POSTOPERATIVE SERUM CREATININ LEVEL IN TWO DIFERENT HYDRATION REGIMES IN LIVING DONOR KYDNEY TRANSPLANATATION
Date Issued
2017-04
Author(s)
Mojsova Mijovska, Maja
Abstract
Introduction: Early graft function is very important and can be achieved with adequate
intraopeartive perfusion characteristics of the graft and urine output. The goal of this study was
to examine the influence of targeting central venous pressure (CVP) on early graft function.
Material and methods: After approval of Ethical committee of the Medical Faculty-Skopje,
we obtained inform consent of 60 patients, ASA 2-3 undergoing renal transplantation of livingrelated person in the Clinic of Urology – Skopje. A prospective clinical study was performed in
the period of 2 years. Patients were divided into 2 groups of thirty patients : group A receiving
normal saline intraoperatively targeting for CVP to 15 mmHg until vascular clamps were off
and group B receiving normal saline 10ml/kg/h.
We recorded lactate at the end of the surgery, onset of diuresis and total urine output from
unclamping the renal vessels to the end of the surgery in both groups and postoperative serum
creatinine in 3times (3, 12, 36 hours).
Results: The onset of diuresis in seconds was insignificantly longer in group B p>0,05
(p=o,31). The average value of postoperative levels of the lactate showed that in group B the
levels of the lactate were significantly higher for Z=-5,79 and p<0,001 (p=0,000). We didn’t find
any statistical differences in postoperative serum creatinine in both groups.
Conclusion: Our study didn’t show any benefit from targeting CVP to 15 mmHg. We couldn’t
find any significant difference on onset of diuresis and urine output after the unclamping the
vessels. However, in the constant infusion group (group B) the level of the lactate was higher
CVP. In postoperative biochemical parameters we had no statistical difference between the
average values of serum cratinine.
intraopeartive perfusion characteristics of the graft and urine output. The goal of this study was
to examine the influence of targeting central venous pressure (CVP) on early graft function.
Material and methods: After approval of Ethical committee of the Medical Faculty-Skopje,
we obtained inform consent of 60 patients, ASA 2-3 undergoing renal transplantation of livingrelated person in the Clinic of Urology – Skopje. A prospective clinical study was performed in
the period of 2 years. Patients were divided into 2 groups of thirty patients : group A receiving
normal saline intraoperatively targeting for CVP to 15 mmHg until vascular clamps were off
and group B receiving normal saline 10ml/kg/h.
We recorded lactate at the end of the surgery, onset of diuresis and total urine output from
unclamping the renal vessels to the end of the surgery in both groups and postoperative serum
creatinine in 3times (3, 12, 36 hours).
Results: The onset of diuresis in seconds was insignificantly longer in group B p>0,05
(p=o,31). The average value of postoperative levels of the lactate showed that in group B the
levels of the lactate were significantly higher for Z=-5,79 and p<0,001 (p=0,000). We didn’t find
any statistical differences in postoperative serum creatinine in both groups.
Conclusion: Our study didn’t show any benefit from targeting CVP to 15 mmHg. We couldn’t
find any significant difference on onset of diuresis and urine output after the unclamping the
vessels. However, in the constant infusion group (group B) the level of the lactate was higher
CVP. In postoperative biochemical parameters we had no statistical difference between the
average values of serum cratinine.
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