Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/4739
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dc.contributor.authorPopovski, Z Ten_US
dc.contributor.authorTanaskovska, Ben_US
dc.contributor.authorMiskoska-Milevska, Een_US
dc.contributor.authorAndonov, Sen_US
dc.contributor.authorDomazetovska, Sen_US
dc.date.accessioned2019-11-04T13:44:54Z-
dc.date.available2019-11-04T13:44:54Z-
dc.date.issued2016-12-01-
dc.identifier.issn1311-0160-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/4739-
dc.description.abstractStress syndrome is usually caused by a mutation in the ryanodine receptor gene (ryr1) and it is widely studied in humans and swine populations. The protein product of this gene plays a crucial role in the regulation of calcium transport in muscle cells. A G>T mutation in the human ryr1 gene, which results in the replacement of a conserved arginine at position 614 where a leucine occurs at the same position as the previously identified Arg→Cys mutation reported in all cases of porcine stress syndrome (PSS). Porcine stress syndrome affects biochemical pathways in stress-susceptible individuals during a stress episode and some biochemical parameters that were used as markers for diagnostic purposes. Also, PSS has remarkable influence on the maternal characteristics of sows. This study dealt with different genotypes for PSS and its association with possible biochemical changes and maternal traits of sows. Seventy-three reproductive sows genotyped for PSS by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were included in this survey. Sixty of them were stress-free (NN), 11 were heterozygous carriers (Nn) and two animals were homozygous (nn) for the 1843 (C>T) mutation. Significant differences in non stress induced animals with different PSS genotypes were found in the values of creatine phoshokinase (CPK), lactate dehydrogenase (LDH), alkaline phosphatase (AP) and aspartate aminotransferase (AST). Regarding the maternal traits, our study showed that stress susceptible animals (nn) have an increased number of stillborn piglets and a reduced number of newborn piglets compared with heterozygous and normal animals.en_US
dc.language.isoenen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.relation.ispartofBalkan journal of medical genetics : BJMGen_US
dc.subjectBiochemistry; Genotypes; Maternity; Porcine stress syndrome (PSS).en_US
dc.titleAssociations of biochemical changes and maternal traits with mutation 1843 (C>T) in the RYR1 gene as a common cause for porcine stress syndromeen_US
dc.typeArticleen_US
dc.identifier.doi10.1515/bjmg-2016-0039-
dc.identifier.urlhttp://content.sciendo.com/view/journals/bjmg/19/2/article-p75.xml-
dc.identifier.urlhttp://www.degruyter.com/view/j/bjmg.2016.19.issue-2/bjmg-2016-0039/bjmg-2016-0039.pdf-
dc.identifier.volume19-
dc.identifier.issue2-
item.fulltextNo Fulltext-
item.grantfulltextnone-
Appears in Collections:Faculty of Agricultural Sciences and Food: Journal Articles
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