THE IMPACT OF THYROID STIMULATING HORMONE (TSH), TOTAL THYROXINE (TT4) AND URINARY IODINE CONCENTRATION (UIC) ON NEONATAL OUTCOME AND PRETERM DELIVERY
Journal
Macedonian Medical Journal/Македонски медицински преглед
Date Issued
2020
Author(s)
Maja Avramovska
Borislav Karanfilski
Abstract
Introduction. Impaired maternal thyroid metabolism
is associated with poor outcomes for the mother, the
developing newborn and preterm delivery. The aim of
this study was to investigate the impact of thyroid stimulating
hormone (TSH), total thyroxine (TT4) and
urinary iodine concentration (UIC) on neonatal outcome
and preterm delivery.
Methods. From the cohort of 358 healthy pregnant
women (mean age 30.15±5.26 years)three subgroups
were formed accordingto gestational week of pregnancy.
TSH and TT4 were analyzed with time-resolved fluoroimmunoassay
and UIC by mass spectrometry. Correlation
of thyroid parameters with other variables was
analyzed by Pierson’s correlation test. Logistic regressionwas
used to predict the neonatal outcome and
preterm delivery. Receiver operating characteristics
curve analysis was used to calculate cut-off value of
TT4 as predictors of treating preterm delivery (TPD).
Results. There was a statistically significant difference
in TSH (0.471±0.82 mIU/L vs. 0.544±0.337 mIU/L,
P=0.016) betweenprematurely delivered and delivered
atterm. TSH had a statistically significant predictive impact
on the !PD in the second trimester (Exp &=-0.0532,
Wald=4.6003, P=0.032). TT4 assumed a predictive
impact in thethird trimester (Exp &=1.0227, Wald=6.0254,
P=0.014). The cut-off point of TT4 in detecting of
TPD was131.3 nmol/L, area under the curve =0.66.
Conclusion. The results of this study suggest that values
of maternal TT4 and TSH show possible predictive
impact of preterm birthin the second and third
trimester, which varies by gestational age.
is associated with poor outcomes for the mother, the
developing newborn and preterm delivery. The aim of
this study was to investigate the impact of thyroid stimulating
hormone (TSH), total thyroxine (TT4) and
urinary iodine concentration (UIC) on neonatal outcome
and preterm delivery.
Methods. From the cohort of 358 healthy pregnant
women (mean age 30.15±5.26 years)three subgroups
were formed accordingto gestational week of pregnancy.
TSH and TT4 were analyzed with time-resolved fluoroimmunoassay
and UIC by mass spectrometry. Correlation
of thyroid parameters with other variables was
analyzed by Pierson’s correlation test. Logistic regressionwas
used to predict the neonatal outcome and
preterm delivery. Receiver operating characteristics
curve analysis was used to calculate cut-off value of
TT4 as predictors of treating preterm delivery (TPD).
Results. There was a statistically significant difference
in TSH (0.471±0.82 mIU/L vs. 0.544±0.337 mIU/L,
P=0.016) betweenprematurely delivered and delivered
atterm. TSH had a statistically significant predictive impact
on the !PD in the second trimester (Exp &=-0.0532,
Wald=4.6003, P=0.032). TT4 assumed a predictive
impact in thethird trimester (Exp &=1.0227, Wald=6.0254,
P=0.014). The cut-off point of TT4 in detecting of
TPD was131.3 nmol/L, area under the curve =0.66.
Conclusion. The results of this study suggest that values
of maternal TT4 and TSH show possible predictive
impact of preterm birthin the second and third
trimester, which varies by gestational age.
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