Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure

Nikolov, Igor G; Joki, Nobuhiko; Nguyen-Khoa, Thao; Ivanovski, Ognen; Phan, Olivier; Lacour, Bernard; Drüeke, Tilman B; Massy, Ziad A; Dos Reis, Luciene Machado; Jorgetti, Vanda; Lafage-Proust, Marie-Hélène

doi:10.1016/j.bone.2010.04.600

Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure

Journal

Bone

Date Issued

2010-07

Author(s)

Joki, Nobuhiko

Nguyen-Khoa, Thao

Phan, Olivier

Lacour, Bernard

Drüeke, Tilman B

Massy, Ziad A

Dos Reis, Luciene Machado

Jorgetti, Vanda

Lafage-Proust, Marie-Hélène

DOI

10.1016/j.bone.2010.04.600

Abstract

Chronic kidney disease (CKD) is associated with disorders of mineral and bone metabolism (MBD) which include renal osteodystrophy and vascular calcifications. This is of clinical concern because the high risk of cardiovascular (CVD) complications observed in uremic patients may be linked with bone disease. In this context, our aim was to characterize the bone lesions in CKD-apolipoprotein E-deficient mice (apoE(-/-)) and analyze their relationships with the vascular calcifications which these animals develop rapidly in this model. With ApoE being also involved in bone metabolism, we compared the effects of CRF on the bone of apoE(-/-) mice to those observed in wild type mice (WT) of the same genetic background, C57/BL6.