Dimitrovska, Aneta
Preferred name
Dimitrovska, Aneta
Official Name
Dimitrovska, Aneta
Main Affiliation
Email
aneta.dimitrovska@ff.ukim.edu.mk
18 results
Now showing 1 - 10 of 18
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Item type:Publication, Development and optimization of a generic HPLC method for the simultaneous determination of common ingredients in multi component cough and cold oral drug products using chemometrics(Macedonian Pharmaceutical Association, 2018); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Development of a stability-indicating method for evaluation of impurity profile of Atorvastatin film-coated tablets using cyano column based on core-shell technology(Society of Chemists and Technologists of Macedonia, 2022-06-30); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Possibilities and challenges of "green" chromatographic solutions(Macedonian Pharmaceutical Association, 2022-12-31); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chromatographic and Surfactant Based Potentiometric Determination of Aqueous Dissociation Constant of Mupirocin(Bentham Science Publishers Ltd., 2020-02-11); ; ; <jats:sec> <jats:title>Background:</jats:title> <jats:p>The available data concerning aqueous dissociation constant of mupirocin (sparingly soluble drug) are scarce. In this study, chromatographic, surfactant based potentiometric concept and spectrophotometric method were used for determination of the aqueous pKa value of mupirocin.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Different approaches were used for estimation of the aqueous pKa value from the apparent pKa values obtained at four ACN concentrations, ranging from 22% to 30%. The potentiometric determination of the pKa value of mupirocin was performed using different concentration of Tween 80 as a surfactant.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>The aqueous pKa value of mupirocin, determined for the first time by reverse-phase liquid chromatography method, was found to be 4.76. The obtained value was confirmed by potentiometric method (4.85). It was found that Tween 80 increases the pKa values. The linear relationship between the apparent pKa values and the surfactant concentrations was used as an approach for estimation of the aqueous pKa value. Both methods gave similar values for aqueous pKa which correspond with the theoretically obtained pKa value (4.88) using Pallas computer program. It was found that mupirocin gives pH-indipendent spectra, thus spectrophotometric method is not applicable for determination of pKa of this compound.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>This comprehensive approach used for the pKa determination enable us to obtained reliable results for the aqueous pKa value of mupirocin. The linear relationship between the pKa values and the nonionic surfactant concentrations could be used as a reliable and simple approach for determination of aqueous pKa value of sparingly soluble drugs.</jats:p> </jats:sec> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Headspace screening: A novel approach for fast quality assessment of the essential oil from culinary sage(Elsevier BV, 2016-07); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scientific approach and implementation of a measurement uncertainty in mass balance determination(Macedonian Pharmaceutical Association, 2022-12-31); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Optimization of ion-suppression reverse phase-separation of basic compounds using different mobile phases(Macedonian Pharmaceutical Association, 2022-12-31); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, An experimental design approach in optimization of an extraction procedure for AAS determination of Ca, Mg, Zn, Cu and Fe in multimineral dietary supplements(2018-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Implementation of quality by design principles in the development of microsponges as drug delivery carriers: Identification and optimization of critical factors using multivariate statistical analyses and design of experiments studies(Elsevier BV, 2015-07-15); ; ; Slavevska Raicki, RenataMicrosponges drug delivery system (MDDC) was prepared by double emulsion-solvent-diffusion technique using rotor-stator homogenization. Quality by design (QbD) concept was implemented for the development of MDDC with potential to be incorporated into semisolid dosage form (gel). Quality target product profile (QTPP) and critical quality attributes (CQA) were defined and identified, accordingly. Critical material attributes (CMA) and Critical process parameters (CPP) were identified using quality risk management (QRM) tool, failure mode, effects and criticality analysis (FMECA). CMA and CPP were identified based on results obtained from principal component analysis (PCA-X&Y) and partial least squares (PLS) statistical analysis along with literature data, product and process knowledge and understanding. FMECA identified amount of ethylcellulose, chitosan, acetone, dichloromethane, span 80, tween 80 and water ratio in primary/multiple emulsions as CMA and rotation speed and stirrer type used for organic solvent removal as CPP. The relationship between identified CPP and particle size as CQA was described in the design space using design of experiments - one-factor response surface method. Obtained results from statistically designed experiments enabled establishment of mathematical models and equations that were used for detailed characterization of influence of identified CPP upon MDDC particle size and particle size distribution and their subsequent optimization. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds(Springer Science and Business Media LLC, 2021-11-22)