Malignancy in patients with opioid use disorder: A late diagnosis in patient on maintenance treatment with Buprenorphine, with lethal effect: a case report
Journal
Merit Research Journal of Medicine and Medical Sciences
Date Issued
2016-03
Author(s)
Antonio Gligorievski
Abstract
Heroin dependents might be at a higher risk of death from cancer than the
general population. A 31-year-old male on maintenance treatment with
Buprenorphine, came to our Clinic with paralysis of his legs. He also
complained on spinal pains. He couldn’t walk and he was in forced position.
The biochemical analysis showed high values of SE, LDH, globulins, CRP,
D-dimer, Tu markers: beta HCG, CYFRA 21-1, presence of paraproteins. The
other investigations showed enlarged lymph nodes in the abdomen and
small pelvis, thrombosis of v.cava inf and right v. iliaca. The histological
finding from the biopsy of the sacrum showed a metastatic process on the
skeletal muscles. The patient was treated with buprenorphine, antibiotic
therapy, Carbamazepine, anticoagulant therapy and other symtomatic
therapy. Despite numerous investigations and treatment, bleeding and
abscesses in the cerebrum occurred. The patient immediately underwent
surgery and his recovery was well. He was discharged on his request, but
his condition was deteriorated sharply at home and he died in a short time.
There are few studies on malignant diseases found in heroin dependents. It
is a challenge to monitor and also to compare the incidence of malignancy
between heroin dependents and healthy population.
general population. A 31-year-old male on maintenance treatment with
Buprenorphine, came to our Clinic with paralysis of his legs. He also
complained on spinal pains. He couldn’t walk and he was in forced position.
The biochemical analysis showed high values of SE, LDH, globulins, CRP,
D-dimer, Tu markers: beta HCG, CYFRA 21-1, presence of paraproteins. The
other investigations showed enlarged lymph nodes in the abdomen and
small pelvis, thrombosis of v.cava inf and right v. iliaca. The histological
finding from the biopsy of the sacrum showed a metastatic process on the
skeletal muscles. The patient was treated with buprenorphine, antibiotic
therapy, Carbamazepine, anticoagulant therapy and other symtomatic
therapy. Despite numerous investigations and treatment, bleeding and
abscesses in the cerebrum occurred. The patient immediately underwent
surgery and his recovery was well. He was discharged on his request, but
his condition was deteriorated sharply at home and he died in a short time.
There are few studies on malignant diseases found in heroin dependents. It
is a challenge to monitor and also to compare the incidence of malignancy
between heroin dependents and healthy population.
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