Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/9680
Title: Analysis of etiological factors for emergence of endometrial hyperplasia in perimenopause
Other Titles: АНАЛИЗА НА ЕТИОЛОШКИ ФАКТОРИ ЗА ПОЈАВА НА ЕНДОМЕТРИЈАЛНА ХИПЕРПЛАЗИЈА ВО ПЕРИМЕНОПАУЗA
Authors: Aneta Sima
Anita Arsovska 
Simeonova Krstevska, Slagjana
Ana Daneva Markova 
Dabeski, Drage 
Keywords: endometrial hyperplasia
risk factors
perimenopause
Issue Date: 15-Jun-2019
Publisher: Институт за јавно здравје на Р Северна Македонија = Institute of Public Health of R North Macedonia
Journal: Архиви на јавното здравје = Archives of Public Health
Abstract: The aim of this study was to evaluate the possible reasons for the emergence of endometrial hyperplasia in perimenopause. Material and methods: A total of 71 patients with irregular bleeding were analyzed, at the age of 40-50 years, who should have undergone diagnostic curettage. Depending on the histopathological findings, we divided them into 2 groups: group 1-findings for endometrial hyperplasia, group 2 - atrophic or endometrium with deficient secretory changes. Body mass index (BMI) was determined (obesity defined with BMI >30 kg/m2); we measured blood pressure (cut-off value was 135/90 mmHg), waist circumference (cut-off value was 88 cm) as well as data of anamnesis (age, physical activity, type of diet, smoking cigarettes). All these data were analyzed as etiological factors in the emergence of endometrial hyperplasia. Results: The mean age of patients was 47 years, and the results obtained were very similar in both examined groups. BMI and waist circumference were increased, more than 60% of patients had hypertension, but not all had a statistical significance. Most of them were with completed secondary education, and city living statistically significantly increases the risk of endometrial hyperplasia (p <0.05). As for the lifestyle (physical activity, caloric diet, smoking), the results have shown that a small number of patients are active, almost half of them consume caloric food and smoke, but without a statistical significance. Conclusion: Increased body weight and elevated blood pressure have a major impact on the onset and progression of pathological changes in the endometrium. As clinicians, we should always think of hyperplasia in obesity and patients with hypertension who are irregularly bleeding. At the same time, we should educate them to change the lifestyle in order to prevent gynecological and internistic morbidity.
URI: http://hdl.handle.net/20.500.12188/9680
DOI: https://doi.org/10.3889/aph.2019.3576
Appears in Collections:Faculty of Medicine: Journal Articles

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