Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/9228
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Emilija Antova | en_US |
dc.contributor.author | Lidija Petkovska | en_US |
dc.contributor.author | Marijan Bosevski | en_US |
dc.contributor.author | Jagoda Stojkovic | en_US |
dc.contributor.author | Nikola Hadzy-Petrushev | en_US |
dc.contributor.author | Andre Kamkin | en_US |
dc.contributor.author | Mitko Mladenov | en_US |
dc.date.accessioned | 2020-09-28T08:56:17Z | - |
dc.date.available | 2020-09-28T08:56:17Z | - |
dc.date.issued | 2018-08-13 | - |
dc.identifier.issn | 1857-9345 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/9228 | - |
dc.description.abstract | Background: The aim was to evaluate the Nt-proBNP discriminatory role between symptomatic and asymptomatic patients with severe aortic stenosis. Methods: 187 patients with severe valvular aortic stenosis, with normal EF > 50%, were included, 61 asymptomatic and 126 symptomatic. We used clinical, laboratory (Nt-proBNP) and echocardiographic parameters. Endpoints of monitoring (occurrence of event) were: the onset of symptoms in asymptomatic patients and death in both groups. Results: The symptomatic group with severe AS had a significantly higher means of Nt-proBNP, in comparison with the asymptomatic group. Nt-proBNP was a significant predictor for the risk of event occurrence (HR 1.4). In the group of severe AS without CAD (n = 101), the subgroup with Nt-proBNP above the cut-off value, took significantly higher percentage of patients with chest pain, fatigue and syncope. In the group with Nt-proBNP above the cut-off value, we had a significantly higher percentage of patients with severe AS without CAD, compared to those with CAD (n = 142). Nt-proBNP was negatively correlated with AVA and LVEF, whether the positive correlation was expressed for: LVEDd, LVEDs, IVSd, AV_Vmax, AV_MaxGrad, LVM and LA. Patients with Nt-proBNP above the cut-off, had a significantly lower event free survival, compared to patients with Nt-proBNP below the cut-off (n = 187; n = 101). Conclusion: The Nt-proBNP cut-off> 460 pg/ml was confirmed as a useful tool in the determination of event free survival in patients with severe AS. Nt-proBNP not only had relevance in the assessment of the severity of the disease, but also was a significant predictor for the risk of event occurrence. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Macedonian Academy of Sciences and Arts | en_US |
dc.relation.ispartof | Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) | en_US |
dc.subject | Aortic stenosis | en_US |
dc.subject | N-terminal pro-B-type natriuretic peptide | en_US |
dc.subject | Echocardiography | en_US |
dc.subject | Aortic valve replacement | en_US |
dc.title | Nt-proBNP DISCRIMINATORY ROLE BETWEEN SYMPTOMATIC AND ASYMPTOMATIC PATIENTS WITH SEVERE VALVULAR AORTIC STENOSIS | en_US |
dc.type | Article | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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