Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain

Dzambazovska Trajkovska, Vanja; Nojkov, Jordan; Kartalov, Andrijan; Kuzmanovska, Biljana; Spiroska, Tatjana; Seljmani, Redzep; Trajkovski, Gjorgji; Matevska Geshkovska, Nadica; Dimovski, Aleksandar

doi:10.1515/prilozi-2016-0019

Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain

Journal

Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)

Date Issued

2016-11-01

Author(s)

Nojkov, Jordan

Spiroska, Tatjana

Seljmani, Redzep

Matevska Geshkovska, Nadica

DOI

10.1515/prilozi-2016-0019

Abstract

The minimal effective analgesic concentration of opioids required for satisfactory analgesia may differ significantly among the patients. Genetic factors may contribute to the variable response to opioids by affecting their pharmacokinetics or pharmacodynamics.