Effect of oral calcium carbonate on aortic calcification in apolipoprotein E-deficient (apoE-/-) mice with chronic renal failure

Phan, Olivier; Ivanovski, Ognen; Nikolov, Igor G; Joki, Nobuhiko; Maizel, Julien; Louvet, Loïc; Chasseraud, Maud; Nguyen-Khoa, Thao; Lacour, Bernard; Drüeke, Tilman B; Massy, Ziad A

doi:10.1093/ndt/gfm699

Effect of oral calcium carbonate on aortic calcification in apolipoprotein E-deficient (apoE-/-) mice with chronic renal failure

Journal

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Date Issued

2008-01

Author(s)

Phan, Olivier

Joki, Nobuhiko

Maizel, Julien

Louvet, Loïc

Chasseraud, Maud

Nguyen-Khoa, Thao

Lacour, Bernard

Drüeke, Tilman B

Massy, Ziad A

DOI

10.1093/ndt/gfm699

Abstract

In chronic kidney disease (CKD) patients, the intake of calcium-based phosphate binders is associated with a marked progression of coronary artery and aortic calcification, in contrast to patients receiving calcium-free phosphate binders. The aim of this study was to reexamine the role of calcium carbonate in vascular calcification and to analyse its effect on aortic calcification-related gene expression in chronic renal failure (CRF).