Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/8658
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dc.contributor.authorPetrovska, Sunchicaen_US
dc.contributor.authorManchevska, Sanjaen_US
dc.contributor.authorDejanova, Betien_US
dc.contributor.authorJ. Pluncevic Gligoroskaen_US
dc.date.accessioned2020-07-07T14:08:48Z-
dc.date.available2020-07-07T14:08:48Z-
dc.date.issued2017-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/8658-
dc.description.abstractPremenopausal women have a decreased incidence of cardiovascular disease and a decreased rate of progression of renal disease. With the onset of menopause, however, decreased synthesis of 17β-estradiol (estradiol) is accompanied by an increased incidence of cardiovascular disorders and accelerated progression of renal diseases. The glomerulus and the vascular wall are not static, and components of these structures dynamically increase, decrease, or reorganize in response to physiological and pathological stimuli. Although multiple cellular and biochemical processes are involved in glomerular and vascular remodelling, glomerular mesangial cells (GMCs) in the kidney and smooth muscle cells (VSMC) and endothelial cells in the vasculature are the final common pathway for dynamic changes in glomerular and vascular wall structure. Estradiol may induce protective effects on the renal and cardiovascular system by altering VSMC, GMC, or endothelial cell biology so as to prevent glomerular and vascular remodelling. The purpose of this review is to provide an overview of the participating mechanisms in this regard, as well as the mechanism of estradiol signalling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection.en_US
dc.language.isoenen_US
dc.publisherFaculty of Physical Education, Sport and Health in Skopjeen_US
dc.relation.ispartofResearch in Physical Education, Sport and Healthen_US
dc.subjectestrogens,en_US
dc.subjectpremenopause,en_US
dc.subjectvascular wall,en_US
dc.subjectcardiomyocytesen_US
dc.titleESTRADIOL: MECHANISM OF CARDIORENAL PROTECTIONen_US
dc.typeArticleen_US
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.eissn1857-8160-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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