Nikoloska, Katerina
Preferred name
Nikoloska, Katerina
Official Name
Nikoloska, Katerina
Alternative Name
K. Nikoloska
Nikoloska K.
Николоска, Катерина
Катерина Николоска
К. Николоска
Николоска К.
Katerina Nikoloska
Dudeska Katerina
Katerina Dudeska
Dudeska K.
K. Dudeska
Main Affiliation
Email
katerina.nikoloska@medf.ukim.edu.mk
18 results
Now showing 1 - 10 of 18
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Item type:Publication, ROBSON CLASSIFICATION OF CESAREAN SECTION IN NORTH MACEDONIA - CURRENT TRENDS(Македонско лекарско друштво = Macedonian medical association, 2021); ; ; ; Dalipi, AdelinaAbstract Introduction. Over the last few decades, the global cesarean section rate has significantly increased and reached an unprecedented level. The World Health Organization (WHO) has advised that cesarean section (CS) rates should not rise above 15%. Several classify¬cation systems have been proposed to tackle the increased cesarean section epidemic. Most of the countries have adopted and started using the Robson (10 groups) classification as the best and the one that is the easiest internationally applicable CS classification. Aim. To present the Robson classification as a way to start better classification of cesarean section and hence to reduce the number of unnecessary cesarean section deliveries. Methods: This study was realized at the University Clinic for Gynecology and Obstetrics in Skopje, North Macedonia. It is a retrospective study where two years were compared. Results. The rate of cesarean sections for 2017 was 38.5% and for 2019 42.6%. Categorization of deliveries according to Robson criteria showed a different rate of cesarean section for each subgroup. Discussion. The implementation of the Robson classi-fication in most countries has shown a reduction in the number of cesarean deliveries and thus a reduction in overall maternal and neonatal morbidity and mortality. The analysis has shown that group 5 had the largest number of cesarean section deliveries in both years, 2017 and 2019; these were patients with previous cesarean sections. They were followed by group 1 and 2, or pri¬mi¬para with spontaneous onset and induced delivery. Conclusion. The goal of Robson clasification is to identify the target groups that contribute most in the percentage of cesarean sections and to act on these tar-get groups through appropriate education and training. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE IMPACT OF THYROID STIMULATING HORMONE (TSH), TOTAL THYROXINE (TT4) AND URINARY IODINE CONCENTRATION (UIC) ON NEONATAL OUTCOME AND PRETERM DELIVERY(Македонско лекарско друштво = Macedonian Medical Association, 2020); ; Introduction. Impaired maternal thyroid metabolism is associated with poor outcomes for the mother, the developing newborn and preterm delivery. The aim of this study was to investigate the impact of thyroid stimulating hormone (TSH), total thyroxine (TT4) and urinary iodine concentration (UIC) on neonatal outcome and preterm delivery. Methods. From the cohort of 358 healthy pregnant women (mean age 30.15±5.26 years)three subgroups were formed accordingto gestational week of pregnancy. TSH and TT4 were analyzed with time-resolved fluoroimmunoassay and UIC by mass spectrometry. Correlation of thyroid parameters with other variables was analyzed by Pierson’s correlation test. Logistic regressionwas used to predict the neonatal outcome and preterm delivery. Receiver operating characteristics curve analysis was used to calculate cut-off value of TT4 as predictors of treating preterm delivery (TPD). Results. There was a statistically significant difference in TSH (0.471±0.82 mIU/L vs. 0.544±0.337 mIU/L, P=0.016) betweenprematurely delivered and delivered atterm. TSH had a statistically significant predictive impact on the !PD in the second trimester (Exp &=-0.0532, Wald=4.6003, P=0.032). TT4 assumed a predictive impact in thethird trimester (Exp &=1.0227, Wald=6.0254, P=0.014). The cut-off point of TT4 in detecting of TPD was131.3 nmol/L, area under the curve =0.66. Conclusion. The results of this study suggest that values of maternal TT4 and TSH show possible predictive impact of preterm birthin the second and third trimester, which varies by gestational age. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LIPOLEIOMYOMA UTERI IN POSTMENOPAUSAL WOMAN(SHMSHM - AAMD, 2025-09-09); ; ; ; Micevska, MegiLipoleiomyomas are uncommon benign neoplasms of uterus and are considered to be a variant of uterine myomas. Their reported incidence varies from 0.03 to 0.2%. Lipoleiomyoma consists of variable proportion of mature lipocytes and smooth muscle cells. These tumors generally occur in asymptomatic obese perimenopausal or menopausal women. We report this case of uterine lipoleiomyoma because of its rarity. USMT (uterine smooth muscle tumors) are divided into 5 groups according to WHO tumor classification system 2020.The most commonly used detection methods is ultrasound examination. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Increased level of IL-8 in amniotic fluid in early second trimester linked with preterm pregnancies.(ID Design DOOEL Skopje, 2020-01-15); ; ; Cytokines (IL-1, IL-6, IL-8, TNF- alfa) are of crucial importance during pregnancy; they are produced by the placenta in the amniotic fluid and they are elevated in case of intrauterine inflammation. The аim of the study was to prove the ratio between the increased IL-8 in the amniotic fluid in the beginning of the second trimester (16-22 g.w.) and premature birth (< 36.6 g.w.). Material and methods: This was a prospective study that included 150 pregnant patients that had clinical indication for amniocentesis (advanced mother’s age, abnormal test of PRISCA I, suspicious anomalies of the fetus, virus infection or mother’s wish). They all gave a signed consent on being informed about the aims of the study, and following the protocol, they were analyzed and examined i.e. all patients underwent ultrasound examination, vaginal cervicometry. Five ml. of amniotic fluid during the process of amniocentesis was taken for the purpose of the study. All patients were followed until they gave birth, and the exact week of gestation was noted and compered with the IL-8 level. Results: All 150 patients were in the period of 16th-22nd gestational weeks. Twenty of the total of 150 patients had preterm delivery. A total of 139 patients conceived naturally and 9 patients underwent in vitro fertilisation (IVF) and embryo transfer (ET). In those with IVF and ET, 3 had preterm birth. 80% of patients that had preterm birth had increased IL- 8 levels. Median cervical length in those who gave birth at term was 32.1 mm and in those who gave preterm birth was 30.7mm. Conclusion: The study has confirmed the reason for examining cytokines as a method of discovering asymptomatic changes in patients who would give a premature birth. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, TRANSVERSUS ABDOMINIS RELEASE: A CASE REPORT(Association of Albanian Medical Doctors in Macedonia, 2020-08); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, FIRST AND SECOND TRIMESTER MEDICAL ABORTION - PILOT STUDY IN REPUBLIC OF NORTH MACEDONIA(Македонско лекарско друштво = Macedonian medical association, 2021); ; ; ; Introduction. Medical abortion is a procedure in which medication is used to end a pregnancy up to 22 weeks of gestation. The aim of this study was to assess the efficiency, safety and acceptance of medical abortion in the first and second trimester using a regimen of medications, mifepristone followed by misoprostol. Methods. In a prospective study, conducted at the University Clinic for Gynecology and Obstetrics in Skopje in the period from March to November 2021, women that came for medical abortion in the first and second trimester were enrolled. They were divided into two groups: Group I (5 to 12 weeks of gestation) and Group II (12 to 22 weeks of gestation). Participants in Group I were given 200 mg mifepristonе for peroral application and after 24 hours instructed for sublingual application of 800 µg misoprostol at home. Participants in Group II were hospitalized and treated with the same regimen. Additional dosage of misoprostol was given to complete abortion. Results. A total of 208 women with medical abortion up to 22 weeks of gestation (173 in the first group and 35 in the second group) were enrolled in the study. In the first group a complete uterine evacuation was achieved in 168 women (97.1%) and in 25 women (71.4%) in the second group. Acceptability of the method was high among both groups (95.14 % in Group I and 82.14 % in Group II). All doctors/clinicians who participated in this pilot study were satisfied with the method. Conclusions. Medical abortion is effective, safe and acceptable option for women in the first and second trimester. Acceptability of the method was high among both groups. All doctors/clinicians who participated in this pilot study were satisfied with the method and would offer it as an option to their patients in the future. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A RARE CASE OF UTERINE SMOOTH MUSCLE TUMOR OF UNCERTAIN MALIGNANT POTENTIAL (STUMP)(SHMSHM - AAMD, 2024-12-25); ; ; ; Shabani, AjlaLeiomyomas are uterine mesenchymal benign tumors derived from smooth muscle cells . These tumors are the most common neoplasm of the uterus. Diagnosis of STUMP is clinically difficult and definite diagnosis can be confirmed after surgery (total abdominal hysterectomy with or without salpingo-oophorectomy). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HETEROGENEITY OF ENDOMETRIUM – AN INCREASED RISK FACTOR FOR ENDOMETRIAL MALIGNANCY(Македонско лекарско друштво = Macedonian Medical Association, 2021-03); ; ; Introduction. The normal postmenopausal endometrium should appear thin, homogeneous and echogenic. Endometrial cancer causes the endometrium to thicken, appear heterogeneous, have irregular or poorly defined margins, and show increased color Doppler signals. Aim. To examine the correlation between endometrial echogenicity and the risk of endometrial malignancy in postmenopausal women. Methods. This was a prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics-Skopje, divided into two groups: control and examined. The coнtrol group included 40 postmenopausal patients, hospitalized and operated on due to urogenital pathology. The examined group consisted of 80 patients divided into two subgroups – a group with uterine bleeding and the other one without uterine bleeding. According to the ultrasound verified thickness of the endometrium, the two subgroups were divided according to endometrial thickness into: the first group with endometrial thick ness from 5-8 mm; the second from > 8-11mm and the third group above 11 mm. We made ultrasound examination by measuring the echogenicity of the endometrium in both groups of patients as well as in sub groups, which were also divided into other subgroups according to endometrial thickness. Results. The probability of endometrial malignancy was significantly increased by 4,938 in heterogenous endometrium. Conclusion. There are many examples of intratumor heterogeneity in endometrial malignancy, either at the morphologic or the molecular level. Attention should be paid so as not to miss minor subpopulations of tumor cells with diagnostic and prognostic relevance. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ROLE OF CYTOKINES AND THEIR PRESENCE IN THE AMNIOTIC LIQUID AS A SIGN OF EARLY DETECTION OF PREMATURE BIRTH IN PREGNANT WOMEN(Македонско лекарско друштво = Macedonian medical association, 2019); ; ; Introduction. Cytokines play a significant role in the pregnancy. They are very powerful and important me-diators of the cell growth as well as regulators of the immune and inflammatory reactions. Several cytokines (IL-1, IL-6, IL-8, TNF- alfa) are of crucial importance during the pregnancy since they are produced by the placentain the amniotic fluid, in case there is intraute-rine inflammation. Inpatients with premature birth, the intrauterine inflammation and infection is often present and leads to inflammatory syndrome of the human fetus. The intrauterine infection of the choriodecidual space and the amniotic fluid are the most common reasons for this obstetric complication, hence the most commonly examined etiologic factor. Aim. The study was conducted in order to prove the ratiobetween the increased level ofIL-6in the amniotic liquid at the beginning of the second trimester (16-22 g.w.) and the premature birth (< 36 g.w.). Methods. This is a case control study that has included 36 patientsso far.The pregnant women wererecruited fromthe Clinic of Gynaecology and Obstetrics. They all gave a signed consent on being informed about the aims of the study, and following the protocol, they were analyzed and examinedi. e. all patients under went ultra-sound examination, vaginal cervicometry; cervical and vaginal swabs were taken and 5 ml. amniotic fluid du-ring the process of amniocentesis. The study was performed at the Clinic ofGynaecology and Obstetrics, the Institute of Microbiology and Para-sitologyas well as the Institute ofImmunology and Hu-man Genetics. Results. The results obtained inthisstudy have confirmed the role of the cytokines i.e. they have shown an in-crease when there is inflammation in the intrauterine cavity which could lead in future to premature birth. There was an association between the risk of premature birth and positive cervical and vaginal swabs, length of cer-vix, and not a single case showed positive amnio-culture. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Biochemical Indicators as Predictive Markers by Combining Clinical Signs in Pre-eclampsia(ID Design 2012/DOOEL Skopje, 2020); ; ;