Role and Significance of Markers of Inflammation in the Asthmatic Disease
Journal
Open Access Macedonian Journal of Medical Sciences
Date Issued
2015-12-15
Author(s)
Goseva, Zlatica
Jovanovska Janeva, Elena
Gjorcev, Angelko
Abstract
BACKGROUND: Asthma is characterized by airway inflammation which can be reversible.
AIM: Investigation the importance of eosinophils, ECP and IL-5 in asthmatics versus patients with
obstructive bronchitis and healthy subjects. We investigated the values before and after the
treatment in asthmatics.
MATERIAL AND METHODS: We studied 77 subjects divided in three groups as follows: 1) asthma
patients; 2) patients with obstructive bronchitis and 3) control group of healthy subjects. In all the
subjects there were determined: Total number of eosinophils (Eo), eosinophilic cationic protein
(ECP), Interleukin 5 (IL-5) and allergy tests.
RESULTS: The total number of eosinophils was significantly increased in the group of asthma
patients versus second and third group. We found that the presence of ECP demonstrate an
ongoing inflammation, with or without clinical symptoms of asthma patients. There was significant
difference between the values of ECP of asthma patients versus second and third group. Our
results have shown that IL-5 was significantly increased versus second group and controls (p <
0.01). We also found the decrease of the values of inflammatory markers after the treatment with
corticosteroids.
CONCLUSIONS: Eosinophils, ECP and IL-5 could be useful markers for selecting allergic patients
and could be the monitors of treatment effects
AIM: Investigation the importance of eosinophils, ECP and IL-5 in asthmatics versus patients with
obstructive bronchitis and healthy subjects. We investigated the values before and after the
treatment in asthmatics.
MATERIAL AND METHODS: We studied 77 subjects divided in three groups as follows: 1) asthma
patients; 2) patients with obstructive bronchitis and 3) control group of healthy subjects. In all the
subjects there were determined: Total number of eosinophils (Eo), eosinophilic cationic protein
(ECP), Interleukin 5 (IL-5) and allergy tests.
RESULTS: The total number of eosinophils was significantly increased in the group of asthma
patients versus second and third group. We found that the presence of ECP demonstrate an
ongoing inflammation, with or without clinical symptoms of asthma patients. There was significant
difference between the values of ECP of asthma patients versus second and third group. Our
results have shown that IL-5 was significantly increased versus second group and controls (p <
0.01). We also found the decrease of the values of inflammatory markers after the treatment with
corticosteroids.
CONCLUSIONS: Eosinophils, ECP and IL-5 could be useful markers for selecting allergic patients
and could be the monitors of treatment effects
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