IMMUNOGENETIC ASPECTS OF THE ORIGIN OF PREECLAMPSIA

Abstract

The combinations of genes of the fetal HLA-C and the maternal KIR affects the pregnancy outcome. Objective: to examine patients in second trimester of pregnancy by predicting that a change in the immune response may be demonstrated before the development of preeclampsia symptomatology. Material and Methods: For the purpose of this study, 100 patients were examined in the second trimester, at the University Clinic of Gynecology and Obstetrics and at the Institute of Immunobiology and Human Genetics in Skopje, which analyzed serum levels of cytokines, proinflammatory compared to antiinflamatory antibodies. Results: The results were obtained using ELISA methodology. Of the above 100 patients, 21% developed clinical preeclampsia syndrome. In them, there was a change in values in addition to an increase in TNF - S, IL-6, IL-2, IL-1S at the same time a tendency for a decrease in IL-10 was observed. IL-4 showed no variation in its value. Conclusion: In our research paper, proinflammatory interleukin TNF-S increases, and by means of Pearson’s correlation between variables it is verified that not only does it grow, but it grows concurrently with IL-6, which is a statistically significant result, or p <0.05. IL-1S increases concurrently with TNF-S, which corresponds to the following studies in support of our study.