Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report)
Journal
Open Access Macedonian Journal of Medical Sciences
Date Issued
2016-12-15
Author(s)
Sead Zejnel
Dragana Stojkovic
Martin Trajkovski
Angela Debreslioska
Smilko Jovanovski
Abstract
BACKGROUND: Goodpasture syndrome was originally described as an association of alveolar
haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys
healthy body tissue.
AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and
glomerulonephritis, which is diagnosed by renal biopsy.
CASE PRESENTATION: His illness began a year and a half before being diagnosed. In that period
he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and
after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was
8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was:
Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was
diagnosed with Goodpasture syndrome. He received corticosteroid therapy and cyclophosphamide,
with good response to treatment, and he is currently in a stable condition, receiving only
corticosteroid therapy.
CONCLUSION: Goodpasture syndrome is a severe illness caused by the formation of antibodies to
the glomerular basement membrane and alveolus with consequential damage to renal and
pulmonary function. With current therapy, long-term survival is more than 50%
haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys
healthy body tissue.
AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and
glomerulonephritis, which is diagnosed by renal biopsy.
CASE PRESENTATION: His illness began a year and a half before being diagnosed. In that period
he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and
after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was
8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was:
Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was
diagnosed with Goodpasture syndrome. He received corticosteroid therapy and cyclophosphamide,
with good response to treatment, and he is currently in a stable condition, receiving only
corticosteroid therapy.
CONCLUSION: Goodpasture syndrome is a severe illness caused by the formation of antibodies to
the glomerular basement membrane and alveolus with consequential damage to renal and
pulmonary function. With current therapy, long-term survival is more than 50%