Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/9758
DC Field | Value | Language |
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dc.contributor.author | Curakova Ristovska, Elena | en_US |
dc.contributor.author | Genadieva Dimitrova, Magdalena | en_US |
dc.contributor.author | Caloska-Ivanova Viktorija | en_US |
dc.contributor.author | Misevski Jane | en_US |
dc.date.accessioned | 2020-12-23T12:42:06Z | - |
dc.date.available | 2020-12-23T12:42:06Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1784-3227 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/9758 | - |
dc.description.abstract | Introduction and aim : Endothelial dysfunction is involved in the pathogenesis of portal hypertension and in the progression of liver disease. As an indicator of endothelial dysfunction, von Willebrand factor (vWF-Ag) can be a useful mortality predictor in patients with liver cirrhosis. The aim of the study is to compare the predictive value of vWF-Ag with the predictive value of MELD score regarding the three-month mortality in patients with liver cirrhosis. Materials and methods : In 70 patients with cirrhosis and portal hypertension we measured the vWF-Ag concentration and we followed the patients for 90 days. We registered all manifestations and complications of liver cirrhosis and the three-month mortality was the main end-point. Results : We registered mean vWF-Ag of 341.9±155.8%, median 312%, IQR (214-410), vWF-Ag significantly correlated with MELD score (R=0.3713 ; p<0.05) and vWF-Ag median was higher in the uncensored compared to the median in the censored patients (p<0.0067). vWF-Ag and MELD score were significantly associated with three-month mortality, with no significant difference in the diagnostic performance between the two parameters [AUC=0.735, p=0.007 for vWF-Ag ; AUC=0.885, p=0.000 for MELD score], (Z=-1.473, p=0.1407). Conclusion : In patients with liver cirrhosis vWF-Ag is a relevant predictor of three-month mortality that equals the MELD score. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Universa Press | en_US |
dc.relation.ispartof | Acta Gastro-Enterologica Belgica | en_US |
dc.subject | von-Willebrand factor | en_US |
dc.subject | mortality | en_US |
dc.subject | cirrhosis | en_US |
dc.subject | endothelial dysfunction | en_US |
dc.title | Von-Willebrand factor as a predictor of three-month mortality in patients with liver cirrhosis compared to MELD score | en_US |
dc.type | Article | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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Von-Willebrand factor as a predictor of three-month mortality in patients with liver cirrhosis compared to MELD score.pdf | 1.01 MB | Adobe PDF | View/Open |
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