with worse overall survival, higher possibility for vessel invasion, lymph node involvement, and distant metastases appearance. In this retrospective study TB presence in operated patients for CRC is analysed. In the data from 81 patients, 26 presented with TB. Analysis revealed high statistical significance of the effect of TB presence on the number of metastatic lymph nodes, and the lymphovascular and perineural invasion. A statistically meaningful correlation was found between the presence of TB and CRC survival (p = 0.016). Patients with right-sided colon cancer presented with worse overall survival (p = 0.011). The patients who presented lymph node metastases and TB presence had worse overall survival (p = 0.026 and p = 0.021, respectively). Tumour budding, tumour location, and age over 64 years are found to be the independent prognostic factors in CRC patients. Tumour budding is an important prognostic factor in CRC patients that will contribute to treatment. Pathological examination must consider TB in detail. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intra and Postoperative Advantages of Laparoscopy in the Treatment of Complicated Appendicitis(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Sciendo, 2022-07); Cemal UlusoyAim: To determine and define the advantages of the laparoscopic appendectomy in the treatment of complicated appendicitis by comparing it with the open appendectomy. Material and Methods: In this prospective interventional clinical study we compared the intraoperative data and the postoperative outcome of 77 patients presented with complicated appendicitis, operated with open and laparoscopic appendectomy within a period of 20 months. One surgeon performed all of the laparoscopic procedures and two other senior surgeons performed the open procedures. Results: Operative time was shorter in the laparoscopic group (p = 0.033). Conversion rate was 2.3%. Overall postoperative morbidity was 25.97%. There was one operative revision due to postoperative small bowel obstruction in the laparoscopic group. Appendicular stump leakage occurred in one patient in the open group. One intra-abdominal abscess occurred in the laparoscopic group (p = 0.38). Wound infection occurred only in the open group (p = 0.018). Length of stay was shorter in the laparoscopic group (p = 0.0052). One patient from the laparoscopic group was readmitted. Conclusions: Laparoscopy is a reliable method in the treatment of complicated appendicitis. It offers a shorter operative time, low conversion rate, an acceptable rate of major postoperative complications and a shorter length of stay. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Medically treated emphysematous gastritis in a patient with rheumatoid arthritis: report of case(DergiPark Akademik, 2021-12-14); ; Tuba SaydamEmphysematous gastritis is rare infection of the gastric wall associated with high mortality. Damage of the gastric mucosal barrier and bacterial translocation can lead to emphysematous gastritis. Non-steroidal anti-inflammatory drugs use is one of the etiological factors. Due to the high mortality rates, early diagnosis and treatment is important. Patients are presenting to emergency departments generally with non-specific acute abdominal signs. We present a case of an 82 years old patient with rheumatoid arthritis treated with non-steroidal anti-inflammatory drug that presented to the emergency department with diffuse abdominal pain, nausea and vomiting. After establishing the diagnosis, conservative treatment was conducted with success.