TROPONIN I VISOKE OSETLJIVOSTI I DUŽINA BORAVKA U BOLNICI KOD AKUTNO OTROVANIH PACIJENATA SA RABDOMIOLIZOM
Date Issued
2023-05
Author(s)
Niko Bekarovski
Andon Chibishev
Afrodita Berat Huseini
Kiril Naumovski
Abstract
Cardiac troponins (cTn) are regulatory proteins that play a pivotal role in the interaction between actin
and myosin, controlling the contraction and relaxation of skeletal and cardiac muscle. The high-sensitivity cardiac troponin I assay is not entirely specific for myocardial injury. The aim is to determine the
role of hs–TroponinI on the hospital length of stay in patients with rhabdomyolysis acutely intoxicated
with psychotropic and chemical substances. In a clinically controlled prospective study, 140 patients
with rhabdomyolysis were divided into two groups depending on the intoxicating substance (psychotropic
or chemical). Rhabdomyolysis was defined as a creatine kinase (CK)>250 U/L according to the poisoning
severity score (PSS).
We analyze hs–TroponinI in both groups upon admission. In patients with rhabdomyolysis in the group
of psychotropic intoxications, the level of hs-TnI on admission significantly affected the length of hospitalization in 17.7% (R2 = 0.177). Increasing the value of the hs-TnI level per unit on admission increased
the length of hospital stay by an average of 0.016 days. In patients with rhabdomyolysis in the chemical
intoxication group, the hs-TnI level on admission has no influence on the hospital length of stay (R2 =
0.000). The increased hs-TnI level on the first day did not affect the hospital length of stay variability.
In patients with rhabdomyolysis acutely intoxicated with psychotropic substances, hs-Tn I can be used
to predict the length of hospital stay
and myosin, controlling the contraction and relaxation of skeletal and cardiac muscle. The high-sensitivity cardiac troponin I assay is not entirely specific for myocardial injury. The aim is to determine the
role of hs–TroponinI on the hospital length of stay in patients with rhabdomyolysis acutely intoxicated
with psychotropic and chemical substances. In a clinically controlled prospective study, 140 patients
with rhabdomyolysis were divided into two groups depending on the intoxicating substance (psychotropic
or chemical). Rhabdomyolysis was defined as a creatine kinase (CK)>250 U/L according to the poisoning
severity score (PSS).
We analyze hs–TroponinI in both groups upon admission. In patients with rhabdomyolysis in the group
of psychotropic intoxications, the level of hs-TnI on admission significantly affected the length of hospitalization in 17.7% (R2 = 0.177). Increasing the value of the hs-TnI level per unit on admission increased
the length of hospital stay by an average of 0.016 days. In patients with rhabdomyolysis in the chemical
intoxication group, the hs-TnI level on admission has no influence on the hospital length of stay (R2 =
0.000). The increased hs-TnI level on the first day did not affect the hospital length of stay variability.
In patients with rhabdomyolysis acutely intoxicated with psychotropic substances, hs-Tn I can be used
to predict the length of hospital stay
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