Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/29277
Title: TIME-DEPENDENT EXPRESSION OF IL-1β mRNA - A PRELIMINARY STUDY FOR POSSIBLE WOUND AGE MARKER
Authors: Bitoljanu, Natasha 
Ivcheva, Ana 
Belakaposka Srpanova, Viktorija 
CHakar, LJupcho 
Siamkouri, Rosica
Stankov, Aleksandar 
Pavlovski, Goran 
Risteski, Sasho 
Jakjovski, Zlatko 
Keywords: IL-1β
wound age
real-time PCR
autopsy cases
human dermal injuries
Issue Date: 2023
Publisher: Macedonian Association of Anatomists and Morphologists
Journal: JMS - Journal of Morphological Sciences
Abstract: Accurate estimation of wound age is a very important task in forensic medicine field, because it can helps in reconstruction of crime scene. IL-1β is proinflamatory cytokine and plays a major role in wound healing process. The aim of the study is to develop a method for the reliable estimation of dermal injury age. In this study the expression of IL-1β mRNA was evaluated by real-time PCR at skin human wounds with different post-injuried period. We collected 27 human skin wound samples from forensic autopsy cases at our Institute. In our study were include samples from lacerations, incised wounds and stab wounds, with a known time of injury and death. Wound samples were divided into five groups: control group (n=5); first group consisted of cases with immediate death (n=7); second group consisted of cases with survival from 1 hour to 6 hours (n=5); the third group comprised cases with survival from 6 hours to 72 hours (n=3); the fourth group comprised cases with survival from 72 hours to 168 hours (n=7). In this study we detected increased expression levels of IL-1 β mRNA in the second group with survival time from 1 to 6 hours.
URI: http://hdl.handle.net/20.500.12188/29277
DOI: 10.55302/jms2361121b
Appears in Collections:Faculty of Medicine: Journal Articles

Show full item record

Page view(s)

10
checked on Feb 24, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.