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http://hdl.handle.net/20.500.12188/8820
Title: | Sentinel Lymph Node Detection in Breast Cancer – First Experience | Other Titles: | Детекција на сентинелни лимфни Јазли кај карцином на дојка – први искуства | Authors: | Stojanoski, Sinisa Ristevska, Nevena Pop Gjorcheva, Daniela Antevski, Borce Petrushevska, Gordana |
Issue Date: | 1-May-2015 | Publisher: | Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH | Journal: | Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) | Abstract: | <jats:title>Abstract</jats:title> <jats:p> Introduction: Breast cancer accouns for 22.9% of all cancers in women and 13.7% of cancer deaths. Positive axillary lymphnodes (ALN) predict the development of distant metastases. The status of the sentinel lymphnode (SLN) is crutial for the treatment selection. </jats:p> <jats:p>Aim: To determine the benefits of SLN detection in patients with breast cancer. Material and methodology: 38 female patients (pts), age 44 ± 12 years, with T1-2 N0 M0 breast cancer, without enlarged ALN on ultrasound (US), were included. SLN detection was performed using gamma camera and gamma detection probe after periareolar subcutaneous and/or peritumoral injection of (99m-Technetium-SENTISCINT). Blue dye was administered 20 min before the operation. SLN was extirpated and ex tempore histopathology was performed. </jats:p> <jats:p>Results: Ex tempore SLN evaluation was negative and the lymphatic pathways preserved in 28/38 (74%) pts. In 10/38 (26%) pts SLN was positive, followed by radical surgery. In 3/28 ex tempore negative patients, histopathological analysis showed metastatic involvement (false negative). In 3/10 ex tempore positive patients micro metastases 0,2-2 mm were detected. 12 pts had 2 SLN, 8/12 (66%) had negative and 4/12 (34%) had positive SLN. 3 pts had a rare double drainage to axilla and a. mammaria int. </jats:p> <jats:p>Conclusion: Our results confirm that SLN detection technique is non-invasive, safe and reliable and should be incorporated into the guidelines for breast cancer pts (T1-2 N0 M0). The most reliable option for colloid application is the combined technique of periareolar and peritumoral injection. Patients with drainage to a. mammaria interna should be selected for adjuvant protocols.</jats:p> | URI: | http://hdl.handle.net/20.500.12188/8820 | DOI: | 10.1515/prilozi-2015-0039 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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