Influence of Duration of Heroin Dependence on Humoral Immunologic Indicators
Journal
Journal of Addiction Medicine
Date Issued
2016-06
Author(s)
Irena Jurukov
Liljana Trenchevska-Siljanovska
DOI
10.1097/adm.0000000000000259
Abstract
Objective: The incidence of autoantibodies may be associated with
the duration of drug use. In this study, we assessed the association
between the duration of heroin dependence and various humoral
immunologic indicators, including IgA, IgG, IgM, complement
component 3, complement component 4, rheumatoid factor, antib2-glycoprotein 1 (IgA, IgG, IgM), antinuclear antibody, circulating
immune complexes, and cryoglobulins.
Methods: A total of 363 patients with heroin dependence were
enrolled in this cross-sectional and prospective study over a 3.5-
year period. Depending on the duration of heroin use, participants
were divided into 3 groups: up to 3 years, 4 to 7 years, and more than
7 years of heroin dependence. All patients were analyzed for the
indicators.
Results: There was a significant difference between the duration of
heroin dependence and increased concentration of IgA (P ¼ 0.0000),
IgG (P ¼ 0.0000), IgM (P ¼ 0.0001), complement component 3
(P ¼ 0.042), rheumatoid factor (P ¼ 0.0001), anti-b2-glycoprotein
1 (IgA, P ¼ 0.0098; IgG, P ¼ 0.0000; IgM, P ¼ 0.0000), the presence
of antinuclear antibody (P ¼ 0.01) and cryoglobulins (P ¼ 0.0000),
and decreased concentration of complement component 4
(P ¼ 0.002). There was no significant difference in circulating
immune complex concentration (P ¼ 0.097).
Conclusions: A longer duration of heroin dependence was associated with increased concentrations of IgA, IgG, IgM, complement
component 3, rheumatoid factor, anti-b2-glycoprotein 1 (IgA, IgG,
IgM), presence of antinuclear antibodies and cryoglobulins, and
decreased concentrations of complement component 4, but there
was no influence on circulating immune complex values.
the duration of drug use. In this study, we assessed the association
between the duration of heroin dependence and various humoral
immunologic indicators, including IgA, IgG, IgM, complement
component 3, complement component 4, rheumatoid factor, antib2-glycoprotein 1 (IgA, IgG, IgM), antinuclear antibody, circulating
immune complexes, and cryoglobulins.
Methods: A total of 363 patients with heroin dependence were
enrolled in this cross-sectional and prospective study over a 3.5-
year period. Depending on the duration of heroin use, participants
were divided into 3 groups: up to 3 years, 4 to 7 years, and more than
7 years of heroin dependence. All patients were analyzed for the
indicators.
Results: There was a significant difference between the duration of
heroin dependence and increased concentration of IgA (P ¼ 0.0000),
IgG (P ¼ 0.0000), IgM (P ¼ 0.0001), complement component 3
(P ¼ 0.042), rheumatoid factor (P ¼ 0.0001), anti-b2-glycoprotein
1 (IgA, P ¼ 0.0098; IgG, P ¼ 0.0000; IgM, P ¼ 0.0000), the presence
of antinuclear antibody (P ¼ 0.01) and cryoglobulins (P ¼ 0.0000),
and decreased concentration of complement component 4
(P ¼ 0.002). There was no significant difference in circulating
immune complex concentration (P ¼ 0.097).
Conclusions: A longer duration of heroin dependence was associated with increased concentrations of IgA, IgG, IgM, complement
component 3, rheumatoid factor, anti-b2-glycoprotein 1 (IgA, IgG,
IgM), presence of antinuclear antibodies and cryoglobulins, and
decreased concentrations of complement component 4, but there
was no influence on circulating immune complex values.