Pejkova, Sofija
Preferred name
Pejkova, Sofija
Official Name
Pejkova, Sofija
Main Affiliation
44 results
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Item type:Publication, Carpal tunnel syndrome caused by lipoma(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University Skopje, R.N.Macedonia, 2021-03); ; ; Georgieva GCarpal tunnel syndrome as a result of space occupying masses is very rare. Lipomas located in the carpal tunnel were found in small number of cases. In this case report, we present a case of a middle-aged woman with progressive muscle atrophy of the thenar and loss of sensation on the right hand innervated by the median nerve. Clinical examinations, electromyography and MRI were done, and a soft tissue mass, the most likely lipoma, was found in the carpal tunnel making pressure to the median nerve. Surgery was performed, decompression of the median nerve was provided, and results after two months showed complete improvement of the motor end sensory function of the hand. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Use of platelet rich plasma and split thickness skin graft in post-infection soft tissue defects, our initial experience(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University Skopje, R.N.Macedonia, 2020-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Platlet-Rich Plasma - Review of Literature(Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH, 2021-04-23); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Operative treatment of III grade open fractures of the tibial diaphysis(Macedonian Academy of Sciences and Arts, 2006); ; Saveski JOpen fractures, especially III grade open fractures of the tibial diaphysis, according to the Gustilo classification still remains a serious therapeutic problem. The aim of the study was to evaluate the clinical results after operative treatment of III grade open fractures of diaphysis of the tibia and to promote a new method of fracture fixation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Лимитирана калибрирана интрамедуларна фиксација во третманот на отворените скршеници на дијафизата на тибијата(Македонско здружение на ортопеди и травматолози = Macedonian Association of orthopedics and traumatology, 2006-08); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study(Wiley, 2022-01); ; ; Chokleska, NSARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular Biology and Genetic Mechanisms in the Progression of Malignant Skin Melanoma(Macedonian Academy of Sciences and Arts / Sciendo, 2016-11); ; ; Malignant skin melanoma is a tumor deriving from transformed skin melanocytes as a result of complex interactions between genetic and environmental factors. This melanoma has a potential to metastasize early and very often it is resistant to the existing modalities of the systemic therapy. As in any other neoplasms, certain types of melanoma may skip certain stages of progression. The progression from one stage to another is accompanied by specific biological changes. Several key changes in the melanoma tumorogenesis influence the regulation of the cell proliferation and vitality, including the RAS-RAF-ERK, PI3K-AKT, and p16INK4/CDK4/RB pathways. A key role in the dissreguarity of the RAS-RAF-ERK (MAPK) pathway in the malignant melanoma development have been demonstrated by many studies. To date, the molecular genetic alterations during melanoma development have been partially known. In the pathogenesis of the malignant melanoma, there are mutations of various genes such as NRAS, BRAF, and PTEN and mutations and deletions of CDKN2A. In the past years, great advance has been made in the insights of the molecular aspects of the melanoma pathogenesis. However, this field yet poses a challenge to discover new details about the melanoma molecular characteristics. The research results are focused towards the improvement of the melanoma patients prognosis by introducing personalized targeted therapy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Platelet-rich plasma as a promising bioscaffold for enhancing peripheral nerve regeneration: An experimental study in a rat sciatic nerve model(Journal of Biological Methods, 2025); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Timing of surgery following SARS ‐ CoV ‐ 2 infection: an international prospective cohort study(Association of Anaesthetists, 2021-03); ; Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection were compared with those without previous SARS‐CoV‐2 infection. The primary outcome measure was 30‐day postoperative mortality. Logistic regression models were used to calculate adjusted 30‐day mortality rates stratified by time from diagnosis of SARS‐CoV‐2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre‐operative SARS‐CoV‐2 diagnosis. Adjusted 30‐day mortality in patients without SARS‐CoV‐2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre‐operative SARS‐CoV‐2 diagnosis, mortality was increased in patients having surgery within 0–2 weeks, 3–4 weeks and 5–6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3–4.8), 3.9 (2.6–5.1) and 3.6 (2.0–5.2), respectively). Surgery performed ≥ 7 weeks after SARS‐CoV‐2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9–2.1)). After a ≥ 7 week delay in undertaking surgery following SARS‐CoV‐2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2–8.7) vs. 2.4% (95%CI 1.4–3.4) vs. 1.3% (95%CI 0.6–2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS‐CoV‐2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of functional and radiologic outcome after conservative treatment of distal radius fractures(Macedonian Association of Anatomists and Morphologists, 2011); ; ;