MATERNAL OBESITY, АGE AND MATERNAL THYROID STATUS - AN INTRIGUING CONNECTION TO THE NEONATAL OUTCOME
Journal
Македонски медицински преглед = Macedonian Medical Review
Date Issued
2020
Author(s)
Avramovska, Maja
Karanfilski, Borislav
Abstract
Introduction. Thyroid dysfunction is the second most
common endocrine disorder affecting women of reproductive age. Higher body mass index (BMI>30 kg/m2) is linked with many endocrine abnormalities, including
thyroid dysfunction. Gestational age at birth (GAB) and
birth weight (BW) are important predictors of neonatal
mortality and morbidity. The objective of this prospective
study was to determine the adverse neonatal outcomes
of women [small for gestational age (SGA), intrauterine growth restriction (IUGR) and others] complicated
with impaired thyroid function and obesity, when
compared with those with normal function.
Methods. Dried blood spot and urine samples were
analyzed for thyroid and iodine status in 358 pregnant
women in any gestational week, without known thyroid
disorders. They gave birth at the University Clinic of
Gynecology and Obstetrics-Skopje. The blood samples
were analyzed with time-resolved fluoroimmunoassay
in Zurich, and UIC was analyzed by mass spectrometry
in Helsinki.
Results. We found a significant positive correlation
between total thyroxine (TT4) and GAB (p=0.045) and
UIE and mother age (p=0.007), but a significant negative correlation between GAB and UIE (p=0.051), GAB
and mother’s age (p=0.01), GAB and BMI (p=0.02).
There was an inverse correlation between BW and maternal age (βst=-0.0641, P=0.010) and between BW
and maternal TT4 (βst=-3.3640, P=0.0016). We found
a positive correlation between BW and maternal BMI
(βst = 21.847, P = 0.006).
Conclusion. Overweight, obese and older women are at increased risk of thyroid dysfunction during pregnancy considered as high-risk pregnancies for adverse neonatal outcomes. We can use maternal TT4, BMI and age for predicting the BW.
common endocrine disorder affecting women of reproductive age. Higher body mass index (BMI>30 kg/m2) is linked with many endocrine abnormalities, including
thyroid dysfunction. Gestational age at birth (GAB) and
birth weight (BW) are important predictors of neonatal
mortality and morbidity. The objective of this prospective
study was to determine the adverse neonatal outcomes
of women [small for gestational age (SGA), intrauterine growth restriction (IUGR) and others] complicated
with impaired thyroid function and obesity, when
compared with those with normal function.
Methods. Dried blood spot and urine samples were
analyzed for thyroid and iodine status in 358 pregnant
women in any gestational week, without known thyroid
disorders. They gave birth at the University Clinic of
Gynecology and Obstetrics-Skopje. The blood samples
were analyzed with time-resolved fluoroimmunoassay
in Zurich, and UIC was analyzed by mass spectrometry
in Helsinki.
Results. We found a significant positive correlation
between total thyroxine (TT4) and GAB (p=0.045) and
UIE and mother age (p=0.007), but a significant negative correlation between GAB and UIE (p=0.051), GAB
and mother’s age (p=0.01), GAB and BMI (p=0.02).
There was an inverse correlation between BW and maternal age (βst=-0.0641, P=0.010) and between BW
and maternal TT4 (βst=-3.3640, P=0.0016). We found
a positive correlation between BW and maternal BMI
(βst = 21.847, P = 0.006).
Conclusion. Overweight, obese and older women are at increased risk of thyroid dysfunction during pregnancy considered as high-risk pregnancies for adverse neonatal outcomes. We can use maternal TT4, BMI and age for predicting the BW.
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