HELICOBACTER PYLORI INFECTION IN NEVER-SMOKING MALE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO LUNG FUNCTION
Journal
American Journal of Immunology
Date Issued
2012-04-01
Author(s)
Snezana Risteska-Kuc
DOI
10.3844/ajisp.2012.146.153
Abstract
There is a recent epidemiologic and serologic evidence for relationship between Helicobacter pylori
(H. pylori) infection and Chronic Obstructive Pulmonary Disease (COPD). In order to assess the
relationship between H. pylori infection and COPD and its impact on lung function we performed a
cross-sectional study including 84 never-smoking male patients with COPD and an equal number of
never-smoking males without chronic respiratory disease matched to the COPD patients by age.
Evaluation of the study subjects included evaluation of H. pylori serological status, baseline and postbronchodilator
spirometry. We found significantly higher H. pylori seropositivity in COPD patients
than in controls (76.2 Vs 34.5%, p = 0.041). The prevalence of H. pylori seropositivity did not differ
significantly between patients with mild, moderate and severe COPD. Borderline significance was
registered for the difference of the forced expiratory volume in one second (FEV1) mean value between
seropositive and seronegative COPD patients (56.4 vs. 59.2, p = 0.063). The mean degree of FEV1
reversibility did not differ significantly between seropositive and seronegative COPD patients. Our
findings indicate that in cross-sectional analysis there is higher prevalence of H. pylori seropositivity
in COPD than in non-COPD patients, as well as that H. pylori infection has not significant impact on
lung function in COPD patients.
(H. pylori) infection and Chronic Obstructive Pulmonary Disease (COPD). In order to assess the
relationship between H. pylori infection and COPD and its impact on lung function we performed a
cross-sectional study including 84 never-smoking male patients with COPD and an equal number of
never-smoking males without chronic respiratory disease matched to the COPD patients by age.
Evaluation of the study subjects included evaluation of H. pylori serological status, baseline and postbronchodilator
spirometry. We found significantly higher H. pylori seropositivity in COPD patients
than in controls (76.2 Vs 34.5%, p = 0.041). The prevalence of H. pylori seropositivity did not differ
significantly between patients with mild, moderate and severe COPD. Borderline significance was
registered for the difference of the forced expiratory volume in one second (FEV1) mean value between
seropositive and seronegative COPD patients (56.4 vs. 59.2, p = 0.063). The mean degree of FEV1
reversibility did not differ significantly between seropositive and seronegative COPD patients. Our
findings indicate that in cross-sectional analysis there is higher prevalence of H. pylori seropositivity
in COPD than in non-COPD patients, as well as that H. pylori infection has not significant impact on
lung function in COPD patients.
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