Tumour budding – an additional prognostic facto r in colorectal cancer survival
Journal
Polish Journal of Pathology
Date Issued
2023-03
Author(s)
Gülçİn Harman Kamall
Cemal Ulusoy
Sedat Kamall
DOI
10.5114/pjp.2023.127040
Abstract
Tumour budding (TB) in cancer is a phenomenon of tumour cells forming clusters,
and it is associated with an epithelial-mesenchymal transition into the extracellular
matrix of the tumour. It has been shown that the presence of TB in colorectal
cancer (CRC) is associated with worse overall survival, higher possibility for vessel
invasion, lymph node involvement, and distant metastases appearance.
In this retrospective study TB presence in operated patients for CRC is analysed.
In the data from 81 patients, 26 presented with TB.
Analysis revealed high statistical significance of the effect of TB presence on the number
of metastatic lymph nodes, and the lymphovascular and perineural invasion.
A statistically meaningful correlation was found between the presence of TB and CRC
survival (p = 0.016). Patients with right-sided colon cancer presented with worse
overall survival (p = 0.011). The patients who presented lymph node metastases
and TB presence had worse overall survival (p = 0.026 and p = 0.021, respectively).
Tumour budding, tumour location, and age over 64 years are found to be the independent
prognostic factors in CRC patients. Tumour budding is an important
prognostic factor in CRC patients that will contribute to treatment. Pathological
examination must consider TB in detail.
and it is associated with an epithelial-mesenchymal transition into the extracellular
matrix of the tumour. It has been shown that the presence of TB in colorectal
cancer (CRC) is associated with worse overall survival, higher possibility for vessel
invasion, lymph node involvement, and distant metastases appearance.
In this retrospective study TB presence in operated patients for CRC is analysed.
In the data from 81 patients, 26 presented with TB.
Analysis revealed high statistical significance of the effect of TB presence on the number
of metastatic lymph nodes, and the lymphovascular and perineural invasion.
A statistically meaningful correlation was found between the presence of TB and CRC
survival (p = 0.016). Patients with right-sided colon cancer presented with worse
overall survival (p = 0.011). The patients who presented lymph node metastases
and TB presence had worse overall survival (p = 0.026 and p = 0.021, respectively).
Tumour budding, tumour location, and age over 64 years are found to be the independent
prognostic factors in CRC patients. Tumour budding is an important
prognostic factor in CRC patients that will contribute to treatment. Pathological
examination must consider TB in detail.
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