Correlation Between Microvessel Density and Morphological Features in Skin Squamous Cell Carcinoma

Kakasheva-mazhenkovska, Lena; Basheska, Neli; Crvenkova, Simonida; Petrushevska, Gordana; Milenkova, Liljana; Janevska, Vesna; Serafimoski, Vladimir

doi:10.1515/prilozi-2017-0009

Correlation Between Microvessel Density and Morphological Features in Skin Squamous Cell Carcinoma

Journal

PRILOZI

Date Issued

2017-03-01

Author(s)

Serafimoski, Vladimir

DOI

10.1515/prilozi-2017-0009

Abstract

Abnormal angiogenesis is described in tumor growth and it facilitates its metastatic spread. Tumors with high angiogenic activity belong to the category of aggressive tumors with poor prognosis for patients. The aim of this study was to determine the blood vessels density (BVD), i.e. neovascularization at the tumor invasive front in skin squamous cell carcinoma (SCC) in order to determine its possible role in the tumor progression, and to correlate it to the blood vessels density of healthy skin and with the prognostic parameters of the TNM classification: T status, depth of tumor invasion (DI) and tumor histological grade (G), which were also correlated between each other.