Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/9228
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dc.contributor.authorEmilija Antovaen_US
dc.contributor.authorLidija Petkovskaen_US
dc.contributor.authorMarijan Bosevskien_US
dc.contributor.authorJagoda Stojkovicen_US
dc.contributor.authorNikola Hadzy-Petrusheven_US
dc.contributor.authorAndre Kamkinen_US
dc.contributor.authorMitko Mladenoven_US
dc.date.accessioned2020-09-28T08:56:17Z-
dc.date.available2020-09-28T08:56:17Z-
dc.date.issued2018-08-13-
dc.identifier.issn1857-9345-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/9228-
dc.description.abstractBackground: The aim was to evaluate the Nt-proBNP discriminatory role between symptomatic and asymptomatic patients with severe aortic stenosis. Methods: 187 patients with severe valvular aortic stenosis, with normal EF > 50%, were included, 61 asymptomatic and 126 symptomatic. We used clinical, laboratory (Nt-proBNP) and echocardiographic parameters. Endpoints of monitoring (occurrence of event) were: the onset of symptoms in asymptomatic patients and death in both groups. Results: The symptomatic group with severe AS had a significantly higher means of Nt-proBNP, in comparison with the asymptomatic group. Nt-proBNP was a significant predictor for the risk of event occurrence (HR 1.4). In the group of severe AS without CAD (n = 101), the subgroup with Nt-proBNP above the cut-off value, took significantly higher percentage of patients with chest pain, fatigue and syncope. In the group with Nt-proBNP above the cut-off value, we had a significantly higher percentage of patients with severe AS without CAD, compared to those with CAD (n = 142). Nt-proBNP was negatively correlated with AVA and LVEF, whether the positive correlation was expressed for: LVEDd, LVEDs, IVSd, AV_Vmax, AV_MaxGrad, LVM and LA. Patients with Nt-proBNP above the cut-off, had a significantly lower event free survival, compared to patients with Nt-proBNP below the cut-off (n = 187; n = 101). Conclusion: The Nt-proBNP cut-off> 460 pg/ml was confirmed as a useful tool in the determination of event free survival in patients with severe AS. Nt-proBNP not only had relevance in the assessment of the severity of the disease, but also was a significant predictor for the risk of event occurrence.en_US
dc.language.isoenen_US
dc.publisherMacedonian Academy of Sciences and Artsen_US
dc.relation.ispartofPrilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)en_US
dc.subjectAortic stenosisen_US
dc.subjectN-terminal pro-B-type natriuretic peptideen_US
dc.subjectEchocardiographyen_US
dc.subjectAortic valve replacementen_US
dc.titleNt-proBNP DISCRIMINATORY ROLE BETWEEN SYMPTOMATIC AND ASYMPTOMATIC PATIENTS WITH SEVERE VALVULAR AORTIC STENOSISen_US
dc.typeArticleen_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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